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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: Y15920 is the fusion of parental proteins PDGFB, COL1A1 (from a repository: Sat Nov 12 09:31:58 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins14 (28.57 %)
The number (and %) of the tumor suppressors8 (16.33 %)
Total number of binary PPIs (saturation %)108 (9.18 %)
The number (and %) of affected PPIs48 (44.44 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.878
Assortativity coefficient-0.5014
The network average Clustering coefficient0.459
The number (and %) of a zero Clustering coefficients15 (30.61 %)
The number (and %) of a zero Betweenness Centrality26 (53.06 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PDGFB,COL1A1 All fusions
: Y15920;
Proteins found in more fusions COL4A1 (see 3 fusions); PKD1 (see 1 fusions); NID1 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 Y15920chimera480.0422035.367Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
2 ADIPOQinteractor200C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
3 ATP13A2interactor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
MARVEL (PF01284, IPR008253): Membrane-associating domain
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
4 BARD1suppressor40.6671.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5 BRCA1suppressor40.6671.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 C12orf57interactor100P_C10 (PF14974, IPR026317): Protein C10
7 CAMKMTinteractor30.6671.000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
8 CAPN1interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CD200R1interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Fig1 (PF12351): Ca2+ regulator and membrane fusion protein Fig1
10 COL1A2oncoprotein40.5002.667COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
11 COL2A1interactor60.3337.800COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
12 COL3A1oncoprotein60.3336.800COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
13 COL4A1protein found in more fusions80.33311.800C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
14 COL5A1interactor50.4003.133COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
15 COL6A1interactor30.6670.333Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
16 COL7A1oncoprotein31.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
DUF4249 (PF14054, IPR025345): Domain of unknown function (DUF4249)
DUF4992 (PF16383, IPR032155): Domain of unknown function
17 DNM3interactor100Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
18 ELAVL1oncoprotein80.33314.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 ERAL1interactor30.6670.667GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
KH_1 (PF00013, IPR004088, SM00322): KH domain
20 GIPC2interactor200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
21 HSPG2oncoprotein40.5002.333C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
hEGF (PF12661, IPR013032): Human growth factor-like EGF
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
22 IGFBP3suppressor100IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
23 ITGA2interactor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
24 ITGB1suppressor50.6003.667EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
25 LRP1interactor21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
TadE (PF07811, IPR012495): TadE-like protein
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
26 LYVE1interactor100Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
BtrH_N (PF14399, IPR026935): Butirosin biosynthesis protein H, N-terminal
27 MAGinteractor60.3335.567C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
28 MATN2interactor200VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Matrilin_ccoil (PF10393, IPR019466): Trimeric coiled-coil oligomerisation domain of matrilin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
29 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
30 MFSD13Ainteractor21.0000MFS_2 (PF13347): MFS/sugar transport protein
31 MMP2oncoprotein31.0000Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
32 NID1protein found in more fusions31.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
33 NID2interactor30.6670.667EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
34 NRP1interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF3481 (PF11980, IPR022579): C-terminal domain of neuropilin glycoprotein
35 OTUB1interactor30.6671.000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
36 PDAP1interactor21.0000PP28 (PF10252, IPR019380): Casein kinase substrate phosphoprotein PP28
37 PDGFAoncoprotein100.20030.567PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
38 PDGFRAoncoprotein40.6671.000Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
39 PDGFRBoncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
40 PKD1suppressor31.0000Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
41 PRELPinteractor30.6670.667LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
42 RNH1suppressor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Metallothio_Euk (PF12749, IPR024306): Eukaryotic metallothionein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
43 SPARCsuppressor30.6670.400FOLN (PF09289, IPR015369, SM00274): Follistatin/Osteonectin-like EGF domain
Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
44 THBS1suppressor100.26729.567EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
45 TMTC4interactor21.0000DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
46 TXNoncoprotein21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
47 UBCprotein found in more fusions40.6671.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
48 UBXN11interactor100DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
49 VWFinteractor100Antistasin (PF02822, IPR004094): Antistasin family
C8 (PF08742, IPR014853, SM00832): C8 domain
Metallothio_5 (PF02067, IPR000966): Metallothionein family 5
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
VWA_N2 (PF16164, IPR032361): VWA N-terminal

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 COL1A1parental proteinCOLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
2 PDGFBparental proteinPDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region

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