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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: L13387 is the fusion of parental proteins PRKCA, PAFAH1B1 (from a repository: Thu Feb 2 06:20:49 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)161
The number (and %) of the onco-proteins49 (30.43 %)
The number (and %) of the tumor suppressors23 (14.29 %)
Total number of binary PPIs (saturation %)674 (5.23 %)
The number (and %) of affected PPIs160 (23.74 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI7.590
Assortativity coefficient-0.2580
The network average Clustering coefficient0.539
The number (and %) of a zero Clustering coefficients20 (12.42 %)
The number (and %) of a zero Betweenness Centrality50 (31.06 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PRKCA,PAFAH1B1 All fusions
: L13387;
Proteins found in more fusions LMNA (see 3 fusions); YWHAG (see 1 fusions); HSP90AA1 (see 2 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); WWC2 (see 1 fusions); CSNK2A1/ELAVL1 (see 1 fusions); SLC9A3R1 (see 2 fusions); SACM1L (see 1 fusions); DSP (see 4 fusions); YWHAH (see 2 fusions); NF2 (see 1 fusions); DLG4 (see 1 fusions); KIF11 (see 1 fusions); NDEL1 (see 1 fusions); EZR (see 2 fusions); YWHAZ (see 1 fusions); PDE4D (see 2 fusions); EGFR (see 2 fusions); RACK1 (see 3 fusions); CSNK2A1 (see 1 fusions); IKBKB (see 2 fusions); NDE1 (see 3 fusions); EP300 (see 1 fusions); PAK2 (see 2 fusions); MTOR (see 1 fusions); SDC2 (see 2 fusions); IBTK (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 L13387chimera1600.03521146.550C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2 ACIN1interactor50.9000.250Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
3 AFAP1interactor40.6670.286PH (PF00169, IPR001849, SM00233): PH domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Enkurin (PF13864, IPR027012): Calmodulin-binding
4 AKAP12suppressor31.0000OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein
RII_binding_1 (PF10522, IPR018459): RII binding domain
WSK (PF03832, IPR001573): WSK motif
5 AKAP13oncoprotein21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
6 AKAP5interactor30.6671.000WSK (PF03832, IPR001573): WSK motif
7 ANXA6interactor30.6670.133Annexin (PF00191, IPR018502, SM00335): Annexin
8 ATP1A1interactor60.5332.708Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 AVPR1Ainteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF1856 (PF08983, IPR015076, SM01164): Domain of unknown function (DUF1856)
DUF5134 (PF17197): Domain of unknown function (DUF5134)
10 AVPR1Binteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF1856 (PF08983, IPR015076, SM01164): Domain of unknown function (DUF1856)
11 BTG2suppressor21.0000BTG (PF07742, IPR002087, SM00099): BTG family
12 C1QBPinteractor60.5334.952MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
13 CACYBPinteractor50.8330.154CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
14 CAPN2interactor50.4004.619Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
15 CAPNS1interactor70.6195.400EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
16 CASRinteractor2007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
DUF2614 (PF11023, IPR020912): Zinc-ribbon containing domain
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
17 CBLsuppressor90.7143.717Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
18 CCDC8interactor180.20667.594Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
19 CCNL2interactor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
20 CD53oncoprotein21.0000Tetraspannin (PF00335, IPR018499): Tetraspanin family
21 CD9oncoprotein40.6672.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
22 CDK2suppressor250.221153.108Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
23 CDKN2Asuppressor80.5007.158Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
24 CEP128interactor110.34528.217DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
25 CEP135interactor70.5248.167DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPD52 (PF04201, IPR007327): Tumour protein D52 family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
26 CHUKsuppressor120.47315.494Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
27 CLIP1oncoprotein60.5333.252ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
CP12 (PF02672, IPR003823, SM01093): CP12 domain
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
SlyX (PF04102, IPR007236): SlyX
ApoO (PF09769, IPR019166): Apolipoprotein O
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Leu_zip (PF15294): Leucine zipper
CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
28 CSNK2A1oncoprotein170.30855.597Pkinase (PF00069, IPR000719): Protein kinase domain
29 CTNNB1oncoprotein290.241201.387Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
30 CYP3A4interactor200p450 (PF00067, IPR001128): Cytochrome P450
31 DCTN1interactor110.35619.173Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
32 DDX58suppressor60.5004.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
AAA_22 (PF13401, IPR003593): AAA domain
Syntaxin_2 (PF14523): Syntaxin-like protein
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
33 DISC1interactor70.5245.167HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
34 DLG4protein found in more fusions40.6670.667L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
35 DSPsuppressor70.4005.756APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CLP_protease (PF00574, IPR023562): Clp protease
DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fez1 (PF06818): Fez1
FIVAR (PF07554, IPR011490): Uncharacterised Sugar-binding Domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Rho_Binding (PF08912, IPR015008): Rho Binding
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
SOGA (PF11365, IPR027881): Protein SOGA
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
36 DYNC1H1interactor140.34141.260AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
37 DYNC1I1interactor50.6003.000CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
38 EGFRoncoprotein220.243123.464Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
39 EIF2S1interactor60.8000.819EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
40 EIF4EBP1oncoprotein31.0000eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
41 ELAVL1oncoprotein270.222188.360RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
42 EP300oncoprotein210.237113.532Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
43 EZRprotein found in more fusions140.38536.227DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
44 FASsuppressor51.0000Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
45 FBXO25suppressor50.7001.133Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
46 FSCN1oncoprotein40.8330.286Fascin (PF06268, IPR022768): Fascin domain
47 GABRB3interactor21.0000Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
48 GJA1suppressor40.6670.667Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
49 GLI3oncoprotein21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
50 GRIN1interactor30.6671.000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
CaM_bdg_C0 (PF10562, IPR018882): Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
51 GRIN2Binteractor40.5002.667ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
NMDAR2_C (PF10565, IPR018884): N-methyl D-aspartate receptor 2B3 C-terminus
52 GRM5interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
53 GRM7interactor21.00007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
54 GSK3Ainteractor70.3817.823Pkinase (PF00069, IPR000719): Protein kinase domain
55 GSK3Bsuppressor140.33339.294Pkinase (PF00069, IPR000719): Protein kinase domain
56 HABP4interactor30.6670.500HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
57 HAND1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
58 HAND2interactor41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
59 HDAC6oncoprotein180.39044.214Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
60 HIST1H1Ainteractor50.8000.686Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
61 HIST1H1Boncoprotein50.8000.508Pneumo_att_G (PF05539, IPR008781): Pneumovirinae attachment membrane glycoprotein G
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
62 HIST1H1Concoprotein50.7000.844Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
63 HIST1H1Dinteractor41.0000Stm1_N (PF09598, IPR019084): Stm1
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
64 HIST1H1Einteractor30.6670.500Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
65 HIST1H1Tinteractor100Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
66 HIST1H3Ainteractor160.25757.221Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
67 HIST3H3interactor60.6003.905Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
68 HMGA1oncoprotein70.5245.633AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
69 HMGA2oncoprotein31.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1639 (PF07797, IPR012438): Protein of unknown function (DUF1639)
70 HMGB3interactor70.3337.992HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
71 HMGN1interactor50.6672.000HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
72 HMGN2interactor41.0000HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
73 HSP90AA1oncoprotein300.185254.704HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
74 HSP90AA4Pinteractor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
75 IBTKprotein found in more fusions50.6672.000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
76 IKBKBprotein found in more fusions100.47211.090FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
77 ISG15suppressor120.40922.706ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 ITGB1suppressor70.5715.252EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
79 ITGB2interactor40.6670.917EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
80 JSRP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
81 KARSinteractor31.0000tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
82 KATNA1interactor40.8330.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
83 KIF11protein found in more fusions90.5006.691Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
84 KIF2Ainteractor50.6671.500Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
85 KLF5suppressor60.7331.900zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
86 LMNAprotein found in more fusions110.48910.389Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
87 LMNB1interactor60.6003.033Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
88 LNX1interactor70.4008.167PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
89 LNX2interactor60.5004.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
90 MAPK7oncoprotein100.44415.456Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
91 MAPKAP1interactor31.0000SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain
SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
92 MBPinteractor21.0000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
93 MGMTinteractor70.6193.027DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
94 MOV10interactor180.20374.572AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
95 MSNoncoprotein120.40024.019DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
96 MTORoncoprotein150.27550.908DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
97 MYO1Einteractor50.5002.125IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
98 NCF1interactor40.6671.000p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
99 NDE1protein found in more fusions80.5246.458NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
100 NDEL1protein found in more fusions120.32729.852HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
101 NF2suppressor90.35714.192ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
102 NFE2L2oncoprotein30.6670.667bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
103 NFKBIAoncoprotein41.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
104 NOXA1interactor30.6671.000PB1 (PF00564, IPR000270, SM00666): PB1 domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
105 NPM1suppressor260.240161.702Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
106 NR1H2oncoprotein100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
107 NTRK1oncoprotein470.144695.046I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
108 NUDCinteractor60.6002.973CS (PF04969, IPR007052): CS domain
D5_N (PF08706, IPR014818, SM00885): D5 N terminal like
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
NuDC (PF16273, IPR032572): Nuclear distribution C domain
109 NUMBsuppressor50.5003.833NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
110 NXF1interactor250.156169.153NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
111 OGG1interactor100HhH-GPD (PF00730, IPR003265): HhH-GPD superfamily base excision DNA repair protein
OGG_N (PF07934, IPR012904): 8-oxoguanine DNA glycosylase, N-terminal domain
112 PAK2protein found in more fusions90.7143.167PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
113 PDE4Doncoprotein50.6671.167Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
114 PFKFB1interactor2006PF2K (PF01591, IPR013079): 6-phosphofructo-2-kinase
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
115 PICK1oncoprotein21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
116 PLA2G4Aoncoprotein40.6670.792C2 (PF00168, IPR000008, SM00239): C2 domain
PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
117 PLCG2interactor40.5002.500C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
118 PLD1suppressor30.6671.000PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
119 PLD2interactor31.0000PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
120 PPARGsuppressor110.31120.683zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
121 PPP1R14Ainteractor21.0000PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
122 PSMB4interactor100Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
123 PTGIRinteractor40.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
124 RACK1suppressor150.25352.102WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
125 RALBP1interactor50.4004.833DDHD (PF02862, IPR004177, SM01127): DDHD domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SlyX (PF04102, IPR007236): SlyX
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
126 RBCK1interactor50.6671.333GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
127 RGS2oncoprotein21.0000RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
128 RICTORinteractor90.44411.419RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
129 RNF31interactor50.6671.667Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
PUB (PF09409, IPR018997): PUB domain
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
130 RRADinteractor30.6670.286Ras (PF00071, IPR001806, SM00173): Ras family
AAA_16 (PF13191): AAA ATPase domain
131 SACM1Lprotein found in more fusions31.0000DSS1_SEM1 (PF05160, IPR007834): DSS1/SEM1 family
Syja_N (PF02383, IPR002013): SacI homology domain
132 SCRIBsuppressor60.5332.073Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SDA1 (PF05285, IPR007949): SDA1
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
133 SDC2protein found in more fusions41.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
134 SELLinteractor31.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
135 SLC1A1interactor100SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
136 SLC25A11interactor40.6670.400Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
137 SLC25A41interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
138 SLC9A3R1suppressor90.5715.536EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
139 SLC9A3R2interactor21.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
140 SPAG1interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
TPR_19 (PF14559): Tetratricopeptide repeat
141 STXBP1interactor30.6670.667Sec1 (PF00995, IPR001619): Sec1 family
142 TAS2R7interactor100TAS2R (PF05296, IPR007960): Taste receptor protein (TAS2R)
143 TBXA2Rinteractor50.5002.2507tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
144 TIAM1oncoprotein21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
AAA_22 (PF13401, IPR003593): AAA domain
145 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
146 TNP1interactor30.6670.500TP1 (PF02079, IPR001319): Nuclear transition protein 1
147 TNP2interactor100TP2 (PF01254, IPR000678): Nuclear transition protein 2
148 TOP2Aoncoprotein70.6193.450DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Toprim (PF01751, IPR006171, SM00493): Toprim domain
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
149 TRIM41interactor40.6670.667BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
150 TRPV6oncoprotein100Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
151 TUBA1Aoncoprotein130.39729.340Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
152 UBXN1interactor70.5335.833Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
153 UQCRBinteractor100UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
154 VPS4Binteractor50.5002.936AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
155 VTNinteractor30.6671.000Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
156 WWC1interactor90.36118.092APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
157 WWC2protein found in more fusions41.0000DASH_Dad2 (PF08654, IPR013963): DASH complex subunit Dad2
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Phage_Nu1 (PF07471, IPR010906): Phage DNA packaging protein Nu1
WW (PF00397, IPR001202, SM00456): WW domain
158 WWC3interactor41.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
IncA (PF04156, IPR007285): IncA protein
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain
DUF4452 (PF14618, IPR027915): Domain of unknown function (DUF4452)
LURAP (PF14854): Leucine rich adaptor protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
159 YWHAGprotein found in more fusions200.25794.08514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
160 YWHAHprotein found in more fusions170.34253.71014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
161 YWHAZprotein found in more fusions280.234195.30614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AP1G1interactorAdaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
2 ASNSoncoproteinAsn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
3 ATIConcoproteinAICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
4 BICD2interactorBicD (PF09730, IPR018477): Microtubule-associated protein Bicaudal-D
5 CHID1interactorFe_hyd_lg_C (PF02906, IPR004108): Iron only hydrogenase large subunit, C-terminal domain
Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
6 CHMP2BinteractorInvolucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
7 CSTF1interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
CSTF1_dimer (PF16699, IPR032028): Cleavage stimulation factor subunit 1, dimerisation domain
8 DCTN2interactorDynamitin (PF04912): Dynamitin
9 DCXinteractorDCX (PF03607, IPR003533, SM00537): Doublecortin
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
10 DYNLL1interactorDynein_light (PF01221, IPR001372): Dynein light chain type 1
11 EIF5interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
12 FHsuppressorLyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
13 IQCB1interactorDUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
14 ISOC1interactorIsochorismatase (PF00857, IPR000868): Isochorismatase family
Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
15 KATNB1interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Katanin_con80 (PF13925, IPR028021): con80 domain of Katanin
16 MAPRE1oncoproteinCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
17 NUDCD2interactorCS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
18 PAFAH1B1parental proteinLisH (PF08513, IPR013720, SM00667): LisH
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
19 PAFAH1B2oncoproteinLipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
20 PAFAH1B3interactorLipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
21 PAPSS1interactorAPS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
PUA_2 (PF14306, IPR025980): PUA-like domain
22 PDE4BinteractorPDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
YlqD (PF11068, IPR021297): YlqD protein
23 PDIA4interactorCalsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
24 PRKCAparental proteinC2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
25 SBDSoncoproteinSBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
26 SCLYinteractorAminotran_5 (PF00266, IPR000192): Aminotransferase class-V
27 SNRPD2interactorLSM (PF01423, IPR001163): LSM domain
28 SNRPFinteractorLSM (PF01423, IPR001163): LSM domain
29 TATDN1interactorTatD_DNase (PF01026, IPR001130): TatD related DNase
30 TNIKinteractorCNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
31 WDR5interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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