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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: FM165194 is the fusion of parental proteins KMT2A, ACTN4 (from a repository: Mon Dec 5 07:34:50 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)126
The number (and %) of the onco-proteins53 (42.06 %)
The number (and %) of the tumor suppressors22 (17.46 %)
Total number of binary PPIs (saturation %)917 (11.64 %)
The number (and %) of affected PPIs125 (13.63 %)
The number of possible different fusions31
PPI diameter2
PPI radius1
The average degree of PPI13.667
Assortativity coefficient-0.2542
The network average Clustering coefficient0.489
The number (and %) of a zero Clustering coefficients6 (4.76 %)
The number (and %) of a zero Betweenness Centrality16 (12.70 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ACTN4,KMT2A All fusions
: FM165194;
Proteins found in more fusions AFF1 (see 2 fusions); CTBP1 (see 2 fusions); VDR (see 2 fusions); HDAC7 (see 1 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); SMARCB1 (see 12 fusions); RUNX1 (see 1 fusions); CREBBP (see 6 fusions); CREBBP/KAT6A (see 10 fusions); EWSR1 (see 2 fusions); FMNL1 (see 1 fusions); MAPRE1 (see 1 fusions); KIF11 (see 1 fusions); KAT8 (see 1 fusions); RARA (see 4 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); POLR2A (see 2 fusions); CHD3 (see 1 fusions); SHC1 (see 1 fusions); HDAC5 (see 1 fusions); SMARCC1 (see 2 fusions); HCFC1 (see 2 fusions); MAP3K5 (see 1 fusions); STAT1 (see 1 fusions); NCL (see 3 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FM165194chimera1250.0959142.971FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DZR (PF12773, IPR025874): Double zinc ribbon
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
2 AFDNoncoprotein60.4003.667DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FHA (PF00498, IPR000253, SM00240): FHA domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Pap_E4 (PF02711, IPR003861): E4 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
ARGLU (PF15346): Arginine and glutamate-rich 1
3 AFF1oncoprotein110.6009.136AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4 AFF4oncoprotein90.6945.419AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
5 ASB2interactor80.4298.852Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
6 ASH2Linteractor180.43432.113SPRY (PF00622, IPR003877, SM00449): SPRY domain
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
7 ATXN7interactor31.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
8 AVPinteractor31.0000Protamine_P1 (PF00260, IPR000221): Protamine P1
9 BMI1oncoprotein200.38650.773zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
10 CBFBsuppressor50.6003.667CBF_beta (PF02312, IPR003417): Core binding factor beta subunit
11 CBX4oncoprotein120.38219.271Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
12 CBX8interactor100.6396.452Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
13 CCNT1oncoprotein140.46221.594Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
MDFI (PF15316, IPR026134): MyoD family inhibitor
14 CDC73suppressor150.42933.666CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
15 CDK9protein found in more fusions170.42538.484Pkinase (PF00069, IPR000719): Protein kinase domain
16 CDKN2Asuppressor100.5338.484Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
17 CHD3oncoprotein200.48037.746CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
18 COILinteractor50.6671.167CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
19 CREBBPsuppressor300.328128.556Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
20 CSNK2A2interactor130.37223.891Pkinase (PF00069, IPR000719): Protein kinase domain
21 CTBP1protein found in more fusions170.46722.4402-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
22 CTNNB1oncoprotein190.31066.716Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
23 CTR9interactor150.42939.640DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
24 CUL7protein found in more fusions210.33765.381ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
25 CXXC1interactor100.6007.236ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLATZ (PF04640, IPR006734): PLATZ transcription factor
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347)
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
26 DOT1Loncoprotein90.41714.035AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DivIC (PF04977, IPR007060): Septum formation initiator
DOT1 (PF08123, IPR013110): Histone methylation protein DOT1
ZapB (PF06005, IPR009252): Cell division protein ZapB
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
27 DYNLT1interactor30.6671.000Tctex-1 (PF03645, IPR005334): Tctex-1 family
28 E2F2suppressor21.0000E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
29 E2F4suppressor50.8000.450E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SPX (PF03105, IPR004331): SPX domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
30 E2F6oncoprotein70.7141.950BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
31 EGFRoncoprotein150.39626.824Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
32 ELAVL1oncoprotein380.230315.602RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
33 ELLoncoprotein90.5289.671Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
34 ESR1suppressor360.235259.749Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
35 EWSR1oncoprotein210.40550.464RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
36 FMNL1protein found in more fusions200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
37 GNB2interactor80.6074.402WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
38 H3F3Aoncoprotein140.37431.597Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
39 HCFC1protein found in more fusions220.35767.782fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
40 HCFC2interactor61.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
41 HDAC1suppressor390.316234.968FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
42 HDAC2suppressor340.405105.552Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
43 HDAC5protein found in more fusions230.35168.885Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
44 HDAC7protein found in more fusions90.6433.612Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
45 HECW2interactor120.40021.883C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
46 HGSinteractor40.6672.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
47 HIST1H2BGoncoprotein70.3816.386Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
48 HIST1H3Ainteractor270.280129.426Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
49 HIST1H4Ainteractor150.41927.315CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
50 HIST2H3Cinteractor100.26720.269Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
51 HIST3H3interactor330.242218.457Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
52 HUWE1oncoprotein200.33950.172BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
53 ING4suppressor70.4002.950PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
54 INO80interactor21.0000Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DBINO (PF13892, IPR020838): DNA-binding domain
FAM176 (PF14851): FAM176 family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
55 INSinteractor100Insulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
56 ISG15suppressor80.4296.831ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57 KAT6Aoncoprotein120.40916.769BUD22 (PF09073, IPR015158): BUD22
MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
zf-met (PF12874): Zinc-finger of C2H2 type
58 KAT8protein found in more fusions120.40016.139MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
59 KIF11protein found in more fusions70.5332.106Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
60 KPNA2interactor110.43610.489Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
61 KRASoncoprotein100.33316.215Ras (PF00071, IPR001806, SM00173): Ras family
62 LEO1interactor100.6895.456Leo1 (PF04004, IPR007149): Leo1-like protein
PPP4R2 (PF09184, IPR015267): PPP4R2
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
63 LGR4interactor50.5001.8337tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
64 LUZP4interactor50.5002.200Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
65 MAGI1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_C58 (PF03543, IPR006473): Yersinia/Haemophilus virulence surface antigen
Serglycin (PF04360, IPR007455): Serglycin
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
PDZ_2 (PF13180, IPR001478): PDZ domain
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
DUF4770 (PF15994, IPR031935): Domain of unknown function (DUF4770)
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
66 MAP3K5oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
67 MAPK7oncoprotein60.5002.778Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
68 MAPRE1oncoprotein60.6002.583CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
69 MBD3interactor150.58219.099DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
70 MCM2oncoprotein220.23386.004AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
71 MEF2Aoncoprotein80.5716.619TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
72 MEN1suppressor230.36079.421Menin (PF05053, IPR007747): Menin
73 MLLT1oncoprotein150.44833.288DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
74 MLLT3oncoprotein110.52714.450Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
NKAP (PF15692): NF-kappa-B-activating protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
75 MTM1interactor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
3-PAP (PF12578, IPR022587): Myotubularin-associated protein
76 MYBoncoprotein100.4677.150Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
77 MYEF2interactor70.4292.496RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
78 MYO5Cinteractor40.5001.733DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
YtxH (PF12732, IPR024623): YtxH-like protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
79 NCLprotein found in more fusions200.38046.512DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
80 NTRK1oncoprotein420.171443.469I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
81 OXTinteractor100Hormone_4 (PF00220, IPR022423): Neurohypophysial hormones, N-terminal Domain
Hormone_5 (PF00184, IPR000981, SM00003): Neurohypophysial hormones, C-terminal Domain
82 PAF1oncoprotein130.48721.990Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
83 PIH1D1interactor21.0000PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
84 PKN1interactor80.5713.049C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
85 POLR2Aprotein found in more fusions250.268125.085RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
86 PPIEinteractor31.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
87 PPP1R15Ainteractor21.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region
SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
88 PSIP1oncoprotein50.7000.801AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BEX (PF04538, IPR021156): Brain expressed X-linked like family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF)
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
89 RANoncoprotein140.37423.087Ras (PF00071, IPR001806, SM00173): Ras family
90 RARAoncoprotein80.7141.552zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
91 RBBP4oncoprotein270.44759.614eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
92 RBBP5oncoprotein220.37158.069WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
93 RBBP7suppressor220.55426.703WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
94 RNF2interactor310.290155.937zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
95 RUNX1suppressor140.48719.324Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
96 SAP30interactor90.9440.367Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
97 SBF1interactor30.6670.111dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
PH (PF00169, IPR001849, SM00233): PH domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
T2SSJ (PF11612, IPR010055): Type II secretion system (T2SS), protein J
SBF2 (PF12335, IPR022096): Myotubularin protein
98 SENP3interactor100.5786.968Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
99 SEToncoprotein100.4723.325NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
100 SHC1oncoprotein50.8330.133PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
101 SIN3Aoncoprotein310.376119.608Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
102 SIN3Binteractor130.64113.057Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
103 SIRT7interactor250.320100.819DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
104 SKP2suppressor60.4674.858LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
105 SMARCA2suppressor260.41569.881DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
106 SMARCB1suppressor170.55024.420SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
107 SMARCC1suppressor170.54215.028SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
108 SMARCC2interactor150.60011.040GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
109 SNW1protein found in more fusions280.279139.433SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
110 STAT1suppressor130.30326.815SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
111 SVILinteractor70.28613.500Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
112 SYMPKinteractor60.6671.744HEAT (PF02985, IPR000357): HEAT repeat
DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
Symplekin_C (PF12295, IPR022075): Symplekin tight junction protein C terminal
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
113 TAF1oncoprotein130.46220.269Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
Opi1 (PF08618, IPR013927): Transcription factor Opi1
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
114 TAF6interactor200.56824.032CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
115 TAF9interactor100.62211.334TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
116 TASP1interactor100Asparaginase_2 (PF01112, IPR000246): Asparaginase
117 TBPinteractor210.38456.016TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
118 TCEB1oncoprotein60.6004.000Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
119 TCEB2interactor70.4768.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
120 TOP1oncoprotein150.51418.304DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
121 TP53suppressor480.235444.554DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
122 TRAF3IP1interactor100MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
123 TRIM3suppressor50.5002.500C1_2 (PF03107, IPR004146): C1 domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
NHL (PF01436, IPR001258): NHL repeat
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
124 VDRsuppressor80.5243.298zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
125 WDR5interactor270.342111.433WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
126 WDR61interactor70.8101.571WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTN1interactorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
2 ACTN2interactorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 ACTN3interactorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 ACTN4parental proteinCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 AHNAKsuppressorDUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945)
ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein
DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993)
DUF4097 (PF13349, IPR025164): Putative adhesin
Ntox37 (PF15535, IPR029108): Bacterial toxin 37
6 ALDOAinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
7 ALDOCinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 ALKoncoproteinMAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
9 ANLNoncoproteinAnillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
10 BMP7interactorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
11 CAMK2AinteractorCaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CAMK2BoncoproteinCaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
13 CAPZA2interactorF-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
14 CCDC8interactorBorrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
15 CD81interactorTetraspannin (PF00335, IPR018499): Tetraspanin family
16 CDH1suppressorCadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
17 CKBinteractorATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
18 COL17A1interactorCollagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF2868 (PF11067, IPR021296): Protein of unknown function (DUF2868)
Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3
19 CYC1interactorCytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
20 DBN1oncoproteinPinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
21 ECSITinteractorECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
22 FLNAsuppressorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
23 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
24 GSNsuppressorGelsolin (PF00626, IPR007123): Gelsolin repeat
25 HSPB1oncoproteinHSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 ICAM1oncoproteinAdhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
27 IDH3AinteractorIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
28 IGSF8oncoproteinV-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
29 IQGAP1interactorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
30 ITGA4interactorFG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
31 KMT2Aparental proteinAT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
32 LIMA1suppressorLIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
33 MCFD2interactorEF-hand_7 (PF13499, IPR011992): EF-hand domain pair
34 MYH15interactorMyosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
35 MYH2interactorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
36 MYH7BinteractorMyosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
37 MYH9suppressorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
38 MYO18AinteractorVfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
39 MYO19interactorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
40 MYO1CinteractorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
41 MYOZ1interactorCalsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
42 MYOZ2interactorCalsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
43 NCAPG2interactorAdaptin_N (PF01602, IPR002553): Adaptin N terminal region
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
44 NOS3interactorFAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
45 OBSL1interactorBiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
46 PDLIM1interactorLIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
47 PDLIM7interactorLIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
48 POT1interactorPOT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
49 PPP1CBinteractorMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
50 PSMA3interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
51 PSMA6interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
52 PSMB5interactorProteasome (PF00227, IPR001353): Proteasome subunit
53 PSMB8interactorProteasome (PF00227, IPR001353): Proteasome subunit
54 PUS7interactorR3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
55 RPS27interactorRibosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
56 SACSinteractorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
HEPN (PF05168, IPR007842, SM00748): HEPN domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DUF4368 (PF14287, IPR025378): Domain of unknown function (DUF4368)
ThaI (PF15514, IPR029128): Restriction endonuclease ThaI
57 SF3A3interactorDUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
58 SLC2A4interactorSugar_tr (PF00083, IPR005828): Sugar (and other) transporter
59 SLC9A3R2interactorEBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
60 SYNPOinteractorCalsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
61 TJP1interactorDUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
62 TPM1interactorTropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
63 TPM2interactorDASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
64 TPM3oncoproteinTropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
65 TPM4oncoproteinTropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
66 TSG101suppressorAPG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
67 TXNoncoproteinThioredoxin (PF00085, IPR013766): Thioredoxin
68 UBASH3BinteractorHis_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
69 UBTFinteractorDicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
70 UCHL5oncoproteinPeptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
71 USP6NLinteractorFilament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
72 VCAM1interactorC2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
73 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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