Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: W00863 is the fusion of parental proteins APOB, MT1G (from a repository: Tue Feb 6 07:26:07 2018)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins16 (36.36 %)
The number (and %) of the tumor suppressors3 (6.82 %)
Total number of binary PPIs (saturation %)105 (11.10 %)
The number (and %) of affected PPIs43 (40.95 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.182
Assortativity coefficient-0.5352
The network average Clustering coefficient0.393
The number (and %) of a zero Clustering coefficients20 (45.45 %)
The number (and %) of a zero Betweenness Centrality27 (61.36 %)


List of the fusions

PPI for parental proteins: MT1G,APOB All fusions
: W00863;
Proteins found in more fusions VCP (see 4 fusions); PRDX4 (see 1 fusions); PAX6 (see 2 fusions); CALR (see 6 fusions); EGFR (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 W00863chimera430.0541599.019DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
T4SS (PF07996, IPR014158): Type IV secretion system proteins
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
2 AKT2oncoprotein30.6671.000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ANLNoncoprotein21.0000Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
4 APOA1interactor50.5002.667ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
5 ARFGAP1interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
6 ARXinteractor100CbiD (PF01888, IPR002748): CbiD
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAR (PF03826, IPR003654): OAR domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
7 AUP1interactor41.0000CUE (PF02845, IPR003892, SM00546): CUE domain
8 B3GALT2interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
9 BGNoncoprotein100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
10 CALCRoncoprotein1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
11 CALRoncoprotein60.9000.286Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
12 CANXinteractor60.7332.619Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
13 CRKLoncoprotein21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 DERL1interactor80.7622.352DER1 (PF04511, IPR007599): Der1-like family
15 EGFRoncoprotein120.38228.333Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 FAF2interactor100.6676.352DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
17 HSP90B1suppressor80.7143.619CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
18 HSPA5oncoprotein110.40023.519HSP70 (PF00012, IPR013126): Hsp70 protein
19 LIPCinteractor100Lipase (PF00151, IPR013818): Lipase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
20 LRP6interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
21 MLF1oncoprotein100Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
22 MTTPinteractor100Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
23 MYH9suppressor40.6672.000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
24 MZT1interactor100Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
MOZART1 (PF12554, IPR022214): Mitotic-spindle organizing gamma-tubulin ring associated
25 P2RY12interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
26 P2RY14oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
Ni_hydr_CYTB (PF01292, IPR011577): Prokaryotic cytochrome b561
27 PAX6suppressor31.0000PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
28 PDIA4interactor100Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
29 PLIN2interactor100Perilipin (PF03036, IPR004279): Perilipin family
30 PPIBinteractor21.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
31 PRDX4protein found in more fusions200AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
32 PSMD14interactor21.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
33 RAD21oncoprotein100Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
34 SEC61A1interactor40.8330.667DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430)
SecY (PF00344, IPR002208): SecY translocase
Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
35 SEC61Binteractor50.8330.667Sec61_beta (PF03911, IPR016482): Sec61beta family
36 SELENOSinteractor51.0000Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
37 SLC18A1interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
38 SLC38A6interactor100Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
39 SMAD3oncoprotein40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
40 SYVN1interactor90.6436.667Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
41 TMEM41Binteractor100DUF788 (PF05620, IPR008506): Protein of unknown function (DUF788)
SNARE_assoc (PF09335, IPR015414): SNARE associated Golgi protein
42 UCHL5oncoprotein60.4005.667Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
43 VCPprotein found in more fusions120.47321.567AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
44 YIPF2interactor100Yip1 (PF04893, IPR006977): Yip1 domain
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)

B a c k    t o    T o p ⇑

List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APOBparental proteinDUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
2 MT1Gparental proteinMetallothio (PF00131, IPR003019): Metallothionein
3 SHBGoncoproteinLaminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
4 SPINK7suppressorKazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain

B a c k    t o    T o p ⇑