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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: H05577 is the fusion of parental proteins CLCN3, SMNDC1 (from a repository: Thu Dec 8 06:39:22 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins6 (46.15 %)
The number (and %) of the tumor suppressors2 (15.38 %)
Total number of binary PPIs (saturation %)30 (38.46 %)
The number (and %) of affected PPIs12 (40.00 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.692
Assortativity coefficient-0.2529
The network average Clustering coefficient0.609
The number (and %) of a zero Clustering coefficients2 (15.38 %)
The number (and %) of a zero Betweenness Centrality6 (46.15 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CLCN3,SMNDC1 All fusions
: H05577;
Proteins found in more fusions HSPB1 (see 4 fusions); GOPC (see 2 fusions); CUL3 (see 1 fusions); LGALS3 (see 2 fusions); SLC9A3R1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 H05577chimera120.18292.000CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
2 CFTRsuppressor70.4009.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
3 CUL3protein found in more fusions50.6672.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
4 GOPConcoprotein40.6671.000DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
5 HSPB1oncoprotein50.6672.000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
6 LGALS3oncoprotein40.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
7 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
8 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
9 LYPD3oncoprotein100DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
10 MOV10interactor30.6671.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
11 PDZK1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
12 SF3B3interactor31.0000CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
13 SLC9A3R1suppressor41.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CDK5RAP3interactorDUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
2 CLCN3parental proteinCBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
3 DDX21interactorCRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
4 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 EWSR1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
6 FDFT1interactorSQS_PSY (PF00494, IPR002060): Squalene/phytoene synthase
7 HIST3H3interactorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
8 KIF23interactorDUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
9 LDHDinteractorFAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
10 MRM3interactorSpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
11 NFATC2IPinteractorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
12 PPANinteractorBrix (PF04427, IPR007109, SM00879): Brix domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
13 PRPF3interactorDUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
PRP3 (PF08572, IPR013881): pre-mRNA processing factor 3 (PRP3)
PWI (PF01480, IPR002483, SM00311): PWI domain
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
14 RACGAP1interactorRhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
15 RBM42interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 RPL3interactorRibosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
17 RRBP1interactorFez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Pentapeptide_2 (PF01469, IPR002989): Pentapeptide repeats (8 copies)
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
RTBV_P46 (PF06216, IPR009347): Rice tungro bacilliform virus P46 protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
UPF0767 (PF15990, IPR031933): UPF0767 family
18 RUVBL1oncoproteinTIP49 (PF06068, IPR010339): TIP49 C-terminus
19 SF3A2interactorCytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
20 SF3A3interactorDUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
21 SF3B1oncoproteinDopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
22 SF3B2interactorDUF382 (PF04037, IPR007180): Domain of unknown function (DUF382)
PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
PSP (PF04046, IPR006568, SM00581): PSP
SAP (PF02037, IPR003034, SM00513): SAP domain
Usp (PF00582, IPR006016): Universal stress protein family
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
23 SF3B4interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 SF3B5interactorSF3b10 (PF07189, IPR009846): Splicing factor 3B subunit 10 (SF3b10)
25 SMNDC1parental proteinSMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
26 SND1interactorTUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
27 SNRNP200interactorDEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
28 TSR1interactorAARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein

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