Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPS18P5, TTC7B (from a repository: Sat Aug 17 11:58:24 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins2 (40.00 %)
The number (and %) of the tumor suppressors1 (20.00 %)
Total number of binary PPIs (saturation %)8 (80.00 %)
The number (and %) of affected PPIs3 (37.50 %)
The number of possible different fusions3
PPI diameter3
PPI radius2
The average degree of PPI2.400
Assortativity coefficient0
The network average Clustering coefficient0.533
The number (and %) of a zero Clustering coefficients1 (20.00 %)
The number (and %) of a zero Betweenness Centrality2 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TTC7B,RPS18P5 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); CUL3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TTC7Bparental protein100HrpB1_HrpK (PF09613, IPR013394): Bacterial type III secretion protein (HrpB1_HrpK)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF3808 (PF10300, IPR019412): Protein of unknown function (DUF3808)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 RPS18P5parental protein21.0000NA
3 CUL3protein found in more fusions40.3336.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
4 CUL5suppressor30.6672.000Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
5 EWSR1oncoprotein40.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head

B a c k    t o    T o p ⇑