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Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)121
The number (and %) of the onco-proteins35 (28.93 %)
The number (and %) of the tumor suppressors14 (11.57 %)
Total number of binary PPIs (saturation %)559 (7.70 %)
The number (and %) of affected PPIs120 (21.47 %)
The number of possible different fusions16
PPI diameter5
PPI radius3
The average degree of PPI8.777
Assortativity coefficient-0.3203
The network average Clustering coefficient0.523
The number (and %) of a zero Clustering coefficients10 (8.26 %)
The number (and %) of a zero Betweenness Centrality28 (23.14 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDH2,DERL1 All fusions
Proteins found in more fusions APP (see 5 fusions); EXOC5 (see 1 fusions); SYVN1 (see 1 fusions); VCP (see 4 fusions); KPNB1 (see 2 fusions); APP/ALB (see 2 fusions); CTNNA1 (see 4 fusions); RHO (see 1 fusions); BCAP31 (see 3 fusions); CREBBP (see 6 fusions); XBP1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); UBC (see 7 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDH2parental protein530.0962886.240Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
2 DERL1parental protein670.0914243.566DER1 (PF04511, IPR007599): Der1-like family
3 ACTA1interactor30.6672.355Actin (PF00022, IPR004000, SM00268): Actin
4 AKAP5interactor100WSK (PF03832, IPR001573): WSK motif
5 ALBprotein found in more fusions21.0000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
6 AMFRoncoprotein200.404153.394CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
7 APOBinteractor90.57146.888DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
8 APPprotein found in more fusions280.1141238.922APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ARL6IP5suppressor60.6004.260PRA1 (PF03208, IPR004895): PRA1 family protein
RBD-FIP (PF09457, IPR019018): FIP domain
10 ASGR2interactor30.6670.400UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
11 AVPR2interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 BCAP31protein found in more fusions100.41756.147Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
13 BOConcoprotein31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
ISET-FN3_linker (PF16625): Unstructured linking region I-set and fnIII on Brother of CDO
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
14 CACNA1Cinteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Rer1 (PF03248, IPR004932): Rer1 family
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
15 CAV1suppressor130.372254.955Caveolin (PF01146, IPR001612): Caveolin
16 CCNA2oncoprotein50.8331.729Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
17 CD3Dinteractor40.8330.448DAP10 (PF07213, IPR009861): DAP10 membrane protein
ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
18 CDH11suppressor21.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
19 CDH4suppressor100Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
20 CDONoncoprotein31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Glyco_hydro_76 (PF03663, IPR005198): Glycosyl hydrolase family 76
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
21 CFTRsuppressor120.32778.063ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
22 CLN6interactor21.0000CLN6 (PF15156, IPR029255): Ceroid-lipofuscinosis neuronal protein 6
23 CREBBPsuppressor41.0000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
24 CTNNA1oncoprotein120.509105.597Vinculin (PF01044, IPR006077): Vinculin family
25 CTNNB1oncoprotein190.251639.452Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
26 CTNND1suppressor80.67948.029Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
27 DBN1oncoprotein70.47621.927Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
28 DDR1oncoprotein100Lamprin (PF06403, IPR009437): Lamprin
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
29 DDR2suppressor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
30 DERL2interactor200.337104.761DER1 (PF04511, IPR007599): Der1-like family
31 EDEM1interactor70.47612.215Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
32 EGFRoncoprotein210.221453.045Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
33 EMC1interactor60.46723.349DUF1620 (PF07774, IPR011678): Protein of unknown function (DUF1620)
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
34 EPHX1interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
35 ERLIN2interactor120.409131.703Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
36 ERN1interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
Ribonuc_2-5A (PF06479, IPR010513): Ribonuclease 2-5A
CytochromB561_N (PF09786, IPR019176): Cytochrome B561, N terminal
PQQ_2 (PF13360, IPR002372): PQQ-like domain
37 ESYT1interactor100.356126.663C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
38 ESYT2interactor40.6678.180C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
39 EXOC5protein found in more fusions40.6672.627Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
40 FAF2interactor260.273345.111DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
41 FBXO45interactor31.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
F-box-like (PF12937, IPR001810): F-box-like
42 GAAinteractor31.0000Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
43 GNA12oncoprotein206.632G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
44 GNA13interactor21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
45 HERPUD1oncoprotein80.67917.188Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 HLA-Aoncoprotein110.364133.932DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
47 HM13interactor40.6672.500Peptidase_A22B (PF04258, IPR007369): Signal peptide peptidase
DUF4345 (PF14248, IPR025597): Domain of unknown function (DUF4345)
48 HMOX1interactor31.0000Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
49 HSP90B1suppressor130.41066.560CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
50 IARS2interactor60.46722.131Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
51 JUPsuppressor110.36468.524Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
52 KPNB1protein found in more fusions90.50034.061Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
53 KTN1oncoprotein50.20062.359ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
54 LRRC7interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
55 MBOAT1interactor30.6670.786MBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
DUF3329 (PF11808, IPR021766): Domain of unknown function (DUF3329)
56 MCM2oncoprotein260.1731044.254AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
57 MMGT1interactor70.286127.341MMgT (PF10270, IPR018937): Membrane magnesium transporter
58 MRPL23interactor70.6193.391Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
59 MRPL49interactor80.50039.171Img2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
60 MRPL58interactor100.378108.122RF-1 (PF00472, IPR000352): RF-1 domain
61 MTHFD1interactor170.287313.479FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
62 NACA2interactor30.33339.650NAC (PF01849, IPR002715): NAC domain
63 NEDD1interactor2027.656NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
FliM (PF02154, IPR001689): Flagellar motor switch protein FliM
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
64 NENFinteractor170.26588.282Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
65 NGLY1interactor40.6670.946PUB (PF09409, IPR018997): PUB domain
Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain
PAW (PF04721, IPR006588, SM00613): PNGase C-terminal domain, mannose-binding module PAW
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
66 NTRK1oncoprotein430.1062464.861I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
67 PCinteractor70.38154.360Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
68 PCDHB15oncoprotein21.0000Cadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
69 PDIA4interactor50.200137.769Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
70 PGRMC2suppressor30.33311.738Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
71 PKP4interactor202.355Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
72 PORinteractor60.40030.639FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
73 PPT2interactor160.35850.625Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
74 PRKCDBPsuppressor150.257100.299A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
75 PRPHinteractor30.6670.361Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
76 PTBP3interactor40.50018.276RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
77 PTGS2oncoprotein80.66756.198An_peroxidase (PF03098, IPR002007): Animal haem peroxidase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
78 RAB8Boncoprotein40.6678.300Ras (PF00071, IPR001806, SM00173): Ras family
79 RHOprotein found in more fusions31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
Rhodopsin_N (PF10413, IPR019477): Amino terminal of the G-protein receptor rhodopsin
80 RNF103interactor21.0000VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
81 RNF185interactor110.40045.272zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
82 RNF5interactor100.50016.681zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
83 RPL14interactor100.66725.595KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
84 RPL21interactor100.6678.184Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
85 RPL3interactor130.526144.408Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
86 RPL32interactor110.56431.180Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
87 RPL8interactor100.68932.522Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
88 RPS16interactor110.61867.103Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
89 RPS26interactor120.60679.923Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
90 RTN4suppressor60.40059.703CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
91 RYKoncoprotein50.40042.978Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
92 SARS2interactor70.61914.547tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312)
DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
93 SEC22Binteractor40.6674.711Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
94 SEL1Loncoprotein150.390217.631fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
95 SELENOSinteractor130.52624.392Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
96 SERPINA1oncoprotein31.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
97 SHHoncoprotein60.9000.400HH_signal (PF01085, IPR000320): Hedgehog amino-terminal signalling domain
Hint (PF01079, IPR001767): Hint module
98 SKP1oncoprotein70.476138.772Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
99 SPTBN1suppressor60.53310.936CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
100 SSR4interactor60.33324.052TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
101 SUPT5Hinteractor40.6677.935KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
102 SVIPinteractor51.0000SVIP (PF15811, IPR031632): Small VCP/p97-interacting protein
103 SYVN1protein found in more fusions230.294235.056Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
104 TCF25interactor100Tcf25 (PF04910, IPR006994): Transcriptional repressor TCF25
DUF4604 (PF15377, IPR027911): Domain of unknown function (DUF4604)
105 TCTN3interactor170.191179.291DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
106 TEPSINinteractor21.0000ENTH (PF01417, IPR001026, SM00273): ENTH domain
107 TMEM129interactor80.7622.039Tmpp129 (PF10272, IPR018801): Putative transmembrane protein precursor
108 TMEM256interactor100DUF423 (PF04241, IPR006696): Protein of unknown function (DUF423)
DUF2648 (PF10855, IPR022561): Protein of unknown function (DUF2648)
109 TPM4oncoprotein60.40013.743Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
110 TRAM1interactor80.39335.641TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
DUF3671 (PF12420, IPR022139): Protein of unknown function
111 UBCprotein found in more fusions200.246505.850ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
112 UBE2J1interactor110.47316.611UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
113 UBXN4interactor70.6194.900Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
114 UBXN6interactor70.52416.117PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
115 USP19interactor70.47623.904CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
116 VCPprotein found in more fusions360.1701239.413AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
117 XBP1protein found in more fusions40.66714.617DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF2630 (PF10944, IPR020311): Protein of unknown function (DUF2630)
118 XRCC3oncoprotein60.20060.895Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
119 YIF1Binteractor31.0000YIF1 (PF03878, IPR005578): YIF1
120 YOD1interactor70.8105.557OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
121 ZFAND2Binteractor40.8332.670UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger

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