Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: EU236945 is the fusion of parental proteins CD74, ROS1 (from a repository: Mon Nov 14 16:51:14 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors2 (12.50 %)
Total number of binary PPIs (saturation %)29 (24.17 %)
The number (and %) of affected PPIs15 (51.72 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.625
Assortativity coefficient-0.1072
The network average Clustering coefficient0.529
The number (and %) of a zero Clustering coefficients6 (37.50 %)
The number (and %) of a zero Betweenness Centrality14 (87.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ROS1,CD74 All fusions
: EU236945;
Proteins found in more fusions APP (see 4 fusions); GRB2 (see 1 fusions); COPG1 (see 1 fusions); PTPN11 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EU236945chimera150.057192.000MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 APPprotein found in more fusions200APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 COPG1protein found in more fusions31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
4 COPG2interactor31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
5 GRB2oncoprotein60.4006.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
6 HADHAinteractor1003HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
7 HLA-DPB1interactor100MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
8 HLA-DQA1interactor21.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
9 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
10 LAMTOR5interactor100LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
11 MAP3K1oncoprotein31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
12 MIFoncoprotein200MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
13 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
14 PTPN6suppressor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
15 TM4SF20interactor100L6_membrane (PF05805, IPR008661): L6 membrane protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
16 VAV3oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
PH_10 (PF15411): Pleckstrin homology domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CD74parental proteinMHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
2 ROS1parental proteinfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)

B a c k    t o    T o p ⇑