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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: L03357 is the fusion of parental proteins PRKAR1A, RET (from a repository: Wed Nov 23 14:50:31 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)112
The number (and %) of the onco-proteins37 (33.04 %)
The number (and %) of the tumor suppressors20 (17.86 %)
Total number of binary PPIs (saturation %)548 (8.82 %)
The number (and %) of affected PPIs111 (20.26 %)
The number of possible different fusions23
PPI diameter2
PPI radius1
The average degree of PPI8.946
Assortativity coefficient-0.2800
The network average Clustering coefficient0.543
The number (and %) of a zero Clustering coefficients12 (10.71 %)
The number (and %) of a zero Betweenness Centrality33 (29.46 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RET,PRKAR1A All fusions
: L03357;
Proteins found in more fusions EGFR/PTPRF (see 1 fusions); ILK (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); MAPT (see 1 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); SETD7 (see 2 fusions); EGFR (see 2 fusions); PJA2 (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); PRPF40A (see 2 fusions); CBS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 L03357chimera1120.0648788.024Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
2 AGO2interactor110.45517.129ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3 AGO3interactor80.6074.265ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 AIPsuppressor41.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
5 AKAP1interactor50.8000.556TUDOR (PF00567, IPR002999, SM00333): Tudor domain
RII_binding_1 (PF10522, IPR018459): RII binding domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
6 AKAP10interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
7 AKAP11interactor90.41710.969E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone
RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
8 AKAP3interactor21.0000AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110)
RII_binding_1 (PF10522, IPR018459): RII binding domain
9 AKAP4interactor21.0000AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110)
RII_binding_1 (PF10522, IPR018459): RII binding domain
10 ANKRD26interactor100DUF1269 (PF06897, IPR009200): Protein of unknown function (DUF1269)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
FlxA (PF14282, IPR025577): FlxA-like protein
CCDC144C (PF14915): CCDC144C protein coiled-coil region
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
11 ARFGEF1interactor40.6671.667DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
12 ARFGEF2interactor30.6670.667DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
13 ARPC3interactor80.42910.319P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
14 BAG6interactor130.33329.781DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
15 BAHD1interactor100BAH (PF01426, IPR001025, SM00439): BAH domain
16 BTRConcoprotein150.33040.789WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
17 C2orf88interactor21.0000SmAKAP (PF15127, IPR027969): Small membrane A-kinase anchor protein
18 CAPN11interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
19 CBLsuppressor150.56021.630Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
20 CBLConcoprotein70.6194.334Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
21 CBSprotein found in more fusions50.8330.250CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
22 CCDC8interactor130.40921.596Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
23 CCNE1oncoprotein60.5332.141Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
24 CDK2suppressor160.26748.027Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
25 CEP250interactor50.6002.067ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
26 CRKoncoprotein150.48624.137SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27 CUL3protein found in more fusions260.230151.314Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
28 CUL7protein found in more fusions190.25573.637ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29 DOK1suppressor90.8211.732IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
30 DOK2suppressor60.8001.083IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
31 DOK4interactor40.8330.250IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
32 DOK5interactor21.0000IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
33 DOK6interactor21.0000IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
34 DYRK1Aoncoprotein80.7142.611DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
35 DYRK1Boncoprotein60.6001.905Pkinase (PF00069, IPR000719): Protein kinase domain
36 EGFRoncoprotein320.254243.509Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37 ELAVL1oncoprotein250.203161.918RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 FRMD5interactor100FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
39 GABARAPL1interactor30.6670.143Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
40 GPR161oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
41 GRB10oncoprotein60.7331.425BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
42 GRB2oncoprotein200.48536.910SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
43 GRB7interactor30.6670.333BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
44 GSK3Bsuppressor170.30051.010Pkinase (PF00069, IPR000719): Protein kinase domain
45 HIVEP1suppressor40.6670.900PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
46 HNRNPDoncoprotein160.32444.336CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
47 HSP90AA1oncoprotein290.254193.145HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
48 HSP90AA4Pinteractor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
49 IFI16suppressor60.3338.333HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
50 IKBKGinteractor130.40921.819CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
51 ILKsuppressor100.44413.495Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
52 KYNUinteractor100Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
53 MAPK1oncoprotein110.31119.726Pkinase (PF00069, IPR000719): Protein kinase domain
54 MAPK3oncoprotein60.5004.067Pkinase (PF00069, IPR000719): Protein kinase domain
55 MAPK6oncoprotein70.4673.717Pkinase (PF00069, IPR000719): Protein kinase domain
56 MAPTprotein found in more fusions100.4178.771Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
57 MCRS1interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
58 MEN1suppressor100Menin (PF05053, IPR007747): Menin
59 MTORoncoprotein120.36420.740DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
60 MYO7Ainteractor100FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
61 NELL2interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
TILa (PF12714, IPR025615): TILa domain
EGF_3 (PF12947, IPR024731): EGF domain
62 NOTCH2NLinteractor21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
63 NOTCH3suppressor40.6670.722Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
64 NPM1suppressor150.39629.359Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
65 NPRL2suppressor30.6670.500NPR2 (PF06218, IPR009348): Nitrogen permease regulator 2
66 NTRK1oncoprotein380.221353.040I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
67 NUAK1suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
68 PALM2-AKAP2interactor21.0000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
69 PATZ1oncoprotein31.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
70 PDLIM7interactor60.5334.467LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
71 PFDN5interactor31.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
72 PJA2protein found in more fusions50.8330.143zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
73 PLCG1oncoprotein110.6916.145C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
74 PLEKHF2interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
75 PPP1CAsuppressor120.45514.433Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
76 PRKACAinteractor210.238126.060Pkinase (PF00069, IPR000719): Protein kinase domain
77 PRKACBinteractor100.5568.960Pkinase (PF00069, IPR000719): Protein kinase domain
78 PRKACGinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
79 PRKAR1Binteractor90.5716.114RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
80 PRKXinteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
81 PRPF31interactor80.5246.595Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
82 PRPF40Aprotein found in more fusions110.42218.706FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
83 PTK2protein found in more fusions170.50831.483FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
84 PTPRFprotein found in more fusions70.5714.487Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST)
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
85 PYCARDsuppressor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
86 RAF1oncoprotein100.52811.475Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87 RFC2interactor50.6002.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_16 (PF13191): AAA ATPase domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
88 SAFBsuppressor60.8000.604RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
89 SEToncoprotein70.6672.733NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
90 SETD7protein found in more fusions40.6671.000MORN (PF02493, IPR003409, SM00698): MORN repeat
MORN_2 (PF07661, IPR011652): MORN repeat variant
SET (PF00856, IPR001214, SM00317): SET domain
91 SGTBinteractor31.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
92 SHC1oncoprotein170.45837.499PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
93 SLC2A4interactor21.0000Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
94 SLC38A5interactor100Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
95 SMAD2suppressor50.5001.300MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
96 SMURF1interactor110.35617.906C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
97 SORT1interactor50.8000.650Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
98 SOX2oncoprotein100.30620.405HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
99 SRConcoprotein180.41937.589Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
100 STAT3suppressor140.39730.815SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
101 STOML2oncoprotein80.6794.682Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
Band_7_C (PF16200, IPR032435): C-terminal region of band_7
102 SYNCRIPinteractor170.38242.965RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
103 TAB1interactor90.5837.798PP2C (PF00481, IPR001932): Protein phosphatase 2C
104 UBCprotein found in more fusions240.269118.994ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
105 UBE2Minteractor80.2868.456UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
106 VAPAinteractor60.6672.675DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
107 WDCPinteractor31.0000DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
108 WNK1interactor50.6671.000SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
109 XPO1interactor350.173370.088CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
110 ZBED1interactor300Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)
111 ZBTB48suppressor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
112 ZCCHC8interactor60.6672.476Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein
PSP (PF04046, IPR006568, SM00581): PSP
zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FRS2interactorIRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
2 GFRA1interactorGDNF (PF02351, IPR016017, SM00907): GDNF/GAS1 domain
3 HIST1H3AinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
4 ICE2interactorNARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
5 NRTNinteractorTGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
6 PRKAR1Aparental proteinRIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
7 RETparental proteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
8 TXNL4AinteractorDIM1 (PF02966, IPR004123): Mitosis protein DIM1

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