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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)198
The number (and %) of the onco-proteins76 (38.38 %)
The number (and %) of the tumor suppressors42 (21.21 %)
Total number of binary PPIs (saturation %)1175 (6.02 %)
The number (and %) of affected PPIs197 (16.77 %)
The number of possible different fusions41
PPI diameter2
PPI radius1
The average degree of PPI10.970
Assortativity coefficient-0.2773
The network average Clustering coefficient0.523
The number (and %) of a zero Clustering coefficients9 (4.55 %)
The number (and %) of a zero Betweenness Centrality32 (16.16 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MAPK1 All fusions
: M84489;
Proteins found in more fusions VDR (see 2 fusions); GAB2 (see 3 fusions); RPS6KA2 (see 1 fusions); GSK3B (see 1 fusions); CUL7 (see 2 fusions); HSF1 (see 3 fusions); MAP3K1 (see 1 fusions); MYC (see 1 fusions); TNFRSF1A (see 2 fusions); SREBF2 (see 2 fusions); NUP153 (see 2 fusions); RARA (see 4 fusions); PDE4D (see 2 fusions); RXRA (see 2 fusions); EP300 (see 1 fusions); DAPK1 (see 1 fusions); CCND1 (see 1 fusions); TP53 (see 3 fusions); RARA/PML (see 21 fusions); VCP (see 4 fusions); SFPQ (see 6 fusions); MAPKAPK5 (see 4 fusions); HDAC4 (see 1 fusions); SQSTM1 (see 5 fusions); LCK (see 1 fusions); MAPK14 (see 1 fusions); SP1 (see 1 fusions); CREBBP (see 6 fusions); STAT3 (see 2 fusions); MCM2 (see 1 fusions); BRAF (see 3 fusions); UBR5 (see 4 fusions); FOS (see 4 fusions); SHC1 (see 1 fusions); NTRK1/TPR (see 1 fusions); PML (see 4 fusions); RPTOR (see 3 fusions); PRKCE (see 3 fusions); SMAD3 (see 3 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 M84489chimera1970.04627234.673Pkinase (PF00069, IPR000719): Protein kinase domain
2 ABCE1interactor120.36421.373ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ADAM15interactor40.5001.786CD20 (PF04103, IPR007237): CD20-like family
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
4 ADAM17interactor30.6671.000Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
Reprolysin_5 (PF13688): Metallo-peptidase family M12
ADAM17_MPD (PF16698, IPR032029): Membrane-proximal domain, switch, for ADAM17
5 AGTR1suppressor40.8330.4007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 ALKoncoprotein70.33311.119MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
7 ARoncoprotein260.38084.034Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
8 ARHGAP9oncoprotein30.6670.667PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
WW (PF00397, IPR001202, SM00456): WW domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
9 ARHGEF2oncoprotein70.4298.048IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
10 ARRB1interactor150.33345.258Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11 ARRB2interactor200.27487.873Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
12 ATF2oncoprotein200.32766.366bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
13 ATP1A1interactor50.5001.060Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
14 BANPsuppressor110.46711.547DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
15 BARD1suppressor90.5716.871BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
16 BCL2oncoprotein150.38534.256Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
17 BRAFoncoprotein80.7623.119Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
18 BRCA1suppressor420.244367.675BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
19 C1QBPinteractor140.36329.526MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
20 CACYBPinteractor40.6670.667CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
21 CAPN2interactor40.5001.400Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
22 CASP8suppressor110.31122.434DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
23 CASP9oncoprotein70.4296.146CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
24 CCND1oncoprotein170.41728.556Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
25 CDC25Concoprotein60.6671.869M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
26 CEBPBoncoprotein170.57522.222RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
27 CENPEinteractor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
VIT1 (PF01988, IPR008217): VIT family
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_13 (PF13166, IPR026866): AAA domain
DUF4023 (PF13215, IPR025097): Protein of unknown function (DUF4023)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
28 CEP350interactor40.6670.417CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
Complex1_LYR_2 (PF13233): Complex1_LYR-like
AAA_23 (PF13476): AAA domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
29 CHEK1suppressor80.5367.200Pkinase (PF00069, IPR000719): Protein kinase domain
30 CHEK2suppressor140.42328.197FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
31 CIITAoncoprotein60.6000.977NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
32 CITED2suppressor41.0000CITED (PF04487, IPR007576): CITED
33 COPS6interactor90.42910.136DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
34 CREBBPsuppressor410.281305.211Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
35 CRPinteractor21.0000Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
36 CTSDinteractor21.0000A1_Propeptide (PF07966, IPR012848): A1 Propeptide
Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
37 CUEDC2interactor40.6670.533CUE (PF02845, IPR003892, SM00546): CUE domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
38 CUL7protein found in more fusions250.145138.745ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
39 DAPK1suppressor60.5003.667ABC_tran (PF00005, IPR003439): ABC transporter
Death (PF00531, IPR000488, SM00005): Death domain
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
40 DCCsuppressor50.4002.533fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
41 DCUN1D1interactor100.35620.800Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
42 DGCR8interactor21.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
WW (PF00397, IPR001202, SM00456): WW domain
43 DNAAF5interactor60.4677.067HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
44 DUSP1suppressor40.6671.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
45 DUSP16interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
46 DUSP3interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
47 DUSP6suppressor31.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
48 DYRK1Boncoprotein80.3816.917Pkinase (PF00069, IPR000719): Protein kinase domain
49 ECT2suppressor50.6002.233BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
50 ELK1oncoprotein50.8330.100Ets (PF00178, IPR000418, SM00413): Ets-domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
51 ELK4oncoprotein31.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
52 ENAHoncoprotein50.4003.310MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
53 EP300oncoprotein540.185739.149Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
54 ESR1suppressor430.204434.939Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
55 ESR2suppressor90.6436.030zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
56 ETS1oncoprotein110.8551.418Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
57 FERMT2interactor50.7000.629FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
58 FGF5oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
59 FHL2oncoprotein180.39055.079LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
60 FOSoncoprotein150.50520.997bZIP_1 (PF00170, IPR004827): bZIP transcription factor
61 FOXO3suppressor100.7785.238Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
62 GAB2oncoprotein50.6670.429PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
63 GADD45Asuppressor100.36114.158Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
64 GAPDHoncoprotein170.29242.757Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
65 GATA4suppressor40.6671.000Apidaecin (PF00807, IPR004828): Apidaecin
GATA-N (PF05349, IPR008013): GATA-type transcription activator, N-terminal
DUF2387 (PF09526, IPR012658): Probable metal-binding protein (DUF2387)
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
66 GNPTABinteractor100DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
Notch (PF00066, IPR000800, SM00004): LNR domain
Stealth_CR2 (PF11380, IPR021520): Stealth protein CR2, conserved region 2
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
Stealth_CR1 (PF17101, IPR031358): Stealth protein CR1, conserved region 1
Stealth_CR3 (PF17102, IPR031357): Stealth protein CR3, conserved region 3
Stealth_CR4 (PF17103, IPR031356): Stealth protein CR4, conserved region 4
67 GSK3Bsuppressor300.200196.066Pkinase (PF00069, IPR000719): Protein kinase domain
68 GSTP1suppressor70.5332.477GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
69 GTF2Iinteractor80.5366.770GTF2I (PF02946, IPR004212): GTF2I-like repeat
70 HDAC4oncoprotein190.30748.714Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
71 HDAC6oncoprotein130.34819.391Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
72 HIF1Asuppressor220.39470.844Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
73 HIST1H2ABinteractor50.8000.350Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
74 HIST1H4Ainteractor70.5712.859CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
75 HMGB1oncoprotein60.5332.214HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
76 HMMRinteractor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
77 HNF4Asuppressor120.7273.933zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
78 HNRNPRinteractor90.4449.872RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
79 HSF1protein found in more fusions60.5003.900DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
80 HSF4interactor21.0000Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
81 ICKinteractor50.6002.083Pkinase (PF00069, IPR000719): Protein kinase domain
82 ID2oncoprotein60.5002.733HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
83 IER3suppressor60.4004.952FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
84 IFI35interactor100IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
85 ILKAPinteractor80.39310.976PP2C (PF00481, IPR001932): Protein phosphatase 2C
86 INSRinteractor80.4299.840fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
87 IQGAP1interactor160.35848.075CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
88 ITGB6interactor21.0000EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
89 ITPK1interactor50.5002.100Ins134_P3_kin (PF05770, IPR008656): Inositol 1, 3, 4-trisphosphate 5/6-kinase
90 JUNoncoprotein330.327182.154bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
91 JUNDoncoprotein70.8570.589bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
92 KARSinteractor80.5367.314tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
93 KLF11interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
94 KRASoncoprotein110.31123.100Ras (PF00071, IPR001806, SM00173): Ras family
95 KRT8interactor50.6002.071Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
96 LCKoncoprotein110.26725.002Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
97 LMNB2interactor60.6001.424Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
98 MAP2K1oncoprotein170.35047.092Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
99 MAP2K2interactor80.8571.186Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
100 MAP2K4suppressor110.48914.900Pkinase (PF00069, IPR000719): Protein kinase domain
101 MAP2K6interactor60.4676.333Pkinase (PF00069, IPR000719): Protein kinase domain
102 MAP2K7interactor90.5289.933Pkinase (PF00069, IPR000719): Protein kinase domain
103 MAP3K1oncoprotein200.27581.402zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
104 MAP3K10interactor41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
105 MAPK12oncoprotein50.4004.167Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
106 MAPK14oncoprotein370.130448.461Pkinase (PF00069, IPR000719): Protein kinase domain
107 MAPK3oncoprotein790.0782335.962Pkinase (PF00069, IPR000719): Protein kinase domain
108 MAPKAPK2oncoprotein110.31120.549Pkinase (PF00069, IPR000719): Protein kinase domain
109 MAPKAPK5protein found in more fusions50.8330.333Pkinase (PF00069, IPR000719): Protein kinase domain
110 MBPinteractor70.4297.456Myelin_MBP (PF01669, IPR000548): Myelin basic protein
111 MCM2oncoprotein230.24299.604AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
112 MKNK1interactor50.6002.500Pkinase (PF00069, IPR000719): Protein kinase domain
113 MKNK2interactor30.6670.400ABC_trans_aux (PF03886, IPR005586): ABC-type transport auxiliary lipoprotein component
Pkinase (PF00069, IPR000719): Protein kinase domain
114 MTIF3interactor100IF3_C (PF00707, IPR019815): Translation initiation factor IF-3, C-terminal domain
IF3_N (PF05198, IPR019814): Translation initiation factor IF-3, N-terminal domain
115 MYConcoprotein320.318174.306HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
116 NAV1oncoprotein100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
AAA_16 (PF13191): AAA ATPase domain
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
117 NCOA3oncoprotein210.41451.452DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
118 NEBoncoprotein40.6670.686Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
DUF3417 (PF11897, IPR024517): Protein of unknown function (DUF3417)
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
NFRKB_winged (PF14465, IPR025220): NFRKB Winged Helix-like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
119 NEK2interactor70.5332.898Pkinase (PF00069, IPR000719): Protein kinase domain
120 NOTCH1suppressor90.39310.918Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
121 NOXA1interactor21.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
122 NTRK1oncoprotein460.103677.771I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
123 NUP153protein found in more fusions100.5288.460Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
124 OTUB1interactor80.4648.568Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
125 PARK2suppressor170.22558.133IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
126 PAX5suppressor21.0000PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
127 PDCD6IPinteractor40.6671.000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
128 PDE4Doncoprotein50.8330.250Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
129 PEBP1suppressor40.6671.333PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
130 PECAM1oncoprotein31.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
131 PGRsuppressor120.47315.477Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
132 PLA2G4Aoncoprotein30.6670.222C2 (PF00168, IPR000008, SM00239): C2 domain
PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
133 PMLsuppressor260.293125.338zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
134 PPARGsuppressor190.38646.422zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
135 PPP1CConcoprotein140.30837.164Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
136 PPP2R5Binteractor30.6670.400B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
137 PPP2R5Csuppressor70.5245.300B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
138 PRKCEsuppressor60.6003.333C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
139 PRPSAP1interactor200Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
140 PTGDRsuppressor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
141 PTPN5interactor30.6670.250Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
142 PTPREoncoprotein21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
143 PTPRFinteractor70.4298.525Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST)
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
144 PTPRRinteractor40.6670.495Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3149 (PF11346, IPR021494): Protein of unknown function (DUF3149)
145 PXNoncoprotein60.3338.333LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
146 RABGEF1interactor40.6670.125Rho_Binding (PF08912, IPR015008): Rho Binding
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
SSTK-IP (PF15836, IPR031679): SSTK-interacting protein, TSSK6-activating co-chaperone protein
147 RAF1oncoprotein200.28184.456Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
148 RARAoncoprotein120.45515.667zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
149 RESToncoprotein31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Presenilin (PF01080, IPR001108): Presenilin
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
150 REToncoprotein70.5332.937Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
151 RPS6KA1oncoprotein140.38531.736Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
152 RPS6KA2suppressor70.8001.056Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
153 RPS6KA3interactor80.6072.900Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
154 RPS6KA4interactor40.6670.556Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
155 RPS6KA5interactor60.7331.833Choline_kinase (PF01633): Choline/ethanolamine kinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
156 RPTORprotein found in more fusions100.4179.073HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
157 RXRAoncoprotein130.5309.730zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
158 RYKoncoprotein40.6671.167Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
159 SFPQoncoprotein150.33031.515GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
160 SHANK3interactor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
161 SHC1oncoprotein120.32723.675PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
162 SMAD1interactor120.58212.372MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
163 SMAD3oncoprotein370.316230.894MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
164 SORBS3interactor31.0000Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
165 SP1protein found in more fusions330.339167.178zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
166 SQSTM1oncoprotein220.26297.798PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
167 SREBF1interactor110.6227.065HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
168 SREBF2protein found in more fusions100.7223.448HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
169 STAB2interactor31.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Fasciclin (PF02469, IPR000782, SM00554): Fasciclin domain
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
170 STAT3suppressor240.277115.428SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
171 STAT5Asuppressor120.40021.712SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
172 SUPT20Hinteractor30.6670.333Rubella_E2 (PF05749, IPR008821): Rubella membrane glycoprotein E2
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Spt20 (PF12090, IPR021950): Spt20 family
UL73_N (PF12522, IPR021003): Cytomegalovirus glycoprotein N terminal
173 SYNE2oncoprotein50.6001.404ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
SlyX (PF04102, IPR007236): SlyX
Spectrin (PF00435, IPR002017): Spectrin repeat
TMPIT (PF07851, IPR012926): TMPIT-like protein
KASH (PF10541, IPR012315): Nuclear envelope localisation domain
HD_5 (PF13487): HD domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
174 TFCP2interactor30.6670.500CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
175 THinteractor21.0000Biopterin_H (PF00351, IPR019774): Biopterin-dependent aromatic amino acid hydroxylase
TOH_N (PF12549, IPR021164): Tyrosine hydroxylase N terminal
176 TIAL1interactor60.4674.487RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
177 TNFRSF1Aoncoprotein50.5002.667Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
178 TNFRSF25interactor200Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
179 TNIP1interactor40.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
180 TNIP2interactor40.5002.500PCRF (PF03462, IPR005139, SM00937): PCRF domain
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
zf-C2H2_4 (PF13894): C2H2-type zinc finger
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
181 TNKS2interactor200Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
182 TOB1interactor50.5002.233PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
BTG (PF07742, IPR002087, SM00099): BTG family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
183 TOP2Aoncoprotein80.7142.201DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Toprim (PF01751, IPR006171, SM00493): Toprim domain
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
184 TP53suppressor520.190674.308DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
185 TP53BP1suppressor120.48519.49053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
186 TPRoncoprotein70.4765.325Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
187 TSC2suppressor80.5006.590Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
Tuberin (PF03542, IPR018515): Tuberin
DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
188 TTNinteractor80.3936.819DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
189 UBR5protein found in more fusions120.40019.079CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
190 UBTFinteractor70.3814.400Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
191 VAV1oncoprotein60.4005.286PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
192 VCPprotein found in more fusions280.242158.245AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
193 VDRsuppressor170.58317.270zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
194 WDR83interactor70.6674.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
195 XPO6interactor60.4676.167IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
196 YBX1oncoprotein160.37534.062CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
197 YBX3interactor70.4764.388CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
198 ZC3HC1interactor30.6670.667Rsm1 (PF08600, IPR013909): Rsm1-like
zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATP6V1DinteractorATP-synt_D (PF01813, IPR002699): ATP synthase subunit D
2 CAV1suppressorCaveolin (PF01146, IPR001612): Caveolin
3 EGLN3suppressor2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
4 EIF4EBP1oncoproteineIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
5 GORASP2interactorGRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
6 LAMTOR3interactorMAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
7 MAPK1parental proteinPkinase (PF00069, IPR000719): Protein kinase domain
8 MINOS1interactorDUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
9 MTPNinteractorAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
10 NTMT1interactorMethyltransf_PK (PF05891, IPR008576): AdoMet dependent proline di-methyltransferase
11 PEA15suppressorDED (PF01335, IPR001875, SM00031): Death effector domain
12 PFKMinteractorPFK (PF00365, IPR000023): Phosphofructokinase
13 PTPN7oncoproteinY_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
14 RRM2interactorRibonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
15 SNCAinteractorSynuclein (PF01387, IPR001058): Synuclein
16 SNCGoncoproteinSynuclein (PF01387, IPR001058): Synuclein
17 VDAC1interactorPorin_3 (PF01459, IPR027246): Eukaryotic porin

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