Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLIN3, TMIGD3 (from a repository: Mon Aug 26 04:56:35 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 68 The number (and %) of the onco-proteins 17 (25.00 %) The number (and %) of the tumor suppressors 8 (11.76 %) Total number of binary PPIs (saturation %) 225 (9.88 %) The number (and %) of affected PPIs 67 (29.78 %) The number of possible different fusions 11 PPI diameter 2 PPI radius inf The average degree of PPI 6.059 Assortativity coefficient -0.3233 The network average Clustering coefficient 0.535 The number (and %) of a zero Clustering coefficients 10 (14.71 %) The number (and %) of a zero Betweenness Centrality 20 (29.41 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TMIGD3,PLIN3	All fusions
Proteins found in more fusions	RHOBTB3 (see 1 fusions); EIF4A3/IPO11 (see 1 fusions); HSF1 (see 3 fusions); LGALS3 (see 2 fusions); APP (see 5 fusions); DHPS (see 2 fusions); SMAD2 (see 2 fusions); EEF1A1 (see 6 fusions); MYC (see 2 fusions); CTPS2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	TMIGD3	interactor	0	0	0	NA
2	PLIN3	parental protein	67	0.065	3553.357	Perilipin (PF03036, IPR004279): Perilipin family
3	AAMP	interactor	4	1.000	0	PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4	ADSL	interactor	6	0.467	7.667	DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331) Lyase_1 (PF00206, IPR022761): Lyase ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
5	ANKMY2	interactor	6	0.600	3.833	zf-MYND (PF01753, IPR002893): MYND finger Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
6	ANP32A	suppressor	5	1.000	0	SDA1 (PF05285, IPR007949): SDA1 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat
7	APP	protein found in more fusions	10	0.278	21.833	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8	ATIC	oncoprotein	3	0.667	1.000	AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme MGS (PF02142, IPR011607, SM00851): MGS-like domain
9	BTF3L4	interactor	3	0.667	1.000	NAC (PF01849, IPR002715): NAC domain
10	CALU	interactor	6	0.600	4.333	EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11	CBS	interactor	14	0.410	38.419	CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
12	CLNS1A	interactor	10	0.244	32.286	Voldacs (PF03517): Regulator of volume decrease after cellular swelling
13	CMTM5	suppressor	1	0	0	MARVEL (PF01284, IPR008253): Membrane-associating domain DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
14	CTPS2	protein found in more fusions	6	0.800	1.167	CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
15	DBNL	interactor	5	0.600	3.167	RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
16	DHPS	protein found in more fusions	7	0.667	3.000	DS (PF01916, IPR002773): Deoxyhypusine synthase
17	DSG2	oncoprotein	1	0	0	BAT2_N (PF07001, IPR009738): BAT2 N-terminus Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin (PF00028, IPR002126, SM00112): Cadherin domain Cadherin_3 (PF16184): Cadherin-like
18	DUT	interactor	8	0.357	18.000	dUTPase (PF00692, IPR008180): dUTPase
19	EEF1A1	suppressor	9	0.464	13.119	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
20	EIF4A3	protein found in more fusions	11	0.556	12.052	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
21	GDI2	interactor	5	0.700	3.000	GDI (PF00996, IPR018203): GDP dissociation inhibitor
22	HCCS	interactor	2	1.000	0	Cyto_heme_lyase (PF01265, IPR000511): Cytochrome c/c1 heme lyase
23	HIST1H2BG	oncoprotein	4	0.667	1.667	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
24	HSF1	protein found in more fusions	14	0.333	43.333	DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
25	IGBP1	interactor	7	0.429	9.900	TAP42 (PF04177, IPR007304): TAP42-like family
26	IGF2R	suppressor	2	1.000	0	ATG27 (PF09451, IPR018939): Autophagy-related protein 27 CIMR (PF00878, IPR000479): Cation-independent mannose-6-phosphate receptor repeat fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
27	IMPA2	interactor	3	1.000	0	Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
28	IPO11	protein found in more fusions	7	0.571	6.000	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein HEAT_2 (PF13646): HEAT repeats
29	IPO9	interactor	6	0.400	7.500	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Xpo1 (PF08389, IPR013598): Exportin 1-like protein UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central HEAT_EZ (PF13513): HEAT-like repeat
30	JPT1	interactor	1	0	0	JUPITER (PF17054): Microtubule-Associated protein Jupiter
31	LGALS1	interactor	5	0.600	2.500	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
32	LGALS3	oncoprotein	6	0.700	2.000	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
33	LRSAM1	interactor	8	0.571	6.667	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) LRR_8 (PF13855, IPR001611): Leucine rich repeat zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34	M6PR	interactor	1	0	0	Man-6-P_recep (PF02157, IPR028927): Mannose-6-phosphate receptor
35	MAP2K1	oncoprotein	4	0.667	0.667	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
36	MAX	suppressor	3	1.000	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SlyX (PF04102, IPR007236): SlyX
37	MTCH2	interactor	4	0.500	3.000	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
38	MTMR2	interactor	5	1.000	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain 3-PAP (PF12578, IPR022587): Myotubularin-associated protein NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
39	MYC	oncoprotein	11	0.222	32.500	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
40	NPLOC4	interactor	11	0.564	16.857	NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
41	P4HB	interactor	5	0.833	0.667	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
42	PARP6	interactor	5	0.600	3.000	PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
43	PDLIM5	interactor	12	0.545	19.990	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
44	PHGDH	interactor	4	0.667	1.067	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
45	PKM	oncoprotein	12	0.561	17.190	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
46	PKMYT1	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
47	PPA1	interactor	3	0.667	1.000	Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
48	PPA2	interactor	2	1.000	0	Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
49	PPP4R2	interactor	3	0.667	0.500	BT1 (PF03092, IPR004324): BT1 family PPP4R2 (PF09184, IPR015267): PPP4R2
50	RAB1A	oncoprotein	6	0.533	6.667	Ras (PF00071, IPR001806, SM00173): Ras family
51	RAB1B	oncoprotein	5	0.700	2.667	Ras (PF00071, IPR001806, SM00173): Ras family
52	RAB9A	oncoprotein	3	0.667	1.000	Ras (PF00071, IPR001806, SM00173): Ras family
53	RAD23B	suppressor	13	0.397	39.371	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
54	RHOA	suppressor	3	0.667	1.000	Ras (PF00071, IPR001806, SM00173): Ras family
55	RHOBTB3	protein found in more fusions	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ras (PF00071, IPR001806, SM00173): Ras family
56	RPRD1A	interactor	6	0.533	5.000	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
57	SMAD2	suppressor	5	0.500	3.000	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
58	SPG20	interactor	3	0.667	0.400	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein
59	SRP14	interactor	11	0.491	20.138	SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
60	SRP9	interactor	8	0.429	12.400	SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
61	TMEM43	interactor	1	0	0	TMEM43 (PF07787, IPR012430): Transmembrane protein 43 UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
62	UBA2	interactor	11	0.491	21.452	ThiF (PF00899, IPR000594): ThiF family UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
63	UBA5	interactor	5	0.833	0.667	Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat ThiF (PF00899, IPR000594): ThiF family
64	VAT1	interactor	1	0	0	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
65	VDAC1	interactor	2	1.000	0	Porin_3 (PF01459, IPR027246): Eukaryotic porin
66	VMA21	interactor	1	0	0	VMA21 (PF09446, IPR019013): VMA21-like domain
67	WDR4	interactor	5	0.600	3.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
68	ZSCAN26	interactor	1	0	0	C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain SCAN (PF02023, IPR003309, SM00431): SCAN domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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