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Fusion ID: Protein names:	100505876 501
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Visualization interactions

Cytoscape Web for: parental proteins ALDH7A1, CEBPZOS (from a repository: Thu Nov 22 20:36:58 2018)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	39
The number (and %) of the onco-proteins	8 (20.51 %)
The number (and %) of the tumor suppressors	2 (5.13 %)
Total number of binary PPIs (saturation %)	136 (18.35 %)
The number (and %) of affected PPIs	37 (27.21 %)
The number of possible different fusions	6
PPI diameter	2
PPI radius	inf
The average degree of PPI	6.359
Assortativity coefficient	-0.3549
The network average Clustering coefficient	0.496
The number (and %) of a zero Clustering coefficients	10 (25.64 %)
The number (and %) of a zero Betweenness Centrality	14 (35.90 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CEBPZOS,ALDH7A1	All fusions
Proteins found in more fusions	EPS8 (see 1 fusions); APP (see 4 fusions); YWHAG (see 1 fusions); YWHAH (see 2 fusions); G6PD (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CEBPZOS	interactor	0	0	0	Ndr (PF03096, IPR004142): Ndr family
2	ALDH7A1	parental protein	37	0.131	967.419	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3	ABAT	interactor	2	1.000	0	Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4	APP	protein found in more fusions	8	0.381	10.019	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	ASNS	oncoprotein	10	0.600	11.200	Asn_synthase (PF00733, IPR001962): Asparagine synthase GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6	CAPN2	interactor	5	1.000	0	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7	CAPNS1	interactor	12	0.591	13.352	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8	CAT	suppressor	7	0.600	4.733	Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
9	CPT2	interactor	1	0	0	Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
10	DDA1	interactor	3	0.667	0.333	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
11	EIF5	interactor	12	0.455	25.667	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
12	EPS8	oncoprotein	2	0	0	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13	ERP44	interactor	4	0.667	0.800	Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
14	FAHD2A	interactor	3	1.000	0	FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
15	FERMT2	interactor	8	0.679	5.333	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
16	G6PD	protein found in more fusions	11	0.556	13.119	G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
17	GLA	interactor	4	0.833	0.500	Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
18	GOT1	interactor	1	0	0	Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
19	HIBCH	interactor	1	0	0	ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
20	HMGB3	interactor	3	1.000	0	HMG_box_2 (PF09011, IPR009071): HMG-box domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
21	KBTBD7	interactor	1	0	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_2 (PF07646, IPR011498): Kelch motif Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_6 (PF13964): Kelch motif
22	KIF2A	interactor	2	0	0	Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain AAA_23 (PF13476): AAA domain CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
23	L3HYPDH	interactor	1	0	0	Pro_racemase (PF05544, IPR008794): Proline racemase
24	LDHB	interactor	10	0.472	15.667	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
25	PDIA4	interactor	9	0.639	7.967	Calsequestrin (PF01216, IPR001393): Calsequestrin Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain FAM176 (PF14851): FAM176 family
26	PGD	oncoprotein	7	0.667	4.833	6PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
27	PPIA	interactor	3	0.667	0.400	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
28	PPP1CA	suppressor	7	0.762	1.967	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
29	PRDX5	interactor	4	0.833	0.400	Redoxin (PF08534, IPR013740): Redoxin NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
30	SCPEP1	interactor	6	0.867	0.667	Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
31	SORD	interactor	7	0.533	6.333	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
32	STK24	interactor	8	0.714	2.300	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain
33	TBCB	interactor	12	0.591	14.833	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
34	UBA5	interactor	2	0	0	Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat ThiF (PF00899, IPR000594): ThiF family
35	XRCC4	interactor	2	0	0	XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
36	YWHAE	oncoprotein	13	0.551	19.719	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
37	YWHAG	protein found in more fusions	10	0.611	7.900	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
38	YWHAH	protein found in more fusions	13	0.561	17.419	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
39	YWHAQ	interactor	9	0.722	5.119	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

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Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors