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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins17 (25.00 %)
The number (and %) of the tumor suppressors8 (11.76 %)
Total number of binary PPIs (saturation %)225 (9.88 %)
The number (and %) of affected PPIs67 (29.78 %)
The number of possible different fusions11
PPI diameter2
PPI radiusinf
The average degree of PPI6.059
Assortativity coefficient-0.3233
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients10 (14.71 %)
The number (and %) of a zero Betweenness Centrality20 (29.41 %)


List of the fusions

PPI for parental proteins: TMIGD3,PLIN3 All fusions
Proteins found in more fusions RHOBTB3 (see 1 fusions); EIF4A3/IPO11 (see 1 fusions); HSF1 (see 3 fusions); LGALS3 (see 2 fusions); APP (see 5 fusions); DHPS (see 2 fusions); SMAD2 (see 2 fusions); EEF1A1 (see 6 fusions); MYC (see 2 fusions); CTPS2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TMIGD3interactor000NA
2 PLIN3parental protein670.0653553.357Perilipin (PF03036, IPR004279): Perilipin family
3 AAMPinteractor41.0000PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 ADSLinteractor60.4677.667DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
5 ANKMY2interactor60.6003.833zf-MYND (PF01753, IPR002893): MYND finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
6 ANP32Asuppressor51.0000SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
7 APPprotein found in more fusions100.27821.833APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ATIConcoprotein30.6671.000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
9 BTF3L4interactor30.6671.000NAC (PF01849, IPR002715): NAC domain
10 CALUinteractor60.6004.333EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CBSinteractor140.41038.419CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
12 CLNS1Ainteractor100.24432.286Voldacs (PF03517): Regulator of volume decrease after cellular swelling
13 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
14 CTPS2protein found in more fusions60.8001.167CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
15 DBNLinteractor50.6003.167RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 DHPSprotein found in more fusions70.6673.000DS (PF01916, IPR002773): Deoxyhypusine synthase
17 DSG2oncoprotein100BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
18 DUTinteractor80.35718.000dUTPase (PF00692, IPR008180): dUTPase
19 EEF1A1suppressor90.46413.119GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
20 EIF4A3protein found in more fusions110.55612.052DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
21 GDI2interactor50.7003.000GDI (PF00996, IPR018203): GDP dissociation inhibitor
22 HCCSinteractor21.0000Cyto_heme_lyase (PF01265, IPR000511): Cytochrome c/c1 heme lyase
23 HIST1H2BGoncoprotein40.6671.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
24 HSF1protein found in more fusions140.33343.333DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
25 IGBP1interactor70.4299.900TAP42 (PF04177, IPR007304): TAP42-like family
26 IGF2Rsuppressor21.0000ATG27 (PF09451, IPR018939): Autophagy-related protein 27
CIMR (PF00878, IPR000479): Cation-independent mannose-6-phosphate receptor repeat
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
27 IMPA2interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
28 IPO11protein found in more fusions70.5716.000DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
29 IPO9interactor60.4007.500IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
30 JPT1interactor100JUPITER (PF17054): Microtubule-Associated protein Jupiter
31 LGALS1interactor50.6002.500Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
32 LGALS3oncoprotein60.7002.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
33 LRSAM1interactor80.5716.667Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34 M6PRinteractor100Man-6-P_recep (PF02157, IPR028927): Mannose-6-phosphate receptor
35 MAP2K1oncoprotein40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
36 MAXsuppressor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
37 MTCH2interactor40.5003.000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
38 MTMR2interactor51.0000GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
3-PAP (PF12578, IPR022587): Myotubularin-associated protein
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
39 MYConcoprotein110.22232.500HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
40 NPLOC4interactor110.56416.857NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
41 P4HBinteractor50.8330.667Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
42 PARP6interactor50.6003.000PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
43 PDLIM5interactor120.54519.990LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
44 PHGDHinteractor40.6671.0672-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
45 PKMoncoprotein120.56117.190PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
46 PKMYT1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
47 PPA1interactor30.6671.000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
48 PPA2interactor21.0000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
49 PPP4R2interactor30.6670.500BT1 (PF03092, IPR004324): BT1 family
PPP4R2 (PF09184, IPR015267): PPP4R2
50 RAB1Aoncoprotein60.5336.667Ras (PF00071, IPR001806, SM00173): Ras family
51 RAB1Boncoprotein50.7002.667Ras (PF00071, IPR001806, SM00173): Ras family
52 RAB9Aoncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
53 RAD23Bsuppressor130.39739.371K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
54 RHOAsuppressor30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
55 RHOBTB3protein found in more fusions31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
56 RPRD1Ainteractor60.5335.000CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
57 SMAD2suppressor50.5003.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
58 SPG20interactor30.6670.400MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
59 SRP14interactor110.49120.138SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
60 SRP9interactor80.42912.400SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
61 TMEM43interactor100TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
62 UBA2interactor110.49121.452ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
63 UBA5interactor50.8330.667Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
64 VAT1interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
65 VDAC1interactor21.0000Porin_3 (PF01459, IPR027246): Eukaryotic porin
66 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain
67 WDR4interactor50.6003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
68 ZSCAN26interactor100C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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