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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)66
The number (and %) of the onco-proteins12 (18.18 %)
The number (and %) of the tumor suppressors5 (7.58 %)
Total number of binary PPIs (saturation %)158 (7.37 %)
The number (and %) of affected PPIs65 (41.14 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.061
Assortativity coefficient-0.4668
The network average Clustering coefficient0.445
The number (and %) of a zero Clustering coefficients20 (30.30 %)
The number (and %) of a zero Betweenness Centrality31 (46.97 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SAT1 All fusions
: W39276;
Proteins found in more fusions HSPB1 (see 4 fusions); KAT5 (see 3 fusions); CHD3 (see 1 fusions); EEF1G (see 1 fusions); LUC7L2 (see 2 fusions); RACK1 (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 W39276chimera650.0333823.467Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
2 ABCB8oncoprotein100ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
3 APLP1interactor60.5336.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 B4GALT3interactor100Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
5 C14orf1interactor30.6670.400Erg28 (PF03694, IPR005352): Erg28 like protein
6 C19orf25interactor100UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
7 CASP7interactor40.6671.000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 CCDC148interactor100DMA (PF03474, IPR005173): DMRTA motif
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
FKS1_dom1 (PF14288, IPR026899): 1,3-beta-glucan synthase subunit FKS1, domain-1
9 CCDC90Binteractor100DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
10 CCHCR1interactor40.6671.000HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
11 CEP126interactor21.0000Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
12 CHD3oncoprotein80.42910.067CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
13 COPS6interactor40.6671.000DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
14 CRMP1interactor40.6670.400Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
15 DDX39Ainteractor200DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
16 DGKZinteractor100C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DAGK_acc (PF00609, IPR000756, SM00045): Diacylglycerol kinase accessory domain
DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
17 DMRT3interactor21.0000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
DMA (PF03474, IPR005173): DMRTA motif
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
18 DNPEPinteractor31.0000Peptidase_M18 (PF02127, IPR001948): Aminopeptidase I zinc metalloprotease (M18)
19 EEF1Gprotein found in more fusions40.6671.000EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
20 EPHB6suppressor30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Phage_holin_5_1 (PF06946, IPR009708): Bacteriophage A118-like holin, Hol118
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
21 EVA1Ainteractor21.0000FAM176 (PF14851): FAM176 family
22 FAM156Ainteractor100PGC7_Stella (PF15549, IPR029096): PGC7/Stella/Dppa3 domain
23 FAM69Binteractor100UPF0175 (PF03683, IPR005368): Uncharacterised protein family (UPF0175)
PIP49_C (PF12260, IPR022049): Protein-kinase domain of FAM69
PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69
24 FAM86C1interactor100FAM86 (PF14904, IPR029426): Family of unknown function
25 FTSJ3interactor100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
26 GBP2interactor40.5002.400GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
27 GDF9interactor21.0000CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
28 HIF1Asuppressor60.4677.667Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
29 HOXB6interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
30 HOXB9interactor100Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31 HSPB1oncoprotein70.3339.400HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
32 HSPE1interactor90.25024.667Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
33 INO80Cinteractor100YL1_C (PF08265, IPR013272, SM00993): YL1 nuclear protein C-terminal domain
34 JUNBoncoprotein100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
35 KAT5suppressor60.6003.400MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
36 KAT7interactor30.6670.400MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
zf-met (PF12874): Zinc-finger of C2H2 type
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
37 KCNA4interactor21.0000GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
BTB_2 (PF02214, IPR003131): BTB/POZ domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
38 LNX1interactor50.5003.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
39 LRIF1interactor100.30621.000LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
40 LUC7L2protein found in more fusions70.4008.667LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
41 MED31interactor30.6671.000Med31 (PF05669, IPR008831): SOH1
42 MRPL9interactor100Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
43 MTA1oncoprotein40.8330.667BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
44 NIF3L1interactor40.6671.000NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
45 NMRK2interactor100MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
AAA_18 (PF13238): AAA domain
46 PLGRKTinteractor21.0000DUF2368 (PF10166, IPR019319): Uncharacterised conserved protein (DUF2368)
47 PRDX2interactor100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
48 PTNoncoprotein70.4008.667PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
49 RACK1suppressor50.5003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
50 RBM17interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
Slu7 (PF11708, IPR021715): Pre-mRNA splicing Prp18-interacting factor
51 RELoncoprotein40.5003.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
52 RELAoncoprotein70.4677.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
53 RPLP1interactor60.4005.667Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
54 SAT2interactor31.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
55 SEPHS1interactor70.3338.000AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
56 SETDB1interactor40.6671.667MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
57 SNAI2oncoprotein21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
KCNQ2_u3 (PF16642): Unstructured region on Potassium channel subunit alpha KvLQT2
58 TACO1interactor100Transcrip_reg (PF01709, IPR002876): Transcriptional regulator
59 TCF25interactor100Tcf25 (PF04910, IPR006994): Transcriptional repressor TCF25
DUF4604 (PF15377, IPR027911): Domain of unknown function (DUF4604)
60 TLE1interactor40.6671.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
61 TP53suppressor130.24246.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62 TSC22D4interactor40.5003.000AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
63 TUBB2Ainteractor30.6671.000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
64 UNC119interactor40.5002.400GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
65 VASPinteractor31.0000ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
66 ZHX1interactor50.6671.667Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EIF3DinteractoreIF-3_zeta (PF05091, IPR007783): Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
2 FUNDC2interactorFUN14 (PF04930, IPR007014): FUN14 family
3 RBM48interactorDUF2284 (PF10050, IPR019271): Predicted metal-binding protein (DUF2284)
4 SARAFinteractorSARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
5 SAT1parental proteinAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
6 UTP14AinteractorUtp14 (PF04615, IPR006709): Utp14 protein
7 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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