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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LINC00854, CD8A (from a repository: Sat Jul 13 00:28:27 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins6 (40.00 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)27 (25.71 %)
The number (and %) of affected PPIs14 (51.85 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI2.400
Assortativity coefficient-0.4458
The network average Clustering coefficient0.382
The number (and %) of a zero Clustering coefficients8 (53.33 %)
The number (and %) of a zero Betweenness Centrality13 (86.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CD8A,LINC00854 All fusions
Proteins found in more fusions COPA (see 1 fusions); HLA-B (see 4 fusions); HLA-B/HLA-C (see 4 fusions); HLA-C (see 1 fusions); LNX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CD8Aparental protein140.064144.000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
2 LINC00854interactor000PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
3 CACYBPinteractor200CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
4 CD3Dinteractor100DAP10 (PF07213, IPR009861): DAP10 membrane protein
ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
5 CD59interactor100UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
FAM163 (PF15069, IPR029379): FAM163 family
6 CD8Binteractor100Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
7 CDK1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
8 COPAprotein found in more fusions200Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 HLA-Aoncoprotein31.0000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
10 HLA-Boncoprotein41.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
11 HLA-Cprotein found in more fusions50.6672.000Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
12 HLA-Ginteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
SNO (PF01174, IPR002161): SNO glutamine amidotransferase family
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
13 LNX1protein found in more fusions31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
14 LNX2interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
15 PTPRCsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PTP_N (PF12453, IPR024739): Protein tyrosine phosphatase N terminal
CD45 (PF12567, IPR016335): Leukocyte receptor CD45
SCIMP (PF15050, IPR028181): SCIMP protein

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