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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC25A13, SCARB1 (from a repository: Wed Jul 31 06:28:34 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins16 (27.59 %)
The number (and %) of the tumor suppressors5 (8.62 %)
Total number of binary PPIs (saturation %)175 (10.59 %)
The number (and %) of affected PPIs57 (32.57 %)
The number of possible different fusions14
PPI diameter4
PPI radius2
The average degree of PPI5.276
Assortativity coefficient-0.2759
The network average Clustering coefficient0.402
The number (and %) of a zero Clustering coefficients17 (29.31 %)
The number (and %) of a zero Betweenness Centrality23 (39.66 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SCARB1,SLC25A13 All fusions
Proteins found in more fusions HLA-C (see 1 fusions); NF2 (see 1 fusions); ILK (see 2 fusions); IKBKB (see 2 fusions); CUL1 (see 3 fusions); UBC (see 7 fusions); GRB2 (see 1 fusions); IMMT (see 4 fusions); PARK2 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); MYC (see 2 fusions); SKI (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SCARB1parental protein180.052892.427CD36 (PF01130, IPR002159): CD36 family
2 SLC25A13parental protein390.0811691.492Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
3 AATKinteractor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
4 ADRB2interactor80.33379.1687tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 AGO4interactor100ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
6 ALBinteractor60.333121.433Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
7 APOA1interactor40.6679.733ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
8 APOA2interactor30.6679.733ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
9 ARAFoncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
10 ASB8interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
11 ATF2oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
12 ATP1B3interactor30.6677.006Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
13 BABAM1interactor41.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
14 BREoncoprotein41.0000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
15 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
16 CAND1interactor90.42992.909Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
17 CCDC8interactor100.36141.008Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
18 CLN3interactor50.5008.098CLN3 (PF02487, IPR003492): CLN3 protein
19 CLN5interactor40.33346.591CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
20 CRKoncoprotein41.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
21 CUL1suppressor130.212210.531Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 EGFRoncoprotein110.37878.787Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23 ELAVL1oncoprotein120.291107.321RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 FBXO6interactor120.212430.642FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
25 GRB2oncoprotein120.41853.701SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
26 HLA-Cprotein found in more fusions70.33347.502Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
27 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
28 HLA-DRAinteractor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
29 IKBKBprotein found in more fusions40.6672.336FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
30 ILKsuppressor40.6672.336Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
31 IMMTprotein found in more fusions140.231106.794Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
32 IRAK1interactor80.42910.821Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
33 KRTAP10-9interactor31.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
34 KRTAP5-9interactor21.0000Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
35 LIMK2interactor21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
36 MCM2oncoprotein70.7336.368AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
37 MRPL46interactor21.0000NUDIX (PF00293, IPR000086): NUDIX domain
MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46
38 MRPL58interactor40.5002.682RF-1 (PF00472, IPR000352): RF-1 domain
39 MYConcoprotein90.35737.796HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
40 NAAAinteractor30.6677.433CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
41 NEIL3interactor100Fapy_DNA_glyco (PF01149, IPR012319, SM00898): Formamidopyrimidine-DNA glycosylase N-terminal domain
H2TH (PF06831, IPR015886): Formamidopyrimidine-DNA glycosylase H2TH domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-GRF (PF06839, IPR010666): GRF zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
42 NF2suppressor200ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
43 NTRK1oncoprotein120.45536.067I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
44 OTUB1interactor40.8330.333Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
45 PARK2suppressor70.46711.290IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 PDZK1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
47 PON2interactor50.40044.930Arylesterase (PF01731, IPR002640): Arylesterase
48 PPT1interactor30.6671.448Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
49 PTPRKsuppressor3016.586fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
50 SIK2interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
51 SIRT7interactor30.6670.733DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
52 SKIoncoprotein200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
53 SLX1Binteractor202.336GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
54 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
55 TMEM216interactor2010.117Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
56 UBCprotein found in more fusions160.314125.509ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57 USP50interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
58 XRCC3oncoprotein100Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain

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