Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HIVEP1, CDH13 (from a repository: Fri Sep 14 21:12:13 2018)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins19 (31.67 %)
The number (and %) of the tumor suppressors9 (15.00 %)
Total number of binary PPIs (saturation %)147 (8.31 %)
The number (and %) of affected PPIs58 (39.46 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI3.933
Assortativity coefficient-0.3301
The network average Clustering coefficient0.344
The number (and %) of a zero Clustering coefficients24 (40.00 %)
The number (and %) of a zero Betweenness Centrality27 (45.00 %)


List of the fusions

PPI for parental proteins: CDH13,HIVEP1 All fusions
Proteins found in more fusions PRKAR1A (see 2 fusions); STAT3 (see 2 fusions); ATXN1 (see 3 fusions); SRPK2 (see 1 fusions); MAGED1 (see 1 fusions); UBC (see 1 fusions); APH1A (see 2 fusions); CCND1 (see 1 fusions); IMMT (see 4 fusions); MAPK14 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CDH13parental protein120.030260.880Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cu-binding_MopE (PF11617, IPR021655): Putative metal-binding motif
2 HIVEP1parental protein460.0342671.955PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 ALDOBoncoprotein100Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4 APH1Aoncoprotein31.0000Aph-1 (PF06105, IPR009294): Aph-1 protein
5 APTXinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
6 ASGR1interactor100Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
7 ATXN1protein found in more fusions50.5004.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 ATXN1Linteractor31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
9 AURKAoncoprotein90.107109.437Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
10 BHLHE40interactor70.46711.593Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
11 BNIP3oncoprotein200BNIP3 (PF06553, IPR010548): BNIP3
12 BRCA1suppressor120.109381.655BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
13 BTRConcoprotein120.200130.669WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 CACNA1Ainteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
15 CASP8suppressor4024.249DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
16 CCND1oncoprotein5036.896Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
17 CDKN2AIPinteractor21.0000XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
18 CHEK2suppressor4019.267FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
19 CHST15interactor100Sulfotransfer_3 (PF13469): Sulfotransferase family
20 CLK1interactor40.6672.320PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
21 DGUOKinteractor200dNK (PF01712, IPR002624): Deoxynucleoside kinase
22 DNAAF2interactor2012.124Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
23 DNAJA1interactor40.6674.186DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
24 FBXW11interactor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
25 GAAinteractor100Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
26 GSDMBinteractor21.0000Gasdermin (PF04598, IPR007677): Gasdermin family
27 HAX1interactor4038.717Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
28 HMMRinteractor30.6676.502APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
29 HPDinteractor21.0000Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
30 HSPA1Ainteractor40.33325.707HSP70 (PF00012, IPR013126): Hsp70 protein
31 IMMTprotein found in more fusions31.0000Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
32 IRF5suppressor200IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
33 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
34 MAGED1protein found in more fusions41.0000MAGE (PF01454, IPR002190): MAGE family
35 MAPK14oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
36 MAPK6oncoprotein50.16730.844Pkinase (PF00069, IPR000719): Protein kinase domain
37 MAPK8oncoprotein50.33343.002DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
38 MTMR3oncoprotein2014.196FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
39 NHLH1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
40 NINJ1suppressor100Ninjurin (PF04923, IPR007007): Ninjurin
41 NUCB1interactor100DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
42 NUFIP1interactor206.502NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
43 PRKAR1Asuppressor50.50043.372RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
44 PTPN1suppressor30.33322.078Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
45 RAB1Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
46 RAB5Aoncoprotein60.200126.184Ras (PF00071, IPR001806, SM00173): Ras family
47 RAD51interactor306.502Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
48 RIDAinteractor40.6671.000Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
49 RNASEH2Binteractor100RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
50 SDCBPinteractor30.6671.119PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
51 SERTAD1interactor30.6671.786CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
52 SMAD3oncoprotein60.40014.765MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
53 SNX4interactor100PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
54 SOCS3suppressor2035.905SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
55 SOD1interactor31.0000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
56 SRPK2oncoprotein50.16764.265DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
57 STAT3suppressor70.26783.154SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
58 STAT5Boncoprotein60.30078.604SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
59 TMEM176Ainteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
60 UBCprotein found in more fusions100.222124.564ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

B a c k    t o    T o p ⇑