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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: Z46376 is the fusion of parental proteins FAM50A, HK2 (from a repository: Thu Apr 20 21:54:43 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins13 (28.89 %)
The number (and %) of the tumor suppressors4 (8.89 %)
Total number of binary PPIs (saturation %)121 (12.22 %)
The number (and %) of affected PPIs44 (36.36 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.533
Assortativity coefficient-0.3315
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients9 (20.00 %)
The number (and %) of a zero Betweenness Centrality25 (55.56 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FAM50A,HK2 All fusions
: Z46376;
Proteins found in more fusions PRKCE (see 3 fusions); UBQLN1 (see 2 fusions); HSP90AA1 (see 2 fusions); PPME1 (see 1 fusions); APP (see 4 fusions); EGFR (see 2 fusions); ARIH2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 Z46376chimera440.0611596.267Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
2 APPprotein found in more fusions80.42911.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 ARIH2protein found in more fusions60.5004.667IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
4 BUB3interactor50.6002.300WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
5 C15orf48interactor21.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
6 CNBPoncoprotein21.0000zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain
7 COQ9interactor31.0000COQ9 (PF08511, IPR013718): COQ9
8 EGFRoncoprotein120.41822.467Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 ELAVL1oncoprotein90.32116.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 FBXO6interactor70.5246.467FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
11 FNTAinteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat
TPR_14 (PF13428): Tetratricopeptide repeat
DUF4219 (PF13961, IPR025314): Domain of unknown function (DUF4219)
12 FOXB1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
13 FOXH1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
14 FOXI2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
15 FOXL1oncoprotein100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
16 FOXL2suppressor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 H2AFVinteractor30.6670.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
18 HEXBinteractor41.0000Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
19 HSP90AA1oncoprotein110.33325.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
20 HYOU1interactor40.8330.333HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
21 IPO5interactor70.4298.567HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
22 IRF3suppressor40.6670.400IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
23 ITGA4interactor70.3337.400FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
24 MAGEA12interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
25 MARSoncoprotein50.6001.900Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
26 NDUFA4interactor31.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
27 NTRK1oncoprotein150.22062.700I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
28 NUBP1interactor40.6671.667DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
29 NUDCD3interactor21.0000CS (PF04969, IPR007052): CS domain
DUF1737 (PF08410, IPR013619): Domain of unknown function (DUF1737)
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
30 PARK2suppressor60.7001.567IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 PDLIM1interactor41.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
32 PPME1protein found in more fusions31.0000Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
33 PRKCEsuppressor50.6670.900C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
34 PYGLinteractor200Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
35 RAD18interactor200PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
36 SEPT10interactor21.0000Septin (PF00735, IPR000038): Septin
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
37 SEPT6oncoprotein21.0000Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
38 SLC2A4interactor21.0000Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
39 SRMinteractor30.6670.400Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
40 TBCBinteractor31.0000CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
41 TCEB2interactor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 TPP2interactor21.0000Peptidase_S8 (PF00082, IPR000209): Subtilase family
TPPII (PF12580, IPR022229): Tripeptidyl peptidase II
TPPII_N (PF12583, IPR022232): Tripeptidyl peptidase II N terminal
43 UBQLN1protein found in more fusions60.4005.167Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
44 UBQLN4interactor31.0000CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
45 WDR61interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EWSR1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
2 FAM50Aparental proteinXAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
3 HK2parental proteinHexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
4 MED20interactorMed20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
5 MED4interactorMed4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
6 METTL16interactorMethyltransf_10 (PF05971, IPR010286): Protein of unknown function (DUF890)
7 MOV10interactorAAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
8 NXF1interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat

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