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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)108
The number (and %) of the onco-proteins40 (37.04 %)
The number (and %) of the tumor suppressors33 (30.56 %)
Total number of binary PPIs (saturation %)636 (11.01 %)
The number (and %) of affected PPIs107 (16.82 %)
The number of possible different fusions27
PPI diameter2
PPI radius1
The average degree of PPI10.796
Assortativity coefficient-0.2849
The network average Clustering coefficient0.547
The number (and %) of a zero Clustering coefficients5 (4.63 %)
The number (and %) of a zero Betweenness Centrality20 (18.52 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RARA All fusions
: X06538;
Proteins found in more fusions POU2F1 (see 1 fusions); FOXO1 (see 1 fusions); MAPK1 (see 1 fusions); NPM1 (see 1 fusions); HDAC4 (see 1 fusions); SQSTM1 (see 5 fusions); SIAH1 (see 4 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); SP1 (see 1 fusions); RUNX1 (see 1 fusions); CREBBP (see 6 fusions); UBQLN1 (see 2 fusions); KAT2B (see 1 fusions); SKI (see 1 fusions); RXRA (see 2 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PRDX6 (see 1 fusions); SUV39H1 (see 1 fusions); PSMC5 (see 2 fusions); SNW1 (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 X06538chimera1070.0847253.630zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
2 ACTN4interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 AJUBAoncoprotein30.6671.000LIM (PF00412, IPR001781, SM00132): LIM domain
4 AKT1oncoprotein150.50517.072PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ARID1Asuppressor40.6671.333ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
6 ARID5Aoncoprotein21.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
7 ARNTLsuppressor90.6675.213HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
8 BAG1oncoprotein21.0000BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
9 CBX5suppressor70.3335.586Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
10 CCND3oncoprotein50.5004.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
11 CEBPAsuppressor120.40019.729Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
12 CLOCKinteractor90.6678.080DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PAS (PF00989, IPR013767, SM00091): PAS fold
RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
PAS_11 (PF14598): PAS domain
FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
13 CREBBPsuppressor360.271241.375Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
14 E2F1suppressor130.57710.444Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
15 EP300oncoprotein360.289214.474Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
16 EZH2suppressor170.40039.245CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
17 FASsuppressor90.28616.733Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
18 FN1oncoprotein120.31835.041fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
19 FOXO1suppressor100.6672.760K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
20 GADD45Asuppressor70.4674.483Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
21 GADD45Gsuppressor50.5003.667Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
22 HACE1suppressor200HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
23 HDAC1suppressor340.244241.598FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
24 HDAC2suppressor270.308117.960Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
25 HDAC3suppressor280.296128.809Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
26 HDAC4oncoprotein140.53814.629Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
27 HMGA1oncoprotein100.6226.405AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
28 HNRNPUinteractor130.37233.169CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
29 HRinteractor40.6670.265JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
30 IRX4interactor100Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
31 ITGB1BP2interactor100CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
32 KAT2Bprotein found in more fusions190.42539.862Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
33 KDM5Asuppressor51.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
FRG1 (PF06229, IPR010414): FRG1-like domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
34 KLF5suppressor100.6893.478zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
35 LIMD1suppressor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
36 LRIF1interactor60.4005.000LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
37 MAPK1oncoprotein120.45516.454Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAPK6oncoprotein50.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
39 MBD3interactor70.7334.000DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
40 MDM2oncoprotein230.29496.624Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
41 MECRinteractor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
42 MED1interactor120.36419.018Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
43 MED25interactor70.6672.424Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1
Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing
Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
44 MED6interactor50.6002.400Med6 (PF04934, IPR007018): MED6 mediator sub complex component
Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
45 MMS19interactor40.5002.667DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
46 MRTO4interactor50.6002.119Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
47 MTA2interactor70.8101.619BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
48 NCOA1oncoprotein200.36364.686DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
49 NCOA2oncoprotein110.58210.346DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
50 NCOA3oncoprotein200.33271.817DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
51 NCOA6oncoprotein150.48419.856DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Presenilin (PF01080, IPR001108): Presenilin
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
52 NCOR1oncoprotein210.42955.409BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
53 NCOR2oncoprotein240.42066.107CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
54 NKX2-1oncoprotein51.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
55 NPAS2suppressor80.8570.932HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
DehI (PF10778, IPR019714): Halocarboxylic acid dehydrogenase DehI
PAS_11 (PF14598): PAS domain
56 NPM1suppressor180.40445.352Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
57 NR0B2suppressor110.36415.461Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
58 NR1H2oncoprotein160.36744.948zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
59 NR2E3interactor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
60 NRBF2interactor21.0000NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
61 NRIP1oncoprotein80.4297.384ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
62 NSD1oncoprotein21.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
63 PARP1suppressor230.36875.741BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
64 PHF8interactor30.6670.500JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
65 PIN1suppressor110.38220.177Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
66 PMLsuppressor380.212350.379zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
67 POU2F1protein found in more fusions80.7621.298Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
68 PRAM1interactor50.6002.452hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
69 PRAMEinteractor31.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
70 PRDX6protein found in more fusions41.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
71 PSMC5protein found in more fusions110.4679.805AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
72 RFC4interactor60.5335.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
73 RUNX1suppressor130.60610.840Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
74 RUVBL1oncoprotein50.5001.008TIP49 (PF06068, IPR010339): TIP49 C-terminus
75 RXRAoncoprotein410.177476.621zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
76 RXRBinteractor40.8330.500zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
77 RXRGinteractor60.5335.036zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
78 SAP130interactor41.0000SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
79 SIAH1suppressor70.5335.286Sina (PF03145, IPR018121): Seven in absentia protein family
80 SIRT1suppressor220.33364.875DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
81 SKIoncoprotein110.53310.471c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
82 SMARCD3interactor40.5001.900SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
83 SNRNP40interactor40.8330.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
84 SNW1protein found in more fusions200.26383.847SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
85 SP1protein found in more fusions220.44850.311zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
86 SPI1suppressor70.6673.297Ets (PF00178, IPR000418, SM00413): Ets-domain
p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
87 SQSTM1oncoprotein100.38917.356PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
88 SRConcoprotein80.6671.858Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
89 SRFinteractor130.59111.435SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
90 SUMO2interactor130.36430.787Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
91 SUV39H1protein found in more fusions130.40919.880Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
92 SUZ12suppressor140.43627.998DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
93 TADA3interactor40.8330.222GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
94 TBL1XR1oncoprotein70.5245.544LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
95 TDGinteractor60.7330.977Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
96 TEKT4interactor21.0000Tektin (PF03148, IPR000435): Tektin family
97 TMEM54interactor21.0000BCLP (PF12304, IPR020977): Beta-casein like protein
98 TNIP1interactor50.5001.233ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
99 TOP2Boncoprotein80.7142.747CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DASH_Spc19 (PF08287, IPR013251): Spc19
DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
100 TRIM24suppressor50.8330.222PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
zf-MYND (PF01753, IPR002893): MYND finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
Imm68 (PF15583, IPR028276): Immunity protein 68
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
101 TRIM32suppressor40.6670.667NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
102 TRIP4interactor80.6793.266ASCH (PF04266, IPR007374, SM01022): ASCH domain
UxaC (PF02614, IPR003766): Glucuronate isomerase
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
103 UBE3Aoncoprotein90.32113.177HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
104 UBQLN1protein found in more fusions70.3338.067Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
105 USP7oncoprotein90.5009.600MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
106 WTIPinteractor100DUF983 (PF06170, IPR009325): Protein of unknown function (DUF983)
LIM (PF00412, IPR001781, SM00132): LIM domain
107 WWOXsuppressor31.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
108 ZBTB16suppressor160.47628.123BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 RARAparental proteinzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor

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