Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	89
The number (and %) of the onco-proteins	25 (28.09 %)
The number (and %) of the tumor suppressors	14 (15.73 %)
Total number of binary PPIs (saturation %)	944 (24.11 %)
The number (and %) of affected PPIs	88 (9.32 %)
The number of possible different fusions	19
PPI diameter	2
PPI radius	1
The average degree of PPI	20.472
Assortativity coefficient	-0.1161
The network average Clustering coefficient	0.610
The number (and %) of a zero Clustering coefficients	5 (5.62 %)
The number (and %) of a zero Betweenness Centrality	11 (12.36 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HPCAL4,MED1	All fusions : H21133;
Proteins found in more fusions	NTRK1/HNRNPC (see 1 fusions); VDR (see 2 fusions); NR3C1 (see 8 fusions); NCOA6 (see 1 fusions); MYC (see 1 fusions); BAG3 (see 4 fusions); POLR2E (see 2 fusions); SETD7 (see 2 fusions); RARA (see 4 fusions); POLR2A (see 2 fusions); RXRA (see 2 fusions); QKI (see 3 fusions); HNRNPC (see 1 fusions); EPAS1 (see 1 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); THRA (see 3 fusions); TP53 (see 3 fusions);

List of the fusions

PPI for parental proteins: HPCAL4,MED1

All fusions

: H21133;

Proteins found in more fusions

NTRK1/HNRNPC (see 1 fusions); VDR (see 2 fusions); NR3C1 (see 8 fusions); NCOA6 (see 1 fusions); MYC (see 1 fusions); BAG3 (see 4 fusions); POLR2E (see 2 fusions); SETD7 (see 2 fusions); RARA (see 4 fusions); POLR2A (see 2 fusions); RXRA (see 2 fusions); QKI (see 3 fusions); HNRNPC (see 1 fusions); EPAS1 (see 1 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); THRA (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	H21133	chimera	88	0.215	3122.911	Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
2	AR	oncoprotein	11	0.422	13.608	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3	ATM	suppressor	7	0.467	3.021	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4	BAG3	oncoprotein	3	1.000	0	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
5	BRD4	oncoprotein	6	0.733	0.856	Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
6	CCNC	suppressor	29	0.823	9.268	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
7	CDK19	interactor	28	0.881	5.218	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain
8	CTDP1	interactor	17	0.779	4.408	Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme FCP1_C (PF09309, IPR015388): FCP1, C-terminal NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A PTCB-BRCT (PF12738, IPR001357): twin BRCT domain HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
9	EMC2	interactor	6	0.933	0.200	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_19 (PF14559): Tetratricopeptide repeat Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
10	EPAS1	suppressor	21	0.942	1.068	Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 PAS_11 (PF14598): PAS domain
11	ESR1	suppressor	35	0.390	169.548	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
12	ESR2	suppressor	19	0.725	11.905	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
13	EZH2	suppressor	9	0.429	9.075	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
14	FBXL16	interactor	1	0	0	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
15	FBXW7	suppressor	31	0.618	70.919	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
16	GABPA	interactor	1	0	0	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain GABP-alpha (PF11620, IPR024668): GA-binding protein alpha chain Wap1 (PF16997, IPR031550): Wap1 domain
17	GATA1	oncoprotein	3	1.000	0	GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
18	GATA2	oncoprotein	4	0.500	1.917	GATA (PF00320, IPR000679, SM00401): GATA zinc finger
19	GJB5	interactor	1	0	0	Connexin (PF00029, IPR013092, SM00037): Connexin
20	HNF4A	suppressor	19	0.490	32.773	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
21	HNRNPC	protein found in more fusions	8	0.571	3.521	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
22	KAT2A	interactor	15	0.538	20.345	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
23	KIF1A	interactor	6	0.400	3.709	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B Sox_N (PF12444, IPR022151): Sox developmental protein N terminal DUF3694 (PF12473, IPR022164): Kinesin protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
24	MDM2	oncoprotein	15	0.363	27.730	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
25	MED10	interactor	40	0.638	52.965	Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
26	MED11	interactor	25	0.897	3.551	Med11 (PF10280, IPR019404): Mediator complex protein
27	MED12	oncoprotein	48	0.507	147.653	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
28	MED13	oncoprotein	36	0.657	40.302	Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
29	MED13L	interactor	16	0.967	0.309	Totivirus_coat (PF05518, IPR008871): Totivirus coat protein Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
30	MED14	interactor	48	0.470	187.717	Med14 (PF08638, IPR013947): Mediator complex subunit MED14
31	MED15	interactor	38	0.633	55.718	Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
32	MED16	interactor	49	0.476	202.514	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Med16 (PF11635, IPR021665): Mediator complex subunit 16
33	MED17	oncoprotein	52	0.457	230.876	Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
34	MED18	interactor	29	0.862	6.508	Med18 (PF09637, IPR019095): Med18 protein
35	MED20	interactor	33	0.756	20.505	Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
36	MED22	interactor	24	0.801	11.042	Med22 (PF06179, IPR009332): Surfeit locus protein 5 subunit 22 of Mediator complex
37	MED23	interactor	47	0.537	112.161	Med23 (PF11573, IPR021629): Mediator complex subunit 23
38	MED24	interactor	48	0.487	185.367	Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
39	MED25	interactor	33	0.571	68.330	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1 Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
40	MED26	interactor	39	0.656	46.082	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
41	MED27	interactor	34	0.772	16.398	Med27 (PF11571, IPR021627): Mediator complex subunit 27
42	MED28	interactor	37	0.722	27.174	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
43	MED29	interactor	40	0.677	40.113	Med29 (PF11568, IPR021018): Mediator complex subunit 29
44	MED30	interactor	31	0.784	14.002	Med30 (PF11315, IPR021019): Mediator complex subunit 30
45	MED31	interactor	17	0.801	3.078	Med31 (PF05669, IPR008831): SOH1
46	MED4	interactor	43	0.605	81.661	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
47	MED6	interactor	39	0.630	68.051	Med6 (PF04934, IPR007018): MED6 mediator sub complex component Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
48	MED7	interactor	36	0.673	37.583	Med7 (PF05983, IPR009244): MED7 protein DotU (PF09850, IPR017732): Type VI secretion system protein DotU
49	MED8	interactor	33	0.752	24.014	Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
50	MED9	interactor	35	0.713	27.876	Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
51	MYC	oncoprotein	18	0.360	45.310	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
52	NCOA6	oncoprotein	18	0.324	44.704	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
53	NR1H2	oncoprotein	5	0.900	0.333	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
54	NR1I3	interactor	13	0.641	11.322	PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
55	NR3C1	protein found in more fusions	11	0.489	9.391	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
56	NTRK1	oncoprotein	18	0.375	47.116	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
57	OBFC1	interactor	17	0.897	1.501	STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1 RUN (PF02759, IPR004012, SM00593): RUN domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
58	PARP1	suppressor	17	0.433	37.371	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
59	PIN1	suppressor	9	0.361	11.510	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
60	POLL	interactor	1	0	0	HHH (PF00633, IPR000445): Helix-hairpin-helix motif DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda HHH_5 (PF14520): Helix-hairpin-helix domain HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
61	POLR2A	protein found in more fusions	29	0.368	124.431	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
62	POLR2E	protein found in more fusions	13	0.773	3.633	RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
63	POLR2F	interactor	13	0.769	2.670	RNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
64	POLR2G	interactor	21	0.742	8.085	SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
65	POU1F1	interactor	6	0.467	4.986	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Lsr2 (PF11774, IPR024412): Lsr2
66	PPARG	suppressor	16	0.343	35.214	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
67	PPARGC1A	interactor	17	0.507	22.047	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
68	PPP4R3A	interactor	3	1.000	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1 WH1 (PF00568, IPR000697, SM00461): WH1 domain DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
69	QKI	protein found in more fusions	20	0.743	12.533	KH_1 (PF00013, IPR004088, SM00322): KH domain STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
70	RALY	interactor	7	0.571	5.325	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
71	RARA	oncoprotein	12	0.364	17.948	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
72	RXRA	oncoprotein	15	0.418	25.205	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
73	SETD7	protein found in more fusions	6	0.900	0.250	MORN (PF02493, IPR003409, SM00698): MORN repeat MORN_2 (PF07661, IPR011652): MORN repeat variant SET (PF00856, IPR001214, SM00317): SET domain
74	SREBF1	interactor	19	0.647	24.311	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
75	SUPT3H	interactor	11	0.782	2.977	TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
76	SUPT7L	interactor	7	0.952	0.154	Bromo_TP (PF07524, IPR006565): Bromodomain associated
77	TADA2A	interactor	30	0.524	83.820	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
78	TCL1B	oncoprotein	15	0.943	0.526	TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
79	TGS1	interactor	3	1.000	0	DinI (PF06183, IPR010391): DinI-like family DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Methyltransf_15 (PF09445, IPR019012): RNA cap guanine-N2 methyltransferase Presenilin (PF01080, IPR001108): Presenilin
80	THRA	suppressor	10	0.667	3.028	C1_2 (PF03107, IPR004146): C1 domain zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
81	THRAP3	oncoprotein	9	0.444	7.624	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
82	TP53	suppressor	23	0.320	83.394	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
83	TRIP4	interactor	21	0.590	26.599	ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
84	TRRAP	interactor	19	0.614	22.875	BALF1 (PF06861, IPR010677): BALF1 protein BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) CLASP_N (PF12348, IPR024395): CLASP N terminal Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ (PF13513): HEAT-like repeat TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain ACDC (PF14733, IPR028078): AP2-coincident C-terminal
85	TTC12	interactor	1	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
86	VDR	suppressor	22	0.400	57.723	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
87	ZC3H13	interactor	23	0.909	2.531	FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
88	ZNF281	oncoprotein	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger GRP (PF07172, IPR010800): Glycine rich protein family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 zf-C2H2_4 (PF13894): C2H2-type zinc finger
89	ZNF326	interactor	2	1.000	0	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) DUF678 (PF05077, IPR007769): Protein of unknown function (DUF678) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	CDK8	interactor	Pkinase (PF00069, IPR000719): Protein kinase domain
2	CDK9	interactor	Pkinase (PF00069, IPR000719): Protein kinase domain
3	CYP1A1	oncoprotein	p450 (PF00067, IPR001128): Cytochrome P450
4	DGUOK	interactor	dNK (PF01712, IPR002624): Deoxynucleoside kinase
5	DNAAF2	interactor	Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57 PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
6	DTX2	oncoprotein	WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
7	ELAVL1	oncoprotein	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8	FAM131C	interactor	FAM131 (PF15010, IPR026782): Putative cell signalling
9	HPCAL4	parental protein	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
10	MED1	parental protein	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
11	MED19	interactor	Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
12	MED21	interactor	Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
13	NUFIP1	interactor	NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395) zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
14	TRA	oncoprotein	NA
15	TSC22D3	interactor	TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
16	UBE3A	oncoprotein	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
17	YWHAQ	interactor	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

Fusion ID: Protein names:	H21133
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

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