Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	112
The number (and %) of the onco-proteins	37 (33.04 %)
The number (and %) of the tumor suppressors	20 (17.86 %)
Total number of binary PPIs (saturation %)	548 (8.82 %)
The number (and %) of affected PPIs	111 (20.26 %)
The number of possible different fusions	23
PPI diameter	2
PPI radius	1
The average degree of PPI	8.946
Assortativity coefficient	-0.2800
The network average Clustering coefficient	0.543
The number (and %) of a zero Clustering coefficients	12 (10.71 %)
The number (and %) of a zero Betweenness Centrality	33 (29.46 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RET,PRKAR1A	All fusions : L03357;
Proteins found in more fusions	EGFR/PTPRF (see 1 fusions); ILK (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); MAPT (see 1 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); SETD7 (see 2 fusions); EGFR (see 2 fusions); PJA2 (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); PRPF40A (see 2 fusions); CBS (see 1 fusions);

List of the fusions

PPI for parental proteins: RET,PRKAR1A

All fusions

: L03357;

Proteins found in more fusions

EGFR/PTPRF (see 1 fusions); ILK (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); MAPT (see 1 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); SETD7 (see 2 fusions); EGFR (see 2 fusions); PJA2 (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); PRPF40A (see 2 fusions); CBS (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	L03357	chimera	112	0.064	8788.024	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
2	AGO2	interactor	11	0.455	17.129	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3	AGO3	interactor	8	0.607	4.265	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4	AIP	suppressor	4	1.000	0	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
5	AKAP1	interactor	5	0.800	0.556	TUDOR (PF00567, IPR002999, SM00333): Tudor domain RII_binding_1 (PF10522, IPR018459): RII binding domain KH_1 (PF00013, IPR004088, SM00322): KH domain
6	AKAP10	interactor	1	0	0	RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
7	AKAP11	interactor	9	0.417	10.969	E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
8	AKAP3	interactor	2	1.000	0	AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110) RII_binding_1 (PF10522, IPR018459): RII binding domain
9	AKAP4	interactor	2	1.000	0	AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110) RII_binding_1 (PF10522, IPR018459): RII binding domain
10	ANKRD26	interactor	1	0	0	DUF1269 (PF06897, IPR009200): Protein of unknown function (DUF1269) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) FlxA (PF14282, IPR025577): FlxA-like protein CCDC144C (PF14915): CCDC144C protein coiled-coil region PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
11	ARFGEF1	interactor	4	0.667	1.667	DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
12	ARFGEF2	interactor	3	0.667	0.667	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
13	ARPC3	interactor	8	0.429	10.319	P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
14	BAG6	interactor	13	0.333	29.781	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
15	BAHD1	interactor	1	0	0	BAH (PF01426, IPR001025, SM00439): BAH domain
16	BTRC	oncoprotein	15	0.330	40.789	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
17	C2orf88	interactor	2	1.000	0	SmAKAP (PF15127, IPR027969): Small membrane A-kinase anchor protein
18	CAPN11	interactor	1	0	0	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
19	CBL	suppressor	15	0.560	21.630	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
20	CBLC	oncoprotein	7	0.619	4.334	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
21	CBS	protein found in more fusions	5	0.833	0.250	CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
22	CCDC8	interactor	13	0.409	21.596	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
23	CCNE1	oncoprotein	6	0.533	2.141	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
24	CDK2	suppressor	16	0.267	48.027	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
25	CEP250	interactor	5	0.600	2.067	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
26	CRK	oncoprotein	15	0.486	24.137	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27	CUL3	protein found in more fusions	26	0.230	151.314	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
28	CUL7	protein found in more fusions	19	0.255	73.637	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29	DOK1	suppressor	9	0.821	1.732	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
30	DOK2	suppressor	6	0.800	1.083	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
31	DOK4	interactor	4	0.833	0.250	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
32	DOK5	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
33	DOK6	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
34	DYRK1A	oncoprotein	8	0.714	2.611	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
35	DYRK1B	oncoprotein	6	0.600	1.905	Pkinase (PF00069, IPR000719): Protein kinase domain
36	EGFR	oncoprotein	32	0.254	243.509	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37	ELAVL1	oncoprotein	25	0.203	161.918	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38	FRMD5	interactor	1	0	0	FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
39	GABARAPL1	interactor	3	0.667	0.143	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
40	GPR161	oncoprotein	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
41	GRB10	oncoprotein	6	0.733	1.425	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
42	GRB2	oncoprotein	20	0.485	36.910	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
43	GRB7	interactor	3	0.667	0.333	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
44	GSK3B	suppressor	17	0.300	51.010	Pkinase (PF00069, IPR000719): Protein kinase domain
45	HIVEP1	suppressor	4	0.667	0.900	PHD (PF00628, IPR019787, SM00249): PHD-finger PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_7 (PF15269): Zinc-finger
46	HNRNPD	oncoprotein	16	0.324	44.336	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
47	HSP90AA1	oncoprotein	29	0.254	193.145	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
48	HSP90AA4P	interactor	1	0	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
49	IFI16	suppressor	6	0.333	8.333	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
50	IKBKG	interactor	13	0.409	21.819	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
51	ILK	suppressor	10	0.444	13.495	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
52	KYNU	interactor	1	0	0	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
53	MAPK1	oncoprotein	11	0.311	19.726	Pkinase (PF00069, IPR000719): Protein kinase domain
54	MAPK3	oncoprotein	6	0.500	4.067	Pkinase (PF00069, IPR000719): Protein kinase domain
55	MAPK6	oncoprotein	7	0.467	3.717	Pkinase (PF00069, IPR000719): Protein kinase domain
56	MAPT	protein found in more fusions	10	0.417	8.771	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
57	MCRS1	interactor	2	1.000	0	FHA (PF00498, IPR000253, SM00240): FHA domain MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
58	MEN1	suppressor	1	0	0	Menin (PF05053, IPR007747): Menin
59	MTOR	oncoprotein	12	0.364	20.740	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
60	MYO7A	interactor	1	0	0	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain
61	NELL2	interactor	1	0	0	EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like TILa (PF12714, IPR025615): TILa domain EGF_3 (PF12947, IPR024731): EGF domain
62	NOTCH2NL	interactor	2	1.000	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
63	NOTCH3	suppressor	4	0.667	0.722	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
64	NPM1	suppressor	15	0.396	29.359	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
65	NPRL2	suppressor	3	0.667	0.500	NPR2 (PF06218, IPR009348): Nitrogen permease regulator 2
66	NTRK1	oncoprotein	38	0.221	353.040	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
67	NUAK1	suppressor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
68	PALM2-AKAP2	interactor	2	1.000	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
69	PATZ1	oncoprotein	3	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
70	PDLIM7	interactor	6	0.533	4.467	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
71	PFDN5	interactor	3	1.000	0	Prefoldin (PF02996, IPR004127): Prefoldin subunit UPF0693 (PF16088, IPR032143): UPF0693 family
72	PJA2	protein found in more fusions	5	0.833	0.143	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
73	PLCG1	oncoprotein	11	0.691	6.145	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
74	PLEKHF2	interactor	2	1.000	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger PH (PF00169, IPR001849, SM00233): PH domain
75	PPP1CA	suppressor	12	0.455	14.433	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
76	PRKACA	interactor	21	0.238	126.060	Pkinase (PF00069, IPR000719): Protein kinase domain
77	PRKACB	interactor	10	0.556	8.960	Pkinase (PF00069, IPR000719): Protein kinase domain
78	PRKACG	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
79	PRKAR1B	interactor	9	0.571	6.114	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
80	PRKX	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
81	PRPF31	interactor	8	0.524	6.595	Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
82	PRPF40A	protein found in more fusions	11	0.422	18.706	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
83	PTK2	protein found in more fusions	17	0.508	31.483	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
84	PTPRF	protein found in more fusions	7	0.571	4.487	Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
85	PYCARD	suppressor	3	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
86	RAF1	oncoprotein	10	0.528	11.475	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87	RFC2	interactor	5	0.600	2.500	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_16 (PF13191): AAA ATPase domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
88	SAFB	suppressor	6	0.800	0.604	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
89	SET	oncoprotein	7	0.667	2.733	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
90	SETD7	protein found in more fusions	4	0.667	1.000	MORN (PF02493, IPR003409, SM00698): MORN repeat MORN_2 (PF07661, IPR011652): MORN repeat variant SET (PF00856, IPR001214, SM00317): SET domain
91	SGTB	interactor	3	1.000	0	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_11 (PF13414, IPR011990): TPR repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
92	SHC1	oncoprotein	17	0.458	37.499	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
93	SLC2A4	interactor	2	1.000	0	Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
94	SLC38A5	interactor	1	0	0	Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
95	SMAD2	suppressor	5	0.500	1.300	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
96	SMURF1	interactor	11	0.356	17.906	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
97	SORT1	interactor	5	0.800	0.650	Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
98	SOX2	oncoprotein	10	0.306	20.405	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
99	SRC	oncoprotein	18	0.419	37.589	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
100	STAT3	suppressor	14	0.397	30.815	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
101	STOML2	oncoprotein	8	0.679	4.682	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769) Band_7_C (PF16200, IPR032435): C-terminal region of band_7
102	SYNCRIP	interactor	17	0.382	42.965	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
103	TAB1	interactor	9	0.583	7.798	PP2C (PF00481, IPR001932): Protein phosphatase 2C
104	UBC	protein found in more fusions	24	0.269	118.994	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
105	UBE2M	interactor	8	0.286	8.456	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
106	VAPA	interactor	6	0.667	2.675	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
107	WDCP	interactor	3	1.000	0	DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
108	WNK1	interactor	5	0.667	1.000	SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
109	XPO1	interactor	35	0.173	370.088	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
110	ZBED1	interactor	3	0	0	Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region zf-BED (PF02892, IPR003656, SM00614): BED zinc finger DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)
111	ZBTB48	suppressor	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
112	ZCCHC8	interactor	6	0.667	2.476	Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein PSP (PF04046, IPR006568, SM00581): PSP zf-CCHC (PF00098, IPR001878): Zinc knuckle DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	FRS2	interactor	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
2	GFRA1	interactor	GDNF (PF02351, IPR016017, SM00907): GDNF/GAS1 domain
3	HIST1H3A	interactor	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
4	ICE2	interactor	NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
5	NRTN	interactor	TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
6	PRKAR1A	parental protein	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
7	RET	parental protein	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
8	TXNL4A	interactor	DIM1 (PF02966, IPR004123): Mitosis protein DIM1

B a c k t o T o p ⇑

Fusion ID: Protein names:	L03357
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List of the fusions

List of active interactors

List of missing interactors