Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLIN3, TMIGD3 (from a repository: Mon Aug 26 04:56:35 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins17 (25.00 %)
The number (and %) of the tumor suppressors8 (11.76 %)
Total number of binary PPIs (saturation %)225 (9.88 %)
The number (and %) of affected PPIs67 (29.78 %)
The number of possible different fusions11
PPI diameter2
PPI radiusinf
The average degree of PPI6.059
Assortativity coefficient-0.3233
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients10 (14.71 %)
The number (and %) of a zero Betweenness Centrality20 (29.41 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TMIGD3,PLIN3 All fusions
Proteins found in more fusions RHOBTB3 (see 1 fusions); EIF4A3/IPO11 (see 1 fusions); HSF1 (see 3 fusions); LGALS3 (see 2 fusions); APP (see 5 fusions); DHPS (see 2 fusions); SMAD2 (see 2 fusions); EEF1A1 (see 6 fusions); MYC (see 2 fusions); CTPS2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TMIGD3interactor000NA
2 PLIN3parental protein670.0653553.357Perilipin (PF03036, IPR004279): Perilipin family
3 AAMPinteractor41.0000PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 ADSLinteractor60.4677.667DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
5 ANKMY2interactor60.6003.833zf-MYND (PF01753, IPR002893): MYND finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
6 ANP32Asuppressor51.0000SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
7 APPprotein found in more fusions100.27821.833APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ATIConcoprotein30.6671.000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
9 BTF3L4interactor30.6671.000NAC (PF01849, IPR002715): NAC domain
10 CALUinteractor60.6004.333EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CBSinteractor140.41038.419CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
12 CLNS1Ainteractor100.24432.286Voldacs (PF03517): Regulator of volume decrease after cellular swelling
13 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
14 CTPS2protein found in more fusions60.8001.167CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
15 DBNLinteractor50.6003.167RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 DHPSprotein found in more fusions70.6673.000DS (PF01916, IPR002773): Deoxyhypusine synthase
17 DSG2oncoprotein100BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
18 DUTinteractor80.35718.000dUTPase (PF00692, IPR008180): dUTPase
19 EEF1A1suppressor90.46413.119GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
20 EIF4A3protein found in more fusions110.55612.052DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
21 GDI2interactor50.7003.000GDI (PF00996, IPR018203): GDP dissociation inhibitor
22 HCCSinteractor21.0000Cyto_heme_lyase (PF01265, IPR000511): Cytochrome c/c1 heme lyase
23 HIST1H2BGoncoprotein40.6671.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
24 HSF1protein found in more fusions140.33343.333DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
25 IGBP1interactor70.4299.900TAP42 (PF04177, IPR007304): TAP42-like family
26 IGF2Rsuppressor21.0000ATG27 (PF09451, IPR018939): Autophagy-related protein 27
CIMR (PF00878, IPR000479): Cation-independent mannose-6-phosphate receptor repeat
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
27 IMPA2interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
28 IPO11protein found in more fusions70.5716.000DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
29 IPO9interactor60.4007.500IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
30 JPT1interactor100JUPITER (PF17054): Microtubule-Associated protein Jupiter
31 LGALS1interactor50.6002.500Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
32 LGALS3oncoprotein60.7002.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
33 LRSAM1interactor80.5716.667Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34 M6PRinteractor100Man-6-P_recep (PF02157, IPR028927): Mannose-6-phosphate receptor
35 MAP2K1oncoprotein40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
36 MAXsuppressor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
37 MTCH2interactor40.5003.000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
38 MTMR2interactor51.0000GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
3-PAP (PF12578, IPR022587): Myotubularin-associated protein
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
39 MYConcoprotein110.22232.500HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
40 NPLOC4interactor110.56416.857NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
41 P4HBinteractor50.8330.667Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
42 PARP6interactor50.6003.000PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
43 PDLIM5interactor120.54519.990LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
44 PHGDHinteractor40.6671.0672-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
45 PKMoncoprotein120.56117.190PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
46 PKMYT1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
47 PPA1interactor30.6671.000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
48 PPA2interactor21.0000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
49 PPP4R2interactor30.6670.500BT1 (PF03092, IPR004324): BT1 family
PPP4R2 (PF09184, IPR015267): PPP4R2
50 RAB1Aoncoprotein60.5336.667Ras (PF00071, IPR001806, SM00173): Ras family
51 RAB1Boncoprotein50.7002.667Ras (PF00071, IPR001806, SM00173): Ras family
52 RAB9Aoncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
53 RAD23Bsuppressor130.39739.371K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
54 RHOAsuppressor30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
55 RHOBTB3protein found in more fusions31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
56 RPRD1Ainteractor60.5335.000CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
57 SMAD2suppressor50.5003.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
58 SPG20interactor30.6670.400MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
59 SRP14interactor110.49120.138SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
60 SRP9interactor80.42912.400SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
61 TMEM43interactor100TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
62 UBA2interactor110.49121.452ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
63 UBA5interactor50.8330.667Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
64 VAT1interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
65 VDAC1interactor21.0000Porin_3 (PF01459, IPR027246): Eukaryotic porin
66 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain
67 WDR4interactor50.6003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
68 ZSCAN26interactor100C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k    t o    T o p ⇑