Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	75
The number (and %) of the onco-proteins	39 (52.00 %)
The number (and %) of the tumor suppressors	5 (6.67 %)
Total number of binary PPIs (saturation %)	272 (9.80 %)
The number (and %) of affected PPIs	74 (27.21 %)
The number of possible different fusions	16
PPI diameter	2
PPI radius	1
The average degree of PPI	6.453
Assortativity coefficient	-0.2680
The network average Clustering coefficient	0.585
The number (and %) of a zero Clustering coefficients	10 (13.33 %)
The number (and %) of a zero Betweenness Centrality	29 (38.67 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CUX1,RET	All fusions : KF421948;
Proteins found in more fusions	EGFR/PTPRF (see 1 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); KAT2B (see 1 fusions); FOXO1 (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); GAN (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); FOXP1 (see 3 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); GRB2 (see 1 fusions);

List of the fusions

PPI for parental proteins: CUX1,RET

All fusions

: KF421948;

Proteins found in more fusions

EGFR/PTPRF (see 1 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); KAT2B (see 1 fusions); FOXO1 (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); GAN (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); FOXP1 (see 3 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); GRB2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KF421948	chimera	74	0.062	4353.491	Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein DegS (PF05384, IPR008595): Sensor protein DegS DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region ApoO (PF09769, IPR019166): Apolipoprotein O DUF4618 (PF15397, IPR029236): Domain of unknown function (DUF4618)
2	AIP	suppressor	4	1.000	0	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
3	BAG6	interactor	8	0.429	10.733	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
4	BIN1	oncoprotein	3	1.000	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
5	CBL	oncoprotein	12	0.727	7.551	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
6	CBLC	oncoprotein	6	0.667	4.182	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
7	CCNA1	interactor	5	0.600	1.533	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
8	CDK1	oncoprotein	12	0.309	30.533	Pkinase (PF00069, IPR000719): Protein kinase domain
9	CDK7	oncoprotein	5	0.667	1.667	Pkinase (PF00069, IPR000719): Protein kinase domain
10	CREBBP	oncoprotein	10	0.361	19.400	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
11	CRK	oncoprotein	11	0.618	13.120	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12	DOK1	suppressor	9	0.821	1.732	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
13	DOK2	suppressor	6	0.800	1.083	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
14	DOK4	interactor	3	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
15	DOK5	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
16	DOK6	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
17	ECT2	oncoprotein	2	1.000	0	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
18	EGFR	oncoprotein	23	0.333	114.358	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
19	EHMT2	interactor	5	0.667	2.000	CDC45 (PF02724, IPR003874): CDC45-like protein Pre-SET (PF05033, IPR007728): Pre-SET motif Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family SET (PF00856, IPR001214, SM00317): SET domain SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
20	ELAC2	oncoprotein	2	1.000	0	Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
21	FOXD3	suppressor	2	1.000	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N (PF10399, IPR019470): Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
22	FOXG1	oncoprotein	2	1.000	0	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SPX (PF03105, IPR004331): SPX domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
23	FOXJ2	interactor	2	1.000	0	SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Forkhead (PF00250, IPR001766, SM00339): Forkhead domain Spt20 (PF12090, IPR021950): Spt20 family Pro-rich (PF15240, IPR026086): Proline-rich
24	FOXK2	interactor	6	0.333	9.000	FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
25	FOXO1	oncoprotein	5	0.500	1.833	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
26	FOXP1	oncoprotein	3	1.000	0	Auxin_repressed (PF05564, IPR008406): Dormancy/auxin associated protein DOPA_dioxygen (PF08883, IPR014980): Dopa 4,5-dioxygenase family Forkhead (PF00250, IPR001766, SM00339): Forkhead domain DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298) FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
27	GABRE	interactor	1	0	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
28	GAN	protein found in more fusions	3	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
29	GRB10	oncoprotein	3	1.000	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
30	GRB2	oncoprotein	16	0.514	32.725	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
31	GRB7	interactor	2	1.000	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
32	HIST1H3A	interactor	8	0.381	11.333	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33	HLA-DQA1	interactor	3	0.667	0.667	MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
34	HNRNPD	oncoprotein	8	0.476	8.833	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
35	HSP90AA1	oncoprotein	15	0.418	41.448	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
36	IKBKG	interactor	8	0.571	7.167	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
37	KAT2B	protein found in more fusions	12	0.255	37.233	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
38	KCND3	interactor	3	0.667	0.333	Ion_trans (PF00520, IPR005821): Ion transport protein BTB_2 (PF02214, IPR003131): BTB/POZ domain Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal DUF3399 (PF11879, IPR024587): Domain of unknown function (DUF3399)
39	KYNU	interactor	1	0	0	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
40	MAGEA10	interactor	3	0.667	1.000	MAGE (PF01454, IPR002190): MAGE family SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
41	MAPK1	oncoprotein	11	0.356	23.917	Pkinase (PF00069, IPR000719): Protein kinase domain
42	MAPK3	oncoprotein	7	0.600	4.333	Pkinase (PF00069, IPR000719): Protein kinase domain
43	MAX	oncoprotein	4	0.667	1.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SlyX (PF04102, IPR007236): SlyX
44	MCRS1	interactor	2	1.000	0	FHA (PF00498, IPR000253, SM00240): FHA domain MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
45	NFATC1	oncoprotein	3	1.000	0	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
46	NIT1	interactor	2	0	0	CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
47	NOTCH2NL	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
48	NOTCH3	oncoprotein	4	0.667	2.000	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
49	NTRK1	oncoprotein	23	0.299	129.151	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
50	PDLIM7	interactor	3	0.667	1.000	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
51	PLCG1	oncoprotein	10	0.778	4.253	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
52	PTH1R	interactor	1	0	0	7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family) HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
53	PTK2	protein found in more fusions	16	0.486	40.153	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
54	PTPRF	protein found in more fusions	4	0.833	0.400	Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
55	RB1	oncoprotein	10	0.311	23.283	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
56	RBPJ	interactor	5	0.600	3.667	BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding TIG (PF01833, IPR002909): IPT/TIG domain
57	RECQL5	oncoprotein	2	1.000	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5) SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding TAtT (PF16811, IPR031823): TRAP transporter T-component
58	SATB1	oncoprotein	7	0.333	13.500	CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
59	SGTB	interactor	2	1.000	0	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_11 (PF13414, IPR011990): TPR repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
60	SHC1	oncoprotein	14	0.577	15.576	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
61	SLC39A4	tumor suppressor	1	0	0	Zip (PF02535, IPR003689): ZIP Zinc transporter Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
62	SORT1	interactor	4	0.833	0.667	Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
63	SOX2	oncoprotein	6	0.400	5.167	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
64	SPATS2L	interactor	1	0	0	DUF1296 (PF06972, IPR009719): Protein of unknown function (DUF1296) DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
65	SRC	oncoprotein	18	0.412	52.026	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
66	STAT3	oncoprotein	12	0.527	13.617	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
67	STX6	interactor	1	0	0	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal SNARE (PF05739, IPR000727, SM00397): SNARE domain
68	SUMO2	interactor	3	1.000	0	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
69	SYNCRIP	interactor	6	0.733	2.500	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
70	TACC3	oncoprotein	3	0.667	0.500	TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
71	TLE4	interactor	1	0	0	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4662 (PF15578, IPR028970): Domain of unknown function (DUF4662)
72	TP53BP1	oncoprotein	7	0.333	12.500	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
73	WDR83	interactor	5	0.600	3.167	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
74	ZBTB48	oncoprotein	2	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
75	ZCCHC8	interactor	3	0.667	0.667	Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein PSP (PF04046, IPR006568, SM00581): PSP zf-CCHC (PF00098, IPR001878): Zinc knuckle DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	CUX1	parental protein	Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein CUT (PF02376, IPR003350, SM01109): CUT domain DegS (PF05384, IPR008595): Sensor protein DegS DivIC (PF04977, IPR007060): Septum formation initiator DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Swi5 (PF07061, IPR010760): Swi5 TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein ApoO (PF09769, IPR019166): Apolipoprotein O Homeobox (PF00046, IPR001356, SM00389): Homeobox domain RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
2	FOXE1	interactor	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
3	FOXN1	interactor	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
4	FOXQ1	interactor	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
5	FRS2	interactor	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
6	GFRA1	interactor	GDNF (PF02351, IPR016017, SM00907): GDNF/GAS1 domain
7	ICE2	interactor	NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
8	NRTN	interactor	TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
9	RET	parental protein	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
10	TXNL4A	interactor	DIM1 (PF02966, IPR004123): Mitosis protein DIM1

B a c k t o T o p ⇑

Fusion ID: Protein names:	KF421948
Level of PPIs:	or Upload text file:	Update repository

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors