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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FSHR, SERF2 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins9 (29.03 %)
The number (and %) of the tumor suppressors1 (3.23 %)
Total number of binary PPIs (saturation %)57 (12.26 %)
The number (and %) of affected PPIs29 (50.88 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI2.645
Assortativity coefficient-0.5102
The network average Clustering coefficient0.396
The number (and %) of a zero Clustering coefficients14 (45.16 %)
The number (and %) of a zero Betweenness Centrality22 (70.97 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FSHR,SERF2 All fusions
Proteins found in more fusions ZBTB16 (see 3 fusions); FOXO1 (see 1 fusions); CHD3 (see 1 fusions); QKI (see 3 fusions); RBPMS (see 2 fusions); GC (see 1 fusions); PSME3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FSHRparental protein140.044557.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
2 SERF2parental protein150.057583.0004F5 (PF04419, IPR007513): 4F5 protein family
3 AKT2oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 APPL1interactor40.6671.000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
5 APPL2interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
6 BOLLinteractor21.0000NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 CBX5suppressor31.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
8 CHD3oncoprotein200CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
9 DAB1interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
10 FOXO1oncoprotein31.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
11 GCprotein found in more fusions200VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
12 GRK2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
13 GRK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
14 GRK6interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
15 KRTAP10-3interactor200Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
16 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
17 NELFCDinteractor100TH1 (PF04858, IPR006942): TH1 protein
18 PSMA3interactor40.667210.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
19 PSME3protein found in more fusions40.667210.000PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
20 QKIprotein found in more fusions40.6671.000KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
21 RBPMSprotein found in more fusions50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
22 RHOXF2interactor40.6671.000DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
23 RNR2interactor100NA
24 S100A10oncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25 SP4interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Macoilin (PF09726, IPR019130): Transmembrane protein
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
26 THAP1interactor31.0000THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
27 TOP1interactor100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
28 TUG1interactor100NA
29 UPF2interactor200DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
30 YWHAQinteractor40.333448.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
31 ZBTB16oncoprotein31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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