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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HIVEP1, CDH13 (from a repository: Fri Sep 14 21:12:13 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins19 (31.67 %)
The number (and %) of the tumor suppressors9 (15.00 %)
Total number of binary PPIs (saturation %)147 (8.31 %)
The number (and %) of affected PPIs58 (39.46 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI3.933
Assortativity coefficient-0.3301
The network average Clustering coefficient0.344
The number (and %) of a zero Clustering coefficients24 (40.00 %)
The number (and %) of a zero Betweenness Centrality27 (45.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDH13,HIVEP1 All fusions
Proteins found in more fusions PRKAR1A (see 2 fusions); STAT3 (see 2 fusions); ATXN1 (see 3 fusions); SRPK2 (see 1 fusions); MAGED1 (see 1 fusions); UBC (see 1 fusions); APH1A (see 2 fusions); CCND1 (see 1 fusions); IMMT (see 4 fusions); MAPK14 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDH13parental protein120.030260.880Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cu-binding_MopE (PF11617, IPR021655): Putative metal-binding motif
2 HIVEP1parental protein460.0342671.955PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 ALDOBoncoprotein100Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4 APH1Aoncoprotein31.0000Aph-1 (PF06105, IPR009294): Aph-1 protein
5 APTXinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
6 ASGR1interactor100Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
7 ATXN1protein found in more fusions50.5004.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 ATXN1Linteractor31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
9 AURKAoncoprotein90.107109.437Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
10 BHLHE40interactor70.46711.593Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
11 BNIP3oncoprotein200BNIP3 (PF06553, IPR010548): BNIP3
12 BRCA1suppressor120.109381.655BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
13 BTRConcoprotein120.200130.669WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 CACNA1Ainteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
15 CASP8suppressor4024.249DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
16 CCND1oncoprotein5036.896Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
17 CDKN2AIPinteractor21.0000XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
18 CHEK2suppressor4019.267FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
19 CHST15interactor100Sulfotransfer_3 (PF13469): Sulfotransferase family
20 CLK1interactor40.6672.320PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
21 DGUOKinteractor200dNK (PF01712, IPR002624): Deoxynucleoside kinase
22 DNAAF2interactor2012.124Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
23 DNAJA1interactor40.6674.186DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
24 FBXW11interactor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
25 GAAinteractor100Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
26 GSDMBinteractor21.0000Gasdermin (PF04598, IPR007677): Gasdermin family
27 HAX1interactor4038.717Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
28 HMMRinteractor30.6676.502APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
29 HPDinteractor21.0000Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
30 HSPA1Ainteractor40.33325.707HSP70 (PF00012, IPR013126): Hsp70 protein
31 IMMTprotein found in more fusions31.0000Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
32 IRF5suppressor200IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
33 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
34 MAGED1protein found in more fusions41.0000MAGE (PF01454, IPR002190): MAGE family
35 MAPK14oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
36 MAPK6oncoprotein50.16730.844Pkinase (PF00069, IPR000719): Protein kinase domain
37 MAPK8oncoprotein50.33343.002DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
38 MTMR3oncoprotein2014.196FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
39 NHLH1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
40 NINJ1suppressor100Ninjurin (PF04923, IPR007007): Ninjurin
41 NUCB1interactor100DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
42 NUFIP1interactor206.502NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
43 PRKAR1Asuppressor50.50043.372RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
44 PTPN1suppressor30.33322.078Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
45 RAB1Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
46 RAB5Aoncoprotein60.200126.184Ras (PF00071, IPR001806, SM00173): Ras family
47 RAD51interactor306.502Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
48 RIDAinteractor40.6671.000Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
49 RNASEH2Binteractor100RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
50 SDCBPinteractor30.6671.119PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
51 SERTAD1interactor30.6671.786CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
52 SMAD3oncoprotein60.40014.765MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
53 SNX4interactor100PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
54 SOCS3suppressor2035.905SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
55 SOD1interactor31.0000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
56 SRPK2oncoprotein50.16764.265DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
57 STAT3suppressor70.26783.154SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
58 STAT5Boncoprotein60.30078.604SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
59 TMEM176Ainteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
60 UBCprotein found in more fusions100.222124.564ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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