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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UNG, BET1 (from a repository: Sat Oct 12 09:53:22 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins10 (27.78 %)
The number (and %) of the tumor suppressors1 (2.78 %)
Total number of binary PPIs (saturation %)107 (16.98 %)
The number (and %) of affected PPIs34 (31.78 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI5.222
Assortativity coefficient-0.2957
The network average Clustering coefficient0.538
The number (and %) of a zero Clustering coefficients9 (25.00 %)
The number (and %) of a zero Betweenness Centrality16 (44.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BET1,UNG All fusions
Proteins found in more fusions DDB1 (see 4 fusions); HSPB1 (see 1 fusions); RPA1 (see 1 fusions); DCAF1 (see 1 fusions); APP (see 5 fusions); PCNA (see 1 fusions); UBE2E2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BET1parental protein180.203369.325Use1 (PF09753, IPR019150): Membrane fusion protein Use1
2 UNGparental protein160.167478.143UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
3 ACIN1interactor100Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
4 APPprotein found in more fusions80.190239.158APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BCL2L13interactor2013.259Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
Carbpep_Y_N (PF05388, IPR008442): Carboxypeptidase Y pro-peptide
CEND1 (PF15677, IPR020162): Cell cycle exit and neuronal differentiation protein 1
6 CAPN11interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CCDC155interactor21.0000CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
8 DCAF1protein found in more fusions41.0000DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
9 DDB1protein found in more fusions80.61921.873CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
10 FAM9Binteractor3029.902Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
11 GOSR1interactor80.64374.332V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
12 HIST1H2BGoncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HIST1H3Ainteractor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 HSPB1oncoprotein60.90026.713HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15 MAGEA6interactor21.0000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
16 NAPAoncoprotein100.378328.215SNAP (PF14938): Soluble NSF attachment protein, SNAP
17 PCNAoncoprotein70.73310.936PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
18 POLBinteractor30.6671.000DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_2 (PF12826): Helix-hairpin-helix motif
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
19 RPA1suppressor80.76253.935Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
20 RPA2oncoprotein80.64368.220RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
21 RPA3interactor80.76253.935Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
22 SEZ6L2interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
23 SMUG1interactor100UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
24 STX12interactor90.69412.329PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
25 STX18interactor51.0000Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Phage_Integr_2 (PF13009, IPR024965): Putative phage integrase
26 STX4oncoprotein61.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
27 STX5interactor130.39796.665Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
28 STX7interactor90.69412.329SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
29 TCTN2interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
30 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
31 THOP1interactor100Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
32 TMEM17interactor60.8671.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
33 TMEM216interactor70.71449.998Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
34 UBE2E2protein found in more fusions40.33338.735UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 USHBP1interactor200DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
36 USO1interactor51.0000Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding

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