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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNAL4, MED10 (from a repository: Sun Sep 1 04:20:55 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins12 (18.75 %)
The number (and %) of the tumor suppressors6 (9.38 %)
Total number of binary PPIs (saturation %)785 (38.94 %)
The number (and %) of affected PPIs62 (7.90 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI23.719
Assortativity coefficient0.0497
The network average Clustering coefficient0.678
The number (and %) of a zero Clustering coefficients8 (12.50 %)
The number (and %) of a zero Betweenness Centrality11 (17.19 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MED10,DNAL4 All fusions
Proteins found in more fusions MED21 (see 1 fusions); NAP1L1 (see 4 fusions); HNF4A (see 1 fusions); POLR2E (see 1 fusions); MED1/MED13L (see 1 fusions); CAMK2D (see 1 fusions); POLR2A (see 2 fusions); QKI (see 3 fusions); EPAS1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MED10parental protein530.504405.853Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
2 DNAL4parental protein90.028826.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
3 CAMK2Doncoprotein200CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
4 CCNCsuppressor310.84912.991Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
5 CDK19interactor290.9063.966Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CDK8interactor370.77925.271Pkinase (PF00069, IPR000719): Protein kinase domain
7 DYNLL2interactor200Dynein_light (PF01221, IPR001372): Dynein light chain type 1
8 EPAS1suppressor210.9421.023Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
9 ESR1suppressor330.54264.761Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
10 ESR2suppressor190.830396.316zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
11 FBXW7suppressor290.82512.691Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
12 FHL5interactor200LIM (PF00412, IPR001781, SM00132): LIM domain
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
13 GNA14interactor100G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
14 GPBP1interactor100ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
Vasculin (PF15337, IPR028128): Vascular protein family Vasculin-like 1
15 HNF4Asuppressor101.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
16 KRTAP10-3interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
17 MED1protein found in more fusions440.65876.140Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
18 MED11interactor280.8944.471Med11 (PF10280, IPR019404): Mediator complex protein
19 MED12oncoprotein380.74734.102Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
20 MED13oncoprotein310.8349.385Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
21 MED13Lprotein found in more fusions180.9740.289Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
22 MED14interactor350.76837.948Med14 (PF08638, IPR013947): Mediator complex subunit MED14
23 MED15interactor330.78224.561Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
24 MED16interactor370.75144.220WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
25 MED17oncoprotein390.71853.303Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
26 MED18interactor310.88210.933Med18 (PF09637, IPR019095): Med18 protein
27 MED19interactor450.60994.786Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
28 MED20interactor330.82417.775Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
29 MED21protein found in more fusions320.81322.479Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
30 MED22interactor250.8903.719Med22 (PF06179, IPR009332): Surfeit locus protein 5 subunit 22 of Mediator complex
31 MED23interactor390.71143.028Med23 (PF11573, IPR021629): Mediator complex subunit 23
32 MED24interactor370.76033.025Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
33 MED25interactor250.8306.880Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1
Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing
Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
34 MED26interactor450.590107.239Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
35 MED27interactor340.79516.195Med27 (PF11571, IPR021627): Mediator complex subunit 27
36 MED28interactor430.64371.550cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
37 MED29interactor470.592110.391Med29 (PF11568, IPR021018): Mediator complex subunit 29
38 MED30interactor310.85113.901Med30 (PF11315, IPR021019): Mediator complex subunit 30
39 MED31interactor190.77228.476Med31 (PF05669, IPR008831): SOH1
40 MED4interactor400.70654.637Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
41 MED6interactor330.84720.136Med6 (PF04934, IPR007018): MED6 mediator sub complex component
Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
42 MED7interactor350.78826.206Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
43 MED8interactor310.8737.008Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
44 MED9interactor400.67453.384Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
45 MOB4interactor21.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
46 NAP1L1protein found in more fusions200NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
47 NOTCH2NLinteractor40.167972.200EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
48 POLR2Aprotein found in more fusions280.63531.794RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
49 POLR2Binteractor190.8304.874RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4
RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
50 POLR2Cinteractor220.76210.388RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
51 POLR2Dinteractor160.9081.409RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
52 POLR2Eprotein found in more fusions210.8006.895RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
53 POLR2Finteractor190.7549.055RNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
54 POLR2Ginteractor310.600676.776SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
55 POLR2Hinteractor170.9171.311RNA_pol_Rpb8 (PF03870, IPR005570, SM00658): RNA polymerase Rpb8
56 POLR2Iinteractor150.9241.014RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
CpXC (PF14353, IPR025682): CpXC protein
57 POLR2Jinteractor160.9001.560RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
58 POLR2Kinteractor150.8463.752DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
59 POLR2Linteractor140.9340.625RNA_pol_N (PF01194, IPR000268): RNA polymerases N / 8 kDa subunit
60 QKIprotein found in more fusions180.8602.351KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
61 SCTRinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
62 TCL1Boncoprotein150.9430.493TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
63 TRIM54interactor200DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
64 TRIP4interactor170.8016.464ASCH (PF04266, IPR007374, SM01022): ASCH domain
UxaC (PF02614, IPR003766): Glucuronate isomerase
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type

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