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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRPS31, COL5A2 (from a repository: Fri Mar 22 09:57:10 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins7 (12.73 %)
The number (and %) of the tumor suppressors3 (5.45 %)
Total number of binary PPIs (saturation %)407 (27.41 %)
The number (and %) of affected PPIs53 (13.02 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI14.364
Assortativity coefficient-0.2036
The network average Clustering coefficient0.510
The number (and %) of a zero Clustering coefficients4 (7.27 %)
The number (and %) of a zero Betweenness Centrality6 (10.91 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MRPS31,COL5A2 All fusions
Proteins found in more fusions STAT3 (see 2 fusions); EWSR1 (see 2 fusions); SMURF2 (see 1 fusions); CUL3 (see 1 fusions); UBC (see 4 fusions); TGM2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MRPS31parental protein510.263959.147MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
2 COL5A2parental protein20106.000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
3 BTRConcoprotein100.50011.213WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
4 CDK19interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
5 CPSF7interactor30.6675.639CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 CUL3protein found in more fusions250.442114.477Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 DAP3interactor280.50770.617DAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
8 EIF6interactor31.0000eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
9 ESR2suppressor80.7141.058zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
10 EWSR1oncoprotein90.357216.778RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
11 FLOT1interactor40.6670.500CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
12 GRSF1interactor140.5498.529RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
13 HNRNPA1interactor240.49884.669RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
14 LYSTinteractor21.0000Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4800 (PF16057): Domain of unknown function (DUF4800)
15 MAST3interactor21.0000DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
16 MRPL58interactor280.42677.553RF-1 (PF00472, IPR000352): RF-1 domain
17 MRPS10interactor110.5454.381Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
18 MRPS11interactor180.6679.937Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
19 MRPS14interactor120.5009.679Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
20 MRPS15interactor110.5455.618Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
21 MRPS18Binteractor190.59153.518Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
HTH_21 (PF13276, IPR025948): HTH-like domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
22 MRPS18Cinteractor110.5647.474Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
23 MRPS2interactor240.57234.304Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
24 MRPS21interactor90.5005.006Ribosomal_S21 (PF01165, IPR001911): Ribosomal protein S21
25 MRPS22interactor290.53062.447MRP-S22 (PF10245, IPR019374): Mitochondrial 28S ribosomal protein S22
26 MRPS23interactor180.69313.031MRP-S23 (PF10484, IPR023611): Mitochondrial ribosomal protein S23
27 MRPS24interactor100.5112.829MRP-S24 (PF14955, IPR026146): Mitochondrial ribosome subunit S24
28 MRPS25interactor150.6007.633L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
29 MRPS26interactor180.51619.987MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
30 MRPS27interactor190.50322.940MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
31 MRPS28interactor150.67613.926MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
32 MRPS33interactor100.5333.129MRP-S33 (PF08293, IPR013219): Mitochondrial ribosomal subunit S27
33 MRPS34interactor100.3568.998MRP-S34 (PF16053, IPR032053): Mitochondrial 28S ribosomal protein S34
34 MRPS35interactor230.54251.261MRP-S28 (PF10213, IPR019349): Mitochondrial ribosomal subunit protein
35 MRPS5interactor290.53258.350Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
36 MRPS6interactor60.5333.842Ribosomal_S6 (PF01250, IPR000529): Ribosomal protein S6
37 MRPS7interactor180.52319.890DUF454 (PF04304, IPR007401): Protein of unknown function (DUF454)
Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
38 MRPS9interactor260.59182.142Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
39 NANOGinteractor60.6002.467Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
40 NOL12interactor130.4369.514DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
41 PARK2suppressor150.6377.320IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 PTCD3interactor260.53250.827PPR (PF01535, IPR002885): PPR repeat
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
43 RPL6interactor240.48948.629Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
44 RPS8interactor210.51928.136Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
45 SARNPoncoprotein30.3338.639SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
46 SMURF2protein found in more fusions70.6671.373C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
47 SRPRBinteractor40.5001.867MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
48 STAT3suppressor200SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
49 TGM2protein found in more fusions200Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
50 TRA2Ainteractor260.406109.218DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
51 TRMT10Binteractor240.37745.351tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
52 UBCprotein found in more fusions130.56114.485ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
53 USP42interactor70.3816.119TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1
54 ZC3H3interactor160.49213.905zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
55 ZNF707interactor180.43119.646KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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