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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KIAA2026, BET1 (from a repository: Thu Aug 1 09:20:10 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins5 (20.00 %)
The number (and %) of the tumor suppressors1 (4.00 %)
Total number of binary PPIs (saturation %)61 (20.33 %)
The number (and %) of affected PPIs23 (37.70 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI4.320
Assortativity coefficient-0.0992
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients11 (44.00 %)
The number (and %) of a zero Betweenness Centrality17 (68.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KIAA2026,BET1 All fusions
Proteins found in more fusions CREB1 (see 1 fusions); ATXN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KIAA2026parental protein5020.000IncA (PF04156, IPR007285): IncA protein
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
2 BET1parental protein180.203189.967Use1 (PF09753, IPR019150): Membrane fusion protein Use1
3 ACIN1interactor100Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
4 ATXN1protein found in more fusions200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5 BCL2L13interactor100Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
Carbpep_Y_N (PF05388, IPR008442): Carboxypeptidase Y pro-peptide
CEND1 (PF15677, IPR020162): Cell cycle exit and neuronal differentiation protein 1
6 CCDC155interactor21.0000CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
7 CDC42oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
8 CREB1oncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
9 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
10 GOSR1interactor70.8102.067V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
11 MAGEA6interactor21.0000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
12 MUS81suppressor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
13 NAPAoncoprotein51.0000SNAP (PF14938): Soluble NSF attachment protein, SNAP
14 STX12interactor90.6945.300PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
15 STX18interactor51.0000Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Phage_Integr_2 (PF13009, IPR024965): Putative phage integrase
16 STX4oncoprotein61.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
17 STX5interactor130.39739.967Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
18 STX7interactor90.6945.300SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
19 TCTN2interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
20 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
21 TMEM17interactor60.8671.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
22 TMEM216interactor60.9330.400Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
23 UBTD1interactor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
UBD (PF16455, IPR032752): Ubiquitin-binding domain
24 USHBP1interactor200DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
25 USO1interactor51.0000Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding

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