Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	42
The number (and %) of the onco-proteins	14 (33.33 %)
The number (and %) of the tumor suppressors	8 (19.05 %)
Total number of binary PPIs (saturation %)	114 (13.24 %)
The number (and %) of affected PPIs	41 (35.96 %)
The number of possible different fusions	3
PPI diameter	2
PPI radius	1
The average degree of PPI	5.190
Assortativity coefficient	-0.3616
The network average Clustering coefficient	0.649
The number (and %) of a zero Clustering coefficients	5 (11.90 %)
The number (and %) of a zero Betweenness Centrality	21 (50.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CDH2,PEA15	All fusions : T06950;
Proteins found in more fusions	CREBBP (see 6 fusions); UBC (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	T06950	chimera	41	0.083	1199.452	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin (PF00028, IPR002126, SM00112): Cadherin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain Cadherin_3 (PF16184): Cadherin-like
2	ACTA1	interactor	2	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
3	BOC	oncoprotein	3	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain ISET-FN3_linker (PF16625): Unstructured linking region I-set and fnIII on Brother of CDO Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
4	CCNA2	oncoprotein	5	0.833	0.667	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
5	CDH11	suppressor	2	1.000	0	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family Cadherin (PF00028, IPR002126, SM00112): Cadherin domain Cadherin_3 (PF16184): Cadherin-like
6	CDH4	suppressor	1	0	0	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain Cadherin_3 (PF16184): Cadherin-like
7	CDON	oncoprotein	3	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Glyco_hydro_76 (PF03663, IPR005198): Glycosyl hydrolase family 76 I-set (PF07679, IPR013098): Immunoglobulin I-set domain Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
8	CREBBP	suppressor	4	1.000	0	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9	CTNNB1	oncoprotein	13	0.244	56.667	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
10	CTNND1	suppressor	3	1.000	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2 Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
11	DBN1	oncoprotein	6	0.600	3.167	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
12	DDR1	oncoprotein	1	0	0	Lamprin (PF06403, IPR009437): Lamprin Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
13	DDR2	suppressor	2	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain TMEM154 (PF15102, IPR028064): TMEM154 protein family
14	FBXO45	interactor	3	1.000	0	SPRY (PF00622, IPR003877, SM00449): SPRY domain F-box-like (PF12937, IPR001810): F-box-like
15	GAA	interactor	3	1.000	0	Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31 Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase DUF5110 (PF17137): Domain of unknown function (DUF5110)
16	IARS2	interactor	4	0.833	0.500	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
17	IQCB1	interactor	2	1.000	0	DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
18	JUP	suppressor	7	0.476	8.452	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
19	KTN1	oncoprotein	2	1.000	0	ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Fez1 (PF06818): Fez1 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper IncA (PF04156, IPR007285): IncA protein OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase Spectrin (PF00435, IPR002017): Spectrin repeat TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2 Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
20	LGR4	interactor	3	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
21	LRRC7	interactor	1	0	0	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
22	MTHFD1	interactor	10	0.378	20.833	FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
23	NENF	interactor	11	0.255	33.333	Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
24	NTRK1	oncoprotein	21	0.168	142.500	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
25	PC	interactor	4	0.833	0.333	Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain HMGL-like (PF00682, IPR000891): HMGL-like PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
26	PDIA4	interactor	3	0.667	0.286	Calsequestrin (PF01216, IPR001393): Calsequestrin Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain FAM176 (PF14851): FAM176 family
27	PKP4	interactor	1	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat
28	PRKCDBP	suppressor	9	0.389	16.333	A1_Propeptide (PF07966, IPR012848): A1 Propeptide PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
29	PRPH	interactor	3	0.667	0.500	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
30	PTBP3	interactor	3	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31	RAB8B	oncoprotein	3	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
32	RPL14	interactor	4	0.667	1.286	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
33	RPL8	interactor	3	1.000	0	Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
34	RYK	oncoprotein	3	0.667	0.500	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
35	SARS2	interactor	5	0.700	1.119	tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312) DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
36	SKP1	oncoprotein	6	0.467	7.167	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
37	SPTBN1	suppressor	5	0.600	1.786	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
38	SSR4	interactor	3	1.000	0	TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta) OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
39	SUPT5H	interactor	3	0.667	0.286	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
40	TMEM256	interactor	1	0	0	DUF423 (PF04241, IPR006696): Protein of unknown function (DUF423) DUF2648 (PF10855, IPR022561): Protein of unknown function (DUF2648)
41	TPM4	oncoprotein	4	0.667	0.833	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
42	UBC	protein found in more fusions	7	0.400	8.000	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ABCD4	interactor	ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2 ABC_tran (PF00005, IPR003439): ABC transporter PhoH (PF02562, IPR003714): PhoH-like protein
2	CASP8	suppressor	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
3	CDH2	parental protein	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain Cadherin_3 (PF16184): Cadherin-like
4	CEP170	interactor	FHA (PF00498, IPR000253, SM00240): FHA domain DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254) CEP170_C (PF15308, IPR029300): CEP170 C-terminus
5	CTNNA1	oncoprotein	Vinculin (PF01044, IPR006077): Vinculin family
6	EXOC5	interactor	Sec10 (PF07393, IPR009976): Exocyst complex component Sec10 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
7	FADD	suppressor	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
8	FBF1	interactor	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family YlqD (PF11068, IPR021297): YlqD protein KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
9	GNA12	oncoprotein	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
10	GNA13	interactor	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
11	L1CAM	oncoprotein	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein Bravo_FIGEY (PF13882, IPR026966): Bravo-like intracellular region Ig_3 (PF13927): Immunoglobulin domain
12	LUC7L2	interactor	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
13	MAPK1	oncoprotein	Pkinase (PF00069, IPR000719): Protein kinase domain
14	MAPK3	oncoprotein	Pkinase (PF00069, IPR000719): Protein kinase domain
15	MRPL23	interactor	Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
16	MRPL49	interactor	Img2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
17	MRPL58	interactor	RF-1 (PF00472, IPR000352): RF-1 domain
18	NACA2	interactor	NAC (PF01849, IPR002715): NAC domain
19	PDPK1	interactor	Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain
20	PEA15	parental protein	DED (PF01335, IPR001875, SM00031): Death effector domain
21	PLD1	suppressor	PH (PF00169, IPR001849, SM00233): PH domain PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif PX (PF00787, IPR001683, SM00312): PX domain PLDc_2 (PF13091, IPR025202): PLD-like domain
22	PLD2	interactor	PH (PF00169, IPR001849, SM00233): PH domain PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif PX (PF00787, IPR001683, SM00312): PX domain PLDc_2 (PF13091, IPR025202): PLD-like domain
23	PPT2	interactor	Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
24	RPL21	interactor	Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
25	RPL3	interactor	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
26	RPL32	interactor	Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
27	RPS16	interactor	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
28	RPS26	interactor	Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
29	RPS6KA3	interactor	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
30	STIL	oncoprotein	STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
31	TERF2IP	interactor	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain

B a c k t o T o p ⇑

Fusion ID: Protein names:	T06950
Level of PPIs:	or Upload text file:	Update repository

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors