Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ALDH7A1, CEBPZOS (from a repository: Thu Nov 22 20:36:58 2018)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins8 (20.51 %)
The number (and %) of the tumor suppressors2 (5.13 %)
Total number of binary PPIs (saturation %)136 (18.35 %)
The number (and %) of affected PPIs37 (27.21 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI6.359
Assortativity coefficient-0.3549
The network average Clustering coefficient0.496
The number (and %) of a zero Clustering coefficients10 (25.64 %)
The number (and %) of a zero Betweenness Centrality14 (35.90 %)


List of the fusions

PPI for parental proteins: CEBPZOS,ALDH7A1 All fusions
Proteins found in more fusions EPS8 (see 1 fusions); APP (see 4 fusions); YWHAG (see 1 fusions); YWHAH (see 2 fusions); G6PD (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CEBPZOSinteractor000Ndr (PF03096, IPR004142): Ndr family
2 ALDH7A1parental protein370.131967.419Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4 APPprotein found in more fusions80.38110.019APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ASNSoncoprotein100.60011.200Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6 CAPN2interactor51.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CAPNS1interactor120.59113.352EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CATsuppressor70.6004.733Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
9 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
10 DDA1interactor30.6670.333DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
11 EIF5interactor120.45525.667CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
12 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 ERP44interactor40.6670.800Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
14 FAHD2Ainteractor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
15 FERMT2interactor80.6795.333FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
16 G6PDprotein found in more fusions110.55613.119G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
17 GLAinteractor40.8330.500Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
18 GOT1interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
19 HIBCHinteractor100ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
20 HMGB3interactor31.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
21 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
22 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
23 L3HYPDHinteractor100Pro_racemase (PF05544, IPR008794): Proline racemase
24 LDHBinteractor100.47215.667Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
25 PDIA4interactor90.6397.967Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
26 PGDoncoprotein70.6674.8336PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
27 PPIAinteractor30.6670.400Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
28 PPP1CAsuppressor70.7621.967Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
29 PRDX5interactor40.8330.400Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
30 SCPEP1interactor60.8670.667Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
31 SORDinteractor70.5336.333ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
32 STK24interactor80.7142.300DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
33 TBCBinteractor120.59114.833CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
34 UBA5interactor200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
35 XRCC4interactor200XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
36 YWHAEoncoprotein130.55119.71914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
37 YWHAGprotein found in more fusions100.6117.90014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
38 YWHAHprotein found in more fusions130.56117.41914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
39 YWHAQinteractor90.7225.11914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑