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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: L37033 is the fusion of parental proteins FKBP8 (from a repository: Mon Dec 5 22:00:36 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)87
The number (and %) of the onco-proteins22 (25.29 %)
The number (and %) of the tumor suppressors4 (4.60 %)
Total number of binary PPIs (saturation %)690 (18.44 %)
The number (and %) of affected PPIs86 (12.46 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI15.149
Assortativity coefficient-0.1077
The network average Clustering coefficient0.702
The number (and %) of a zero Clustering coefficients4 (4.60 %)
The number (and %) of a zero Betweenness Centrality19 (21.84 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FKBP8 All fusions
: L37033;
Proteins found in more fusions PSMC2 (see 1 fusions); ABCC1 (see 1 fusions); HSP90AA1 (see 2 fusions); CUL3 (see 1 fusions); PSMB3 (see 1 fusions); VHL (see 1 fusions); PSMB7 (see 2 fusions); BCL2L1 (see 1 fusions); EGFR (see 2 fusions); PSMA7 (see 2 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); RPTOR (see 3 fusions); PSMC5 (see 2 fusions); EGLN1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 L37033chimera860.1574998.408FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
2 ABCB7interactor30.6670.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
3 ABCC1oncoprotein60.6003.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class
DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
4 ADRB2interactor90.3939.8557tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 ADRM1interactor310.9357.353Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
6 ARHGEF5interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
ARHGEF5_35 (PF15441, IPR029212): Rho guanine nucleotide exchange factor 5/35
7 ATP13A2interactor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
MARVEL (PF01284, IPR008253): Membrane-associating domain
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
8 ATP6AP2interactor60.4005.333Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
9 BCL2oncoprotein50.6672.000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
10 BCL2L1oncoprotein50.6672.000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
11 BNIPLinteractor41.0000BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
12 BREoncoprotein21.0000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
13 CACYBPinteractor50.8330.667CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
14 CALM1interactor80.6073.428EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
15 CAMK2Ainteractor40.6670.286CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
16 CCDC8interactor100.47212.268Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
17 CDK20oncoprotein51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
18 CLN3interactor21.0000CLN3 (PF02487, IPR003492): CLN3 protein
19 COQ9interactor60.5004.333COQ9 (PF08511, IPR013718): COQ9
20 CUL3protein found in more fusions160.50537.186Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
21 DHODHinteractor100DHO_dh (PF01180, IPR012135): Dihydroorotate dehydrogenase
FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
PASTA (PF03793, IPR005543, SM00740): PASTA domain
22 EGFRoncoprotein170.30865.534Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23 EGLN1suppressor31.0000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
24 EVC2interactor40.5003.000HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
25 HSP90AA1oncoprotein190.20395.892HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
26 HSPBP1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like
HEAT_EZ (PF13513): HEAT-like repeat
27 KCNH2interactor21.0000Ion_trans (PF00520, IPR005821): Ion transport protein
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
PAS_9 (PF13426, IPR000014): PAS domain
28 MLH1suppressor40.8330.080DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
29 MLST8interactor41.0000Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
30 MRPL11interactor30.6671.000Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
31 MRPL15interactor21.0000Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
32 MTORoncoprotein90.39315.833DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
33 NDUFB10interactor100NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
34 NNTinteractor30.6670.667AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
35 PDCLinteractor30.6671.000Phosducin (PF02114, IPR024253): Phosducin
36 PGRMC1interactor50.4003.800Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
SlyX (PF04102, IPR007236): SlyX
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
37 PSMA1interactor330.87728.872Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
38 PSMA2interactor320.92913.772Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
39 PSMA3interactor320.92911.271Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
40 PSMA4interactor291.0000Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
41 PSMA5oncoprotein310.9424.729Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
42 PSMA6interactor300.9860.472Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
43 PSMA7protein found in more fusions340.84726.362Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
44 PSMB1interactor320.88122.596Proteasome (PF00227, IPR001353): Proteasome subunit
45 PSMB2interactor310.93110.872Proteasome (PF00227, IPR001353): Proteasome subunit
46 PSMB3protein found in more fusions310.9438.390Proteasome (PF00227, IPR001353): Proteasome subunit
47 PSMB5interactor330.83336.637Proteasome (PF00227, IPR001353): Proteasome subunit
48 PSMB7protein found in more fusions310.9860.472Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
49 PSMC1interactor340.80242.367AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
50 PSMC2protein found in more fusions330.89115.296AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
51 PSMC3interactor330.88319.696AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
52 PSMC4interactor310.9424.729AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
53 PSMC5protein found in more fusions360.746105.748AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
54 PSMC6interactor320.93110.872AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
55 PSMD1interactor350.77046.713PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
56 PSMD11interactor310.92527.472DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
57 PSMD12interactor320.92913.525Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
58 PSMD13interactor300.9438.390Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
59 PSMD14interactor300.9860.472JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
60 PSMD2oncoprotein350.72476.728PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
61 PSMD3interactor320.84332.286Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
62 PSMD4interactor310.9357.353UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
63 PSMD6interactor300.93814.333RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
64 PSMD7interactor300.9860.472JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
65 PTGES3interactor70.5336.333CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
66 PTPRKsuppressor40.5001.917fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
67 RHEBoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
68 RICTORinteractor41.0000RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
69 RPS6KB2interactor90.47212.819Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
70 RPTORprotein found in more fusions60.8001.333HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
71 SSR1interactor60.3337.300TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
72 SUGT1interactor80.46411.400CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
73 SURF1interactor40.6672.000SURF1 (PF02104, IPR002994): SURF1 family
74 TCTN2interactor40.5002.333DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
75 TCTN3interactor40.5002.333DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
76 TERF1interactor70.6004.019TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
77 TMEM216interactor50.4005.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
78 TOMM22interactor50.6003.667Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
79 UBCprotein found in more fusions350.547157.707ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
80 UQCRC1interactor60.4007.452Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
81 UQCRC2oncoprotein130.25644.990Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
82 UQCRFS1interactor21.0000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
83 USP19interactor40.6671.222CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
84 VAPAinteractor80.35715.333DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
85 VHLsuppressor100.47211.682Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
86 XRCC3oncoprotein21.0000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
87 YME1L1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FKBP8parental proteinFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat

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