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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: W28286 is the fusion of parental proteins TSPAN3 (from a repository: Tue Aug 20 13:18:41 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins9 (25.71 %)
The number (and %) of the tumor suppressors3 (8.57 %)
Total number of binary PPIs (saturation %)49 (8.24 %)
The number (and %) of affected PPIs34 (69.39 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.514
Assortativity coefficient-0.6144
The network average Clustering coefficient0.362
The number (and %) of a zero Clustering coefficients20 (57.14 %)
The number (and %) of a zero Betweenness Centrality31 (88.57 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TSPAN3 All fusions
: W28286;
Proteins found in more fusions GABARAP (see 2 fusions); EWSR1 (see 2 fusions); FGFR2 (see 3 fusions); CSNK1G3 (see 1 fusions); FGFR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 W28286chimera340.0181090.000Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF2244 (PF10003, IPR019253): Integral membrane protein (DUF2244)
DUF2892 (PF11127, IPR021309): Protein of unknown function (DUF2892)
2 ACVR1Boncoprotein100Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 AGPAT3interactor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
4 ARL17Ainteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
ARL17 (PF15840, IPR031687): ADP-ribosylation factor-like protein 17
5 CC2D1Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Snf7 (PF03357, IPR005024): Snf7
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
6 CD320interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF3678 (PF12435, IPR022146): Protein of unknown function (DUF3678)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
7 CD63interactor30.6671.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
8 CDC6oncoprotein100Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
9 CSNK1G3protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
10 EPHA4interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11 EPHA5interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
12 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
13 FAM189Binteractor100CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
14 FGFR1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
15 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
16 GABARAPsuppressor31.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
17 GOLGA7interactor100Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
18 IFNGR1interactor21.0000IFNGR1 (PF07140, IPR021126): Interferon gamma receptor (IFNGR1)
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
19 KDSRoncoprotein1007kD_coat (PF02495, IPR003411): 7kD viral coat protein
adh_short (PF00106, IPR002198): short chain dehydrogenase
20 LPAR1oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
21 LRP10interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Syndecan (PF01034, IPR027789): Syndecan domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
22 MAP1LC3B2interactor100Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
23 NDFIP1interactor21.0000DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Comm (PF15957, IPR031878): Commissureless
24 NDFIP2interactor100DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
25 NOTCH3suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
26 PI4K2Ainteractor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
27 RDH14interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
28 RNF13interactor21.0000DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
29 RNF149interactor21.0000PA (PF02225, IPR003137): PA domain
UPF0233 (PF06781, IPR009619): Uncharacterised protein family (UPF0233)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
30 SDCBPinteractor30.6671.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
31 SNX17interactor100FERM_M (PF00373, IPR019748): FERM central domain
PX (PF00787, IPR001683, SM00312): PX domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
32 STX6interactor100Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
33 TNFRSF10Bsuppressor60.33310.000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
34 UGCGinteractor21.0000Glyco_transf_21 (PF13506, IPR025993): Glycosyl transferase family 21
35 ZDHHC9interactor21.0000UPF0182 (PF03699, IPR005372): Uncharacterised protein family (UPF0182)
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
DUF4714 (PF15833, IPR031674): Domain of unknown function (DUF4714)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 TSPAN3parental proteinHum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family

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