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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKY, ARL4A (from a repository: Sun Dec 8 02:16:43 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins6 (37.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)28 (23.33 %)
The number (and %) of affected PPIs14 (50.00 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI2.625
Assortativity coefficient-0.1249
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients7 (43.75 %)
The number (and %) of a zero Betweenness Centrality12 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARL4A,PRKY All fusions
Proteins found in more fusions HSP90AA1 (see 6 fusions); CCDC102B (see 1 fusions); GAPDH (see 5 fusions); BAG2 (see 1 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARL4Aparental protein6030.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
2 PRKYparental protein80.25037.000NA
3 BAG2protein found in more fusions31.0000IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
4 CCDC102Bprotein found in more fusions200Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
5 CCDC57interactor200CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Fez1 (PF06818): Fez1
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
SlyX (PF04102, IPR007236): SlyX
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3983 (PF13137, IPR025041): Protein of unknown function (DUF3983)
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
6 CCT3interactor31.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT6Ainteractor31.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 GAPDHoncoprotein31.0000Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
9 GOLGA2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
10 HSP90AA1oncoprotein50.5003.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
11 KPNA2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
12 KRASoncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
13 MAPK14oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
14 MAPKAPK3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
15 SPATC1Linteractor100Speriolin_N (PF15058, IPR029385): Speriolin N terminus
Speriolin_C (PF15059, IPR029384): Speriolin C-terminus
16 TCP1interactor40.6672.000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family

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