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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins15 (20.55 %)
The number (and %) of the tumor suppressors6 (8.22 %)
Total number of binary PPIs (saturation %)158 (6.01 %)
The number (and %) of affected PPIs72 (45.57 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI3.616
Assortativity coefficient-0.4146
The network average Clustering coefficient0.462
The number (and %) of a zero Clustering coefficients25 (34.25 %)
The number (and %) of a zero Betweenness Centrality43 (58.90 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SORBS3,ADK All fusions
Proteins found in more fusions NQO1 (see 2 fusions); RBMX (see 3 fusions); DDX17 (see 3 fusions); PAK2 (see 2 fusions); BAG3 (see 4 fusions); HNRNPUL1 (see 1 fusions); MAPK1 (see 1 fusions); CBLB (see 4 fusions); CBL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SORBS3parental protein560.0254274.499Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
2 ADKparental protein160.150808.390PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
3 ADAMTSL4interactor30.6671.000ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4 AKT1oncoprotein40.333308.919PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ALBinteractor20373.825Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
6 ANAPC15interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
7 ARNT2interactor40.6672.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
8 ASS1suppressor60.5005.000Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
9 ATP6V1Hinteractor21.0000V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
10 BAG3oncoprotein70.267319.474BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
11 CAPGsuppressor31.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
12 CBLsuppressor50.5005.444Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
13 CBLBoncoprotein40.6673.567Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 CCDC22interactor100DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
15 CPNE2interactor30.6674.570C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
16 CPSF7interactor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 DAZAP1interactor80.42987.966RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
18 DDX17protein found in more fusions41.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
19 DIP2Ainteractor21.0000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
20 DLG5interactor100Takusan (PF04822, IPR006907): Takusan
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
dbPDZ_assoc (PF16610): Unstructured region between two PDZ domains on Dlg5
21 DMRTB1interactor30.6671.000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
22 DVL2interactor40.6674.570DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
23 EFSinteractor100DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
24 EIF3Hinteractor100Androgen_recep (PF02166, IPR001103): Androgen receptor
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
NHS (PF15273, IPR024845): NHS-like
25 FASLGinteractor21.0000PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
26 FICDinteractor100Fic (PF02661, IPR003812): Fic/DOC family
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
27 FLOT1interactor30.333150.715CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
28 HNRNPKoncoprotein90.214625.300ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
29 HNRNPUL1protein found in more fusions90.28634.070Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
30 KATNA1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
31 KIAA0408interactor100IncA (PF04156, IPR007285): IncA protein
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
32 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
33 KRASoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
34 KYNUinteractor30.66710.550Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
35 LDHAinteractor50.333235.419Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
36 MAPK1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
37 NCKIPSDoncoprotein30.6671.000DUF2013 (PF09431, IPR018556): Protein of unknown function (DUF2013)
Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
38 NNMToncoprotein100NNMT_PNMT_TEMT (PF01234, IPR000940): NNMT/PNMT/TEMT family
39 NOTCH3suppressor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
40 NPLOC4interactor30254.589NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
41 NQO1oncoprotein40.333224.741Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
42 PAK1oncoprotein40.6674.918PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
43 PAK2protein found in more fusions31.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
44 PAK5interactor200PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
45 PCBP1oncoprotein60.467356.259Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
46 PIRinteractor50.70018.860Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
47 PITPNBinteractor31.0000IP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
48 PTGR1interactor21.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
49 RBM12interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
50 RBMXsuppressor50.6679.797RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
51 SAFB2suppressor31.0000LicD (PF04991, IPR007074): LicD family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
52 SAXO1interactor100STOP (PF05217, IPR024963): STOP protein
DUF4572 (PF15139, IPR027905): Domain of unknown function (DUF4572)
53 SH2D4Ainteractor31.0000Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2039 (PF10217, IPR019351): Uncharacterized conserved protein (DUF2039)
54 SOCS7interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
SOCS_box (PF07525, IPR001496): SOCS box
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
55 SOD1interactor80.381319.492Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
56 SRCIN1interactor21.0000AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
57 SRD5A3interactor100Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
58 SYNCRIPinteractor40.6673.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
59 SYPinteractor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
60 TBC1D22Binteractor31.0000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
61 TRIM23interactor60.7002.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
62 TRIM27oncoprotein80.42911.000IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
63 TRIM41interactor200BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
64 TXNDC17interactor100DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
65 UBE2Tinteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
66 VARS2interactor100Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
FimP (PF09766, IPR019163): Fms-interacting protein
67 VPS37Binteractor100Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
68 VPS37Cinteractor21.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
69 WASLinteractor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
70 ZBED1interactor200Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)
71 ZBTB25interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
72 ZBTB7Binteractor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAGA (PF09237, IPR015318): GAGA factor
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
73 ZC4H2interactor100zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein

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