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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: T07193 is the fusion of parental proteins NEUROD2, IRF2BP2 (from a repository: Sat Feb 24 09:48:39 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)2
The number (and %) of the onco-proteins1 (50.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)1 (100.00 %)
The number (and %) of affected PPIs1 (100.00 %)
The number of possible different fusions1
PPI diameter1
PPI radius1
The average degree of PPI1.000
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients2 (100.00 %)
The number (and %) of a zero Betweenness Centrality2 (100.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NEUROD2,IRF2BP2 All fusions
: T07193;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 T07193chimera100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Neuro_bHLH (PF12533, IPR022575): Neuronal helix-loop-helix transcription factor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
2 CCNL2interactor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CUTCinteractorCutC (PF03932, IPR005627): CutC family
2 DEKoncoproteinDEK_C (PF08766, IPR014876): DEK C terminal domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
SAP (PF02037, IPR003034, SM00513): SAP domain
Bud13 (PF09736, IPR018609): Pre-mRNA-splicing factor of RES complex
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
3 EIF4HinteractoreIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 FOSL2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
6 GANABsuppressorGlyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
7 IRF2interactorIRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
8 IRF2BP2parental proteinzf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Bd3614_N (PF14442, IPR025854): Bd3614-like deaminase N-terminal
9 IRF2BPLinteractorCalpain_inhib (PF00748, IPR001259): Calpain inhibitor
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
10 NEUROD2parental proteinHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SipA (PF09052, IPR015138): Salmonella invasion protein A
Neuro_bHLH (PF12533, IPR022575): Neuronal helix-loop-helix transcription factor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
11 NFATC2suppressorRHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
12 NTRK1oncoproteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
13 PKN1interactorC2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
14 RBM39oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
15 SH3KBP1interactorTmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 SIRT6suppressorSIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
17 TK1oncoproteinTK (PF00265, IPR001267, SM00203): Thymidine kinase
18 UPRTinteractorUPRTase (PF14681, IPR029057): Uracil phosphoribosyltransferase
19 VGLL4interactorVg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4

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