Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UNG, BET1 (from a repository: Sat Oct 12 09:53:22 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins10 (27.78 %)
The number (and %) of the tumor suppressors1 (2.78 %)
Total number of binary PPIs (saturation %)107 (16.98 %)
The number (and %) of affected PPIs34 (31.78 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI5.222
Assortativity coefficient-0.2957
The network average Clustering coefficient0.538
The number (and %) of a zero Clustering coefficients9 (25.00 %)
The number (and %) of a zero Betweenness Centrality16 (44.44 %)


List of the fusions

PPI for parental proteins: BET1,UNG All fusions
Proteins found in more fusions DDB1 (see 4 fusions); HSPB1 (see 1 fusions); RPA1 (see 1 fusions); DCAF1 (see 1 fusions); APP (see 5 fusions); PCNA (see 1 fusions); UBE2E2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BET1parental protein180.203369.325Use1 (PF09753, IPR019150): Membrane fusion protein Use1
2 UNGparental protein160.167478.143UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
3 ACIN1interactor100Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
4 APPprotein found in more fusions80.190239.158APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BCL2L13interactor2013.259Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
Carbpep_Y_N (PF05388, IPR008442): Carboxypeptidase Y pro-peptide
CEND1 (PF15677, IPR020162): Cell cycle exit and neuronal differentiation protein 1
6 CAPN11interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CCDC155interactor21.0000CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
8 DCAF1protein found in more fusions41.0000DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
9 DDB1protein found in more fusions80.61921.873CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
10 FAM9Binteractor3029.902Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
11 GOSR1interactor80.64374.332V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
12 HIST1H2BGoncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HIST1H3Ainteractor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 HSPB1oncoprotein60.90026.713HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15 MAGEA6interactor21.0000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
16 NAPAoncoprotein100.378328.215SNAP (PF14938): Soluble NSF attachment protein, SNAP
17 PCNAoncoprotein70.73310.936PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
18 POLBinteractor30.6671.000DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_2 (PF12826): Helix-hairpin-helix motif
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
19 RPA1suppressor80.76253.935Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
20 RPA2oncoprotein80.64368.220RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
21 RPA3interactor80.76253.935Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
22 SEZ6L2interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
23 SMUG1interactor100UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
24 STX12interactor90.69412.329PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
25 STX18interactor51.0000Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Phage_Integr_2 (PF13009, IPR024965): Putative phage integrase
26 STX4oncoprotein61.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
27 STX5interactor130.39796.665Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
28 STX7interactor90.69412.329SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
29 TCTN2interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
30 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
31 THOP1interactor100Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
32 TMEM17interactor60.8671.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
33 TMEM216interactor70.71449.998Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
34 UBE2E2protein found in more fusions40.33338.735UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 USHBP1interactor200DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
36 USO1interactor51.0000Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding

B a c k    t o    T o p ⇑