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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VWF, LINC01159 (from a repository: Wed Dec 5 16:43:26 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins5 (33.33 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)21 (20.00 %)
The number (and %) of affected PPIs13 (61.90 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.133
Assortativity coefficient-0.5617
The network average Clustering coefficient0.225
The number (and %) of a zero Clustering coefficients10 (66.67 %)
The number (and %) of a zero Betweenness Centrality12 (80.00 %)


List of the fusions

PPI for parental proteins: LINC01159,VWF All fusions
Proteins found in more fusions CALR (see 6 fusions); COL1A1 (see 14 fusions); RAC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 LINC01159interactor000NA
2 VWFparental protein130.038148.000Antistasin (PF02822, IPR004094): Antistasin family
C8 (PF08742, IPR014853, SM00832): C8 domain
Metallothio_5 (PF02067, IPR000966): Metallothionein family 5
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
VWA_N2 (PF16164, IPR032361): VWA N-terminal
3 ATXN7interactor100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
4 CACNA1Ainteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
5 CALRoncoprotein40.6671.000Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
6 COL1A1oncoprotein200COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
7 F8interactor21.0000Cu-oxidase (PF00394, IPR001117): Multicopper oxidase
Cu-oxidase_2 (PF07731, IPR011706): Multicopper oxidase
Cu-oxidase_3 (PF07732, IPR011707): Multicopper oxidase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
8 GP1BAinteractor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
9 HSP90B1suppressor30.6671.000CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
10 HSPA5oncoprotein31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
11 MAP3K3oncoprotein200PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
12 PDIA4interactor100Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
13 RAC1oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
14 SOCS4interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
15 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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