1 |
EF535849 | chimera | 247 | 0.060 | 38259.323 | zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
2 |
ACOT8 | interactor | 2 | 1.000 | 0 | 4HBT_3 (PF13622): Thioesterase-like superfamily |
3 |
ADH1B | interactor | 1 | 0 | 0 | ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase |
4 |
AJUBA | oncoprotein | 3 | 0.667 | 1.000 | LIM (PF00412, IPR001781, SM00132): LIM domain |
5 |
AKT1 | oncoprotein | 31 | 0.230 | 179.258 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
6 |
ANKRD2 | interactor | 2 | 1.000 | 0 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
7 |
ARID3A | interactor | 5 | 0.400 | 2.955 | ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Nop14 (PF04147, IPR007276): Nop14-like family TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
8 |
ARIH2 | protein found in more fusions | 7 | 0.733 | 0.665 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1 |
9 |
ARNT | oncoprotein | 8 | 0.536 | 3.298 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1 |
10 |
ASF1A | interactor | 5 | 0.500 | 2.730 | ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone |
11 |
ATF2 | oncoprotein | 21 | 0.384 | 51.408 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type |
12 |
ATF7IP | oncoprotein | 6 | 0.600 | 3.051 | TCP (PF03634, IPR005333): TCP family transcription factor DUF2951 (PF11166, IPR021337): Protein of unknown function (DUF2951) ALMT (PF11744, IPR020966): Aluminium activated malate transporter ATF7IP_BD (PF16788, IPR031870): ATF-interacting protein binding domain fn3_4 (PF16794, IPR003961): Fibronectin-III type domain |
13 |
ATP5J2 | interactor | 3 | 0.667 | 1.000 | WRW (PF10206, IPR019344): Mitochondrial F1F0-ATP synthase, subunit f |
14 |
ATRX | oncoprotein | 11 | 0.345 | 18.969 | DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) |
15 |
ATXN1 | protein found in more fusions | 16 | 0.286 | 42.936 | AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term |
16 |
ATXN3 | interactor | 13 | 0.318 | 23.171 | Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
17 |
AURKA | oncoprotein | 21 | 0.279 | 85.350 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
18 |
AXIN1 | suppressor | 12 | 0.436 | 10.612 | Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain |
19 |
BAG1 | oncoprotein | 10 | 0.356 | 15.459 | BAG (PF02179, IPR003103, SM00264): BAG domain Presenilin (PF01080, IPR001108): Presenilin ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
20 |
BANP | suppressor | 15 | 0.560 | 13.881 | DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845) BEN (PF10523, IPR018379, SM01025): BEN domain |
21 |
BCL2 | oncoprotein | 14 | 0.423 | 22.245 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
22 |
BCL6 | oncoprotein | 22 | 0.433 | 37.786 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger |
23 |
C1QTNF6 | interactor | 1 | 0 | 0 | C1q (PF00386, IPR001073, SM00110): C1q domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) |
24 |
CASP8AP2 | interactor | 7 | 0.800 | 1.111 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) IncA (PF04156, IPR007285): IncA protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR |
25 |
CBX5 | suppressor | 19 | 0.222 | 66.388 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain |
26 |
CCNT1 | oncoprotein | 6 | 0.700 | 2.400 | Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit MDFI (PF15316, IPR026134): MyoD family inhibitor |
27 |
CDK1 | oncoprotein | 22 | 0.362 | 43.497 | Pkinase (PF00069, IPR000719): Protein kinase domain |
28 |
CDK2 | suppressor | 30 | 0.397 | 83.405 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
29 |
CDK6 | suppressor | 16 | 0.352 | 28.318 | Pkinase (PF00069, IPR000719): Protein kinase domain |
30 |
CDKN2A | suppressor | 23 | 0.391 | 60.244 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
31 |
CHD4 | oncoprotein | 21 | 0.384 | 42.165 | CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Coilin_N (PF15862, IPR031722): Coilin N-terminus |
32 |
CHEK2 | suppressor | 13 | 0.409 | 14.545 | FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain |
33 |
CHFR | suppressor | 13 | 0.424 | 13.034 | FHA (PF00498, IPR000253, SM00240): FHA domain Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92 zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) LAX (PF15681, IPR031393): Lymphocyte activation family X |
34 |
COLGALT1 | interactor | 4 | 0.667 | 1.286 | Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2 |
35 |
CREBBP | suppressor | 60 | 0.271 | 499.142 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) |
36 |
CSNK1D | interactor | 7 | 0.619 | 3.116 | Pkinase (PF00069, IPR000719): Protein kinase domain |
37 |
CSNK2A1 | oncoprotein | 37 | 0.273 | 190.593 | Pkinase (PF00069, IPR000719): Protein kinase domain |
38 |
CSNK2A3 | interactor | 1 | 0 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
39 |
CSNK2B | interactor | 20 | 0.345 | 48.569 | CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit |
40 |
CTNNB1 | oncoprotein | 41 | 0.233 | 301.198 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
41 |
CUL1 | suppressor | 30 | 0.256 | 160.322 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
42 |
DAXX | oncoprotein | 33 | 0.290 | 154.436 | Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) |
43 |
DNM2 | interactor | 7 | 0.476 | 3.922 | Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family |
44 |
DPH7 | interactor | 1 | 0 | 0 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
45 |
DSN1 | interactor | 3 | 0.667 | 1.000 | MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family |
46 |
E2F1 | suppressor | 21 | 0.395 | 51.054 | Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
47 |
E2F4 | suppressor | 10 | 0.467 | 8.710 | E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone SPX (PF03105, IPR004331): SPX domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
48 |
ECT2 | suppressor | 7 | 0.429 | 7.986 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal |
49 |
EGFR | oncoprotein | 33 | 0.190 | 250.925 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
50 |
EHMT2 | interactor | 10 | 0.500 | 8.381 | CDC45 (PF02724, IPR003874): CDC45-like protein Pre-SET (PF05033, IPR007728): Pre-SET motif Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family SET (PF00856, IPR001214, SM00317): SET domain SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus |
51 |
EIF4E | oncoprotein | 4 | 0.500 | 1.175 | IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E |
52 |
ELF4 | oncoprotein | 4 | 0.667 | 0.508 | Ets (PF00178, IPR000418, SM00413): Ets-domain Elf-1_N (PF12310, IPR022084): Transcription factor protein N terminal |
53 |
EME1 | interactor | 4 | 0.667 | 0.800 | ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain |
54 |
EP300 | oncoprotein | 73 | 0.232 | 875.052 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
55 |
EZH2 | suppressor | 30 | 0.261 | 135.777 | CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
56 |
FAS | suppressor | 11 | 0.400 | 12.521 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH |
57 |
FBXO3 | interactor | 6 | 0.667 | 1.560 | DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525) Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A SMI1_KNR4 (PF09346, IPR018958, SM00860): SMI1 / KNR4 family (SUKH-1) F-box-like (PF12937, IPR001810): F-box-like PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated |
58 |
FHL3 | interactor | 9 | 0.464 | 6.695 | LIM (PF00412, IPR001781, SM00132): LIM domain Med27 (PF11571, IPR021627): Mediator complex subunit 27 |
59 |
FIP1L1 | oncoprotein | 6 | 0.533 | 2.441 | Fip1 (PF05182, IPR007854): Fip1 motif Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 (PF14851): FAM176 family Auts2 (PF15336): Autism susceptibility gene 2 protein |
60 |
FN1 | oncoprotein | 21 | 0.290 | 68.566 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
61 |
FOS | oncoprotein | 27 | 0.348 | 86.892 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor |
62 |
FOXO1 | suppressor | 13 | 0.576 | 5.675 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
63 |
GATA1 | oncoprotein | 13 | 0.500 | 15.813 | GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain |
64 |
GATA2 | oncoprotein | 13 | 0.359 | 25.281 | GATA (PF00320, IPR000679, SM00401): GATA zinc finger |
65 |
GLIS2 | interactor | 3 | 0.667 | 0.667 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
66 |
GOLGA6A | interactor | 1 | 0 | 0 | DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Erythro-docking (PF09277, IPR015357): Erythronolide synthase, docking Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5 |
67 |
H2AFX | suppressor | 17 | 0.331 | 39.433 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
68 |
H3F3A | oncoprotein | 12 | 0.394 | 23.495 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
69 |
HACE1 | suppressor | 2 | 0 | 0 | HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) |
70 |
HDAC1 | suppressor | 73 | 0.213 | 948.476 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
71 |
HDAC11 | interactor | 7 | 0.286 | 11.060 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
72 |
HDAC2 | suppressor | 50 | 0.241 | 373.428 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
73 |
HDAC3 | suppressor | 48 | 0.240 | 378.278 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
74 |
HDAC4 | oncoprotein | 34 | 0.280 | 163.762 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
75 |
HDAC6 | oncoprotein | 22 | 0.262 | 70.974 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
76 |
HDAC7 | protein found in more fusions | 15 | 0.538 | 8.123 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO |
77 |
HHEX | oncoprotein | 2 | 1.000 | 0 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated |
78 |
HIPK2 | suppressor | 25 | 0.351 | 87.938 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
79 |
HIRA | suppressor | 4 | 0.667 | 1.000 | Hira (PF07569, IPR011494): TUP1-like enhancer of split HIRA_B (PF09453, IPR019015): HIRA B motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Mcl1_mid (PF12341, IPR022100): Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain |
80 |
HMGXB4 | oncoprotein | 4 | 0.667 | 1.067 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF4171 (PF13775, IPR025228): Domain of unknown function (DUF4171) RMP (PF14996, IPR029239): Retinal Maintenance |
81 |
HNRNPU | interactor | 24 | 0.362 | 90.230 | CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
82 |
HOMER3 | protein found in more fusions | 2 | 0 | 0 | COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper |
83 |
HTT | protein found in more fusions | 14 | 0.423 | 18.635 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
84 |
IER3 | suppressor | 4 | 0.667 | 0.508 | FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
85 |
IFI16 | suppressor | 16 | 0.317 | 44.618 | HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein |
86 |
IKBKE | interactor | 6 | 0.400 | 3.452 | IncA (PF04156, IPR007285): IncA protein Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon |
87 |
INTS7 | interactor | 1 | 0 | 0 | DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453) TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat HEAT_2 (PF13646): HEAT repeats FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2 SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking |
88 |
IRX4 | interactor | 1 | 0 | 0 | Homeobox_KN (PF05920, IPR008422): Homeobox KN domain |
89 |
JAK1 | oncoprotein | 12 | 0.418 | 17.186 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
90 |
JUN | oncoprotein | 45 | 0.330 | 227.088 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor |
91 |
KAT5 | suppressor | 33 | 0.361 | 112.246 | MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain |
92 |
KAT6A | oncoprotein | 9 | 0.500 | 8.879 | BUD22 (PF09073, IPR015158): BUD22 MOZ_SAS (PF01853, IPR002717): MOZ/SAS family PHD (PF00628, IPR019787, SM00249): PHD-finger Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) zf-met (PF12874): Zinc-finger of C2H2 type |
93 |
KDM5A | suppressor | 7 | 0.762 | 1.021 | ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain FRG1 (PF06229, IPR010414): FRG1-like domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542 |
94 |
KLF5 | suppressor | 19 | 0.614 | 12.951 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
95 |
KLHL20 | interactor | 5 | 0.500 | 1.556 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
96 |
KNL1 | oncoprotein | 3 | 0.667 | 1.000 | DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
97 |
KRAS | oncoprotein | 10 | 0.333 | 16.287 | Ras (PF00071, IPR001806, SM00173): Ras family |
98 |
LIMD1 | suppressor | 6 | 0.400 | 4.167 | LIM (PF00412, IPR001781, SM00132): LIM domain |
99 |
LMNA | protein found in more fusions | 18 | 0.441 | 28.152 | Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
100 |
MAF | oncoprotein | 9 | 0.679 | 1.780 | bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein Metal_resist (PF13801, IPR025961): Heavy-metal resistance |
101 |
MAGEA2 | interactor | 4 | 0.667 | 0.224 | MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal |
102 |
MAP1LC3B | interactor | 5 | 0.600 | 1.852 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
103 |
MAP2K4 | suppressor | 6 | 0.600 | 1.033 | Pkinase (PF00069, IPR000719): Protein kinase domain |
104 |
MAPK1 | oncoprotein | 29 | 0.299 | 140.658 | Pkinase (PF00069, IPR000719): Protein kinase domain |
105 |
MAPK11 | interactor | 4 | 0.500 | 0.425 | HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Pkinase (PF00069, IPR000719): Protein kinase domain |
106 |
MAPK3 | oncoprotein | 19 | 0.333 | 54.344 | Pkinase (PF00069, IPR000719): Protein kinase domain |
107 |
MAPK6 | oncoprotein | 7 | 0.333 | 8.667 | Pkinase (PF00069, IPR000719): Protein kinase domain |
108 |
MAPK7 | oncoprotein | 6 | 0.500 | 1.007 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
109 |
MDM2 | oncoprotein | 54 | 0.205 | 594.913 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
110 |
MECR | interactor | 2 | 1.000 | 0 | ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase |
111 |
MED7 | interactor | 5 | 0.600 | 2.750 | Med7 (PF05983, IPR009244): MED7 protein DotU (PF09850, IPR017732): Type VI secretion system protein DotU |
112 |
MMS19 | interactor | 8 | 0.500 | 4.872 | DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
113 |
MRTO4 | interactor | 7 | 0.524 | 5.590 | Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10 |
114 |
MTA2 | interactor | 16 | 0.483 | 21.265 | BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger |
115 |
MTOR | oncoprotein | 16 | 0.276 | 37.035 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
116 |
MYB | oncoprotein | 17 | 0.412 | 31.026 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
117 |
MYC | oncoprotein | 51 | 0.244 | 490.240 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
118 |
NACC1 | interactor | 7 | 0.600 | 1.371 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain BEN (PF10523, IPR018379, SM01025): BEN domain |
119 |
NANP | interactor | 1 | 0 | 0 | HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase |
120 |
NCOA1 | oncoprotein | 29 | 0.368 | 98.221 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein |
121 |
NCOA2 | oncoprotein | 14 | 0.538 | 20.445 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein |
122 |
NCOA3 | oncoprotein | 28 | 0.384 | 102.789 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
123 |
NCOR1 | oncoprotein | 37 | 0.356 | 167.984 | BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region |
124 |
NCOR2 | oncoprotein | 37 | 0.369 | 139.030 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) |
125 |
NFATC1 | oncoprotein | 15 | 0.524 | 10.089 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
126 |
NFKB1 | suppressor | 30 | 0.419 | 78.829 | Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
127 |
NKX2-1 | oncoprotein | 7 | 0.714 | 1.587 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719) |
128 |
NPM1 | suppressor | 37 | 0.303 | 197.815 | Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain |
129 |
NR1H2 | oncoprotein | 14 | 0.462 | 17.740 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
130 |
NR1I3 | interactor | 6 | 0.867 | 0.389 | PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
131 |
NR2C1 | interactor | 9 | 0.694 | 2.555 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
132 |
NR2E3 | interactor | 4 | 0.833 | 0.105 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
133 |
NR3C1 | protein found in more fusions | 38 | 0.354 | 160.188 | GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
134 |
NR4A1 | suppressor | 22 | 0.346 | 69.587 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
135 |
NSD1 | oncoprotein | 5 | 0.700 | 1.667 | PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain SET (PF00856, IPR001214, SM00317): SET domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain |
136 |
NTRK1 | oncoprotein | 54 | 0.152 | 722.365 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
137 |
PARK7 | suppressor | 14 | 0.513 | 12.325 | DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family |
138 |
PARP1 | suppressor | 40 | 0.279 | 234.255 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
139 |
PCBD2 | interactor | 3 | 0.667 | 0.667 | Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase |
140 |
PER2 | suppressor | 5 | 0.800 | 0.867 | PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region |
141 |
PHF8 | interactor | 4 | 0.500 | 1.133 | JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase PHD (PF00628, IPR019787, SM00249): PHD-finger TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1 AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region |
142 |
PIAS1 | suppressor | 29 | 0.275 | 114.613 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544 |
143 |
PIAS2 | protein found in more fusions | 20 | 0.363 | 41.585 | SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain |
144 |
PIN1 | suppressor | 27 | 0.365 | 105.528 | Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain |
145 |
PKM | oncoprotein | 20 | 0.368 | 50.187 | PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain |
146 |
PLAGL1 | suppressor | 9 | 0.806 | 1.146 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger |
147 |
PLCG1 | oncoprotein | 9 | 0.500 | 13.544 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
148 |
PLOD3 | protein found in more fusions | 7 | 0.467 | 6.567 | 2OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily Anp1 (PF03452, IPR005109): Anp1 |
149 |
PLSCR1 | interactor | 7 | 0.381 | 6.984 | Scramblase (PF03803, IPR005552): Scramblase |
150 |
POLR2E | protein found in more fusions | 7 | 0.333 | 3.047 | RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain |
151 |
PPARG | suppressor | 41 | 0.371 | 177.178 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region |
152 |
PPARGC1A | interactor | 20 | 0.395 | 46.149 | Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1 |
153 |
PRAME | interactor | 4 | 0.667 | 0.667 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) |
154 |
PRDX6 | protein found in more fusions | 11 | 0.511 | 10.189 | AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin |
155 |
PSMA3 | interactor | 20 | 0.240 | 76.651 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
156 |
PSME3 | protein found in more fusions | 13 | 0.561 | 7.797 | PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit |
157 |
PYCARD | suppressor | 4 | 1.000 | 0 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain |
158 |
RAD51 | interactor | 12 | 0.400 | 18.094 | Rad51 (PF08423, IPR013632): Rad51 HHH_5 (PF14520): Helix-hairpin-helix domain |
159 |
RANBP2 | oncoprotein | 17 | 0.375 | 31.822 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
160 |
RB1 | suppressor | 42 | 0.272 | 281.570 | RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592) |
161 |
RBCK1 | interactor | 4 | 0.667 | 0.500 | GAGA (PF09237, IPR015318): GAGA factor IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger |
162 |
RBL2 | suppressor | 12 | 0.409 | 13.405 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pap_E4 (PF02711, IPR003861): E4 protein RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain SLH (PF00395, IPR001119): S-layer homology domain TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) |
163 |
RBX1 | oncoprotein | 12 | 0.364 | 20.332 | zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain |
164 |
RELA | oncoprotein | 45 | 0.317 | 277.589 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
165 |
RFC4 | interactor | 8 | 0.607 | 6.554 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain |
166 |
RFPL4B | interactor | 5 | 0.500 | 3.452 | SPRY (PF00622, IPR003877, SM00449): SPRY domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
167 |
RNF111 | suppressor | 12 | 0.400 | 10.487 | zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus |
168 |
RNF125 | interactor | 6 | 0.400 | 3.452 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
169 |
RNF4 | interactor | 11 | 0.400 | 9.685 | Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger |
170 |
RPL11 | suppressor | 13 | 0.628 | 7.593 | Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5 Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus |
171 |
RPL5 | suppressor | 16 | 0.438 | 32.096 | Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18 |
172 |
RUNX1 | suppressor | 26 | 0.353 | 89.109 | Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037) |
173 |
RUNX2 | suppressor | 17 | 0.500 | 16.981 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Runt (PF00853, IPR013524): Runt domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722) |
174 |
RUNX3 | suppressor | 10 | 0.667 | 4.106 | Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain |
175 |
RXRA | oncoprotein | 36 | 0.301 | 182.641 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1 |
176 |
SAP130 | interactor | 9 | 0.583 | 7.115 | SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus |
177 |
SAP25 | interactor | 5 | 0.700 | 1.015 | SAP25 (PF15476, IPR029163): Histone deacetylase complex subunit SAP25 |
178 |
SATB1 | oncoprotein | 14 | 0.462 | 14.420 | CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
179 |
SENP1 | protein found in more fusions | 15 | 0.429 | 19.865 | Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain |
180 |
SETDB1 | interactor | 11 | 0.418 | 12.656 | MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537) PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator |
181 |
SF1 | protein found in more fusions | 16 | 0.267 | 45.750 | UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain |
182 |
SFXN3 | interactor | 6 | 0.400 | 8.667 | Mtc (PF03820, IPR004686): Tricarboxylate carrier |
183 |
SH3GL1 | oncoprotein | 5 | 0.500 | 1.389 | BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
184 |
SIAH1 | suppressor | 15 | 0.330 | 25.587 | Sina (PF03145, IPR018121): Seven in absentia protein family |
185 |
SIAH2 | oncoprotein | 12 | 0.473 | 10.254 | Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
186 |
SIN3A | oncoprotein | 33 | 0.280 | 175.365 | Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein |
187 |
SIRT1 | suppressor | 38 | 0.279 | 188.723 | DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain |
188 |
SKI | oncoprotein | 22 | 0.390 | 46.349 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
189 |
SKIL | suppressor | 18 | 0.368 | 32.125 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115) |
190 |
SKP1 | oncoprotein | 13 | 0.385 | 22.208 | Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain |
191 |
SLC1A2 | interactor | 3 | 0.667 | 1.000 | SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209) |
192 |
SMAD2 | suppressor | 31 | 0.386 | 96.800 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
193 |
SMAD3 | oncoprotein | 51 | 0.252 | 400.275 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
194 |
SMARCA4 | suppressor | 43 | 0.275 | 280.817 | DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
195 |
SMARCD3 | interactor | 5 | 0.800 | 0.220 | SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain |
196 |
SNRNP40 | interactor | 3 | 0.667 | 0.667 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
197 |
SNX11 | interactor | 2 | 1.000 | 0 | PX (PF00787, IPR001683, SM00312): PX domain |
198 |
SP1 | protein found in more fusions | 42 | 0.352 | 207.018 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
199 |
SP100 | suppressor | 14 | 0.423 | 28.121 | Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
200 |
SPI1 | suppressor | 13 | 0.538 | 9.589 | Ets (PF00178, IPR000418, SM00413): Ets-domain p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain |
201 |
SQSTM1 | oncoprotein | 24 | 0.253 | 115.671 | PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain |
202 |
SRC | oncoprotein | 18 | 0.397 | 34.948 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
203 |
SRF | interactor | 15 | 0.637 | 5.139 | SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) |
204 |
STAT1 | suppressor | 24 | 0.407 | 50.327 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
205 |
STAT2 | oncoprotein | 6 | 0.733 | 0.550 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT2_C (PF12188, IPR022756): Signal transducer and activator of transcription 2 C terminal |
206 |
STAT3 | suppressor | 33 | 0.323 | 139.416 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
207 |
SUMO1 | interactor | 39 | 0.205 | 273.483 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
208 |
SUMO2 | interactor | 32 | 0.194 | 213.306 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
209 |
SUMO3 | interactor | 11 | 0.400 | 13.165 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
210 |
SUV39H1 | protein found in more fusions | 23 | 0.342 | 64.452 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain |
211 |
SUZ12 | suppressor | 23 | 0.281 | 87.080 | DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein |
212 |
SYNE2 | oncoprotein | 4 | 0.667 | 1.333 | ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit Fez1 (PF06818): Fez1 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Laminin_II (PF06009, IPR010307): Laminin Domain II Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Occludin_ELL (PF07303, IPR010844): Occludin homology domain SlyX (PF04102, IPR007236): SlyX Spectrin (PF00435, IPR002017): Spectrin repeat TMPIT (PF07851, IPR012926): TMPIT-like protein KASH (PF10541, IPR012315): Nuclear envelope localisation domain HD_5 (PF13487): HD domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM |
213 |
TBC1D14 | interactor | 2 | 1.000 | 0 | Sds3 (PF08598, IPR013907): Sds3-like RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family |
214 |
TBX2 | oncoprotein | 1 | 0 | 0 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein T-box (PF00907, IPR001699, SM00425): T-box TBX (PF12598, IPR022582): T-box transcription factor |
215 |
TBX3 | oncoprotein | 6 | 0.500 | 1.019 | T-box (PF00907, IPR001699, SM00425): T-box TBX (PF12598, IPR022582): T-box transcription factor |
216 |
TCF7L2 | suppressor | 7 | 0.619 | 2.264 | CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box |
217 |
TCTN3 | interactor | 2 | 1.000 | 0 | DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619) |
218 |
TDG | interactor | 14 | 0.473 | 13.763 | Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily |
219 |
TERF2IP | protein found in more fusions | 10 | 0.250 | 16.716 | BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
220 |
TERT | oncoprotein | 7 | 0.667 | 1.672 | RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain |
221 |
TGIF1 | oncoprotein | 6 | 0.867 | 0.325 | Homeobox_KN (PF05920, IPR008422): Homeobox KN domain LRS4 (PF10422, IPR018479): Monopolin complex subunit LRS4 |
222 |
TIMM23 | interactor | 3 | 0.667 | 0.500 | Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family |
223 |
TNIP1 | interactor | 8 | 0.286 | 8.367 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
224 |
TOMM20 | interactor | 5 | 0.500 | 4.167 | RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate MAS20 (PF02064, IPR002056): MAS20 protein import receptor |
225 |
TOP2B | oncoprotein | 17 | 0.471 | 27.543 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DASH_Spc19 (PF08287, IPR013251): Spc19 DNA_gyraseB (PF00204, IPR013506): DNA gyrase B DTHCT (PF08070, IPR012542): DTHCT (NUC029) region HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim (PF01751, IPR006171, SM00493): Toprim domain Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM |
226 |
TOPBP1 | protein found in more fusions | 6 | 0.500 | 1.801 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
227 |
TOPORS | suppressor | 10 | 0.467 | 11.124 | Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
228 |
TP53 | suppressor | 101 | 0.136 | 2589.992 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
229 |
TP63 | suppressor | 17 | 0.467 | 26.685 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
230 |
TRIM24 | suppressor | 10 | 0.417 | 10.625 | PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Siva (PF05458, IPR022773): Cd27 binding protein (Siva) zf-MYND (PF01753, IPR002893): MYND finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 Imm68 (PF15583, IPR028276): Immunity protein 68 SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 |
231 |
TRIM27 | oncoprotein | 24 | 0.296 | 107.568 | IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease |
232 |
TRIM32 | suppressor | 9 | 0.321 | 12.570 | NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
233 |
TRIM69 | interactor | 3 | 1.000 | 0 | DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) SPRY (PF00622, IPR003877, SM00449): SPRY domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain DZR (PF12773, IPR025874): Double zinc ribbon zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
234 |
UBE2I | interactor | 79 | 0.166 | 1392.427 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
235 |
UBE2U | interactor | 8 | 0.321 | 12.733 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal TMEM154 (PF15102, IPR028064): TMEM154 protein family |
236 |
UBE3A | oncoprotein | 10 | 0.306 | 17.539 | HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A |
237 |
UBQLN1 | protein found in more fusions | 12 | 0.255 | 22.190 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X |
238 |
UHRF1 | interactor | 17 | 0.383 | 32.447 | PHD (PF00628, IPR019787, SM00249): PHD-finger SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1 zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2 |
239 |
UQCRQ | interactor | 3 | 0.667 | 1.000 | UcrQ (PF02939, IPR004205): UcrQ family |
240 |
USP7 | oncoprotein | 28 | 0.265 | 117.581 | MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal |
241 |
WDR5 | interactor | 15 | 0.295 | 46.028 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
242 |
WRN | oncoprotein | 13 | 0.409 | 12.100 | DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease DEAD (PF00270, IPR011545): DEAD/DEAH box helicase HRDC (PF00570, IPR002121, SM00341): HRDC domain Laminin_II (PF06009, IPR010307): Laminin Domain II RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain HTH_40 (PF14493, IPR029491): Helix-turn-helix domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding |
243 |
WWOX | suppressor | 10 | 0.422 | 12.298 | adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain |
244 |
YAP1 | suppressor | 12 | 0.439 | 12.321 | Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181 |
245 |
ZBTB16 | suppressor | 29 | 0.336 | 107.312 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger |
246 |
ZFYVE9 | interactor | 5 | 1.000 | 0 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger SARA (PF11409, IPR024608): Smad anchor for receptor activation (SARA) DUF3480 (PF11979, IPR022557): Domain of unknown function (DUF3480) |
247 |
ZMYM2 | oncoprotein | 9 | 0.444 | 12.202 | YHS (PF04945, IPR007029): YHS domain zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504) SOBP (PF15279, IPR026092): Sine oculis-binding protein |
248 |
ZNF506 | interactor | 1 | 0 | 0 | Antimicrobial14 (PF08109, IPR012517): Lactocin 705 family KRAB (PF01352, IPR001909, SM00349): KRAB box ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |