Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	150
The number (and %) of the onco-proteins	55 (36.67 %)
The number (and %) of the tumor suppressors	41 (27.33 %)
Total number of binary PPIs (saturation %)	991 (8.87 %)
The number (and %) of affected PPIs	149 (15.04 %)
The number of possible different fusions	37
PPI diameter	2
PPI radius	1
The average degree of PPI	12.227
Assortativity coefficient	-0.2823
The network average Clustering coefficient	0.486
The number (and %) of a zero Clustering coefficients	11 (7.33 %)
The number (and %) of a zero Betweenness Centrality	28 (18.67 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RARA,PRKAR1A	All fusions : EF428111;
Proteins found in more fusions	ILK (see 1 fusions); POU2F1 (see 1 fusions); FOXO1 (see 1 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); CUL3 (see 1 fusions); HDAC4 (see 1 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); SIAH1 (see 4 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); SP1 (see 1 fusions); RUNX1 (see 1 fusions); CREBBP (see 6 fusions); UBQLN1 (see 2 fusions); KAT2B (see 1 fusions); SETD7 (see 2 fusions); EGFR (see 2 fusions); SKI (see 1 fusions); PJA2 (see 1 fusions); RXRA (see 2 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PRDX6 (see 1 fusions); PRPF40A (see 2 fusions); SUV39H1 (see 1 fusions); PSMC5 (see 2 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions);

List of the fusions

PPI for parental proteins: RARA,PRKAR1A

All fusions

: EF428111;

Proteins found in more fusions

ILK (see 1 fusions); POU2F1 (see 1 fusions); FOXO1 (see 1 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); CUL3 (see 1 fusions); HDAC4 (see 1 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); SIAH1 (see 4 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); SP1 (see 1 fusions); RUNX1 (see 1 fusions); CREBBP (see 6 fusions); UBQLN1 (see 2 fusions); KAT2B (see 1 fusions); SETD7 (see 2 fusions); EGFR (see 2 fusions); SKI (see 1 fusions); PJA2 (see 1 fusions); RXRA (see 2 fusions); PARP1 (see 1 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PRDX6 (see 1 fusions); PRPF40A (see 2 fusions); SUV39H1 (see 1 fusions); PSMC5 (see 2 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EF428111	chimera	149	0.070	14482.784	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
2	ACTN4	interactor	5	0.700	1.050	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
3	AJUBA	oncoprotein	4	0.667	2.000	LIM (PF00412, IPR001781, SM00132): LIM domain
4	AKAP10	interactor	1	0	0	RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
5	AKT1	oncoprotein	22	0.333	64.272	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6	ARID1A	suppressor	7	0.571	5.122	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
7	ARID5A	oncoprotein	2	1.000	0	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
8	ARNTL	suppressor	11	0.527	12.209	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain
9	BAG1	oncoprotein	3	0.667	1.000	BAG (PF02179, IPR003103, SM00264): BAG domain Presenilin (PF01080, IPR001108): Presenilin ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
10	BAHD1	interactor	4	1.000	0	BAH (PF01426, IPR001025, SM00439): BAH domain
11	CAPN11	interactor	1	0	0	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12	CBX5	suppressor	7	0.333	5.586	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
13	CCDC8	interactor	15	0.363	31.784	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
14	CCND3	oncoprotein	7	0.429	8.248	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
15	CCNE1	oncoprotein	8	0.500	5.169	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
16	CDK2	suppressor	25	0.275	111.898	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
17	CEBPA	suppressor	14	0.372	24.027	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
18	CEP250	interactor	7	0.429	8.286	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
19	CLOCK	interactor	10	0.578	10.976	DivIC (PF04977, IPR007060): Septum formation initiator HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) PAS (PF00989, IPR013767, SM00091): PAS fold RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4 PAS_11 (PF14598): PAS domain FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
20	CREBBP	suppressor	42	0.246	328.113	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
21	CUL3	protein found in more fusions	27	0.212	166.550	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
22	DYRK1A	oncoprotein	9	0.536	6.608	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
23	DYRK1B	oncoprotein	8	0.524	5.769	Pkinase (PF00069, IPR000719): Protein kinase domain
24	E2F1	suppressor	18	0.431	36.958	Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
25	EGFR	oncoprotein	17	0.325	48.027	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26	ELAVL1	oncoprotein	39	0.169	405.557	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27	EP300	oncoprotein	42	0.260	307.306	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
28	EZH2	suppressor	19	0.373	47.966	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
29	FAS	suppressor	9	0.286	15.400	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
30	FN1	oncoprotein	22	0.255	104.210	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
31	FOXO1	suppressor	13	0.500	11.026	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
32	FRMD5	interactor	1	0	0	FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
33	GADD45A	suppressor	8	0.381	6.975	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
34	GADD45G	suppressor	5	0.500	3.667	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
35	GRB2	oncoprotein	14	0.487	15.194	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
36	GSK3B	suppressor	17	0.342	36.486	Pkinase (PF00069, IPR000719): Protein kinase domain
37	HACE1	suppressor	2	0	0	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
38	HDAC1	suppressor	38	0.219	300.454	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
39	HDAC2	suppressor	31	0.299	152.880	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
40	HDAC3	suppressor	31	0.260	167.642	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
41	HDAC4	oncoprotein	16	0.467	22.391	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
42	HIVEP1	suppressor	2	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_7 (PF15269): Zinc-finger
43	HMGA1	oncoprotein	11	0.618	7.292	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
44	HNRNPU	interactor	23	0.285	113.749	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
45	HR	interactor	4	0.667	0.259	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
46	HSP90AA4P	interactor	1	0	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
47	ILK	suppressor	11	0.489	9.940	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
48	IRX4	interactor	1	0	0	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
49	ITGB1BP2	interactor	1	0	0	CHORD (PF04968, IPR007051): CHORD CS (PF04969, IPR007052): CS domain
50	KAT2B	protein found in more fusions	22	0.386	61.235	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
51	KDM5A	suppressor	5	1.000	0	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain FRG1 (PF06229, IPR010414): FRG1-like domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
52	KLF5	suppressor	15	0.495	18.245	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
53	LIMD1	suppressor	4	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain
54	LRIF1	interactor	6	0.400	5.000	LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
55	MAPK1	oncoprotein	15	0.363	31.871	Pkinase (PF00069, IPR000719): Protein kinase domain
56	MAPK6	oncoprotein	6	0.500	3.667	Pkinase (PF00069, IPR000719): Protein kinase domain
57	MBD3	interactor	9	0.536	9.644	DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
58	MDM2	oncoprotein	32	0.228	209.981	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
59	MECR	interactor	1	0	0	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
60	MED1	interactor	14	0.321	28.874	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
61	MED25	interactor	7	0.667	2.039	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1 Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
62	MED6	interactor	6	0.467	3.519	Med6 (PF04934, IPR007018): MED6 mediator sub complex component Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
63	MMS19	interactor	9	0.472	12.186	DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
64	MRTO4	interactor	8	0.500	5.307	Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
65	MTA2	interactor	10	0.533	10.382	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
66	MTOR	oncoprotein	15	0.308	36.359	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
67	MYO7A	interactor	1	0	0	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain
68	NCOA1	oncoprotein	20	0.363	61.282	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
69	NCOA2	oncoprotein	11	0.582	9.656	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
70	NCOA3	oncoprotein	25	0.287	109.512	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
71	NCOA6	oncoprotein	17	0.425	28.623	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
72	NCOR1	oncoprotein	23	0.375	70.780	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
73	NCOR2	oncoprotein	24	0.420	62.712	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
74	NKX2-1	oncoprotein	5	1.000	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
75	NPAS2	suppressor	8	0.857	0.906	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold DehI (PF10778, IPR019714): Halocarboxylic acid dehydrogenase DehI PAS_11 (PF14598): PAS domain
76	NPM1	suppressor	25	0.351	87.797	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
77	NR0B2	suppressor	11	0.364	13.635	Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
78	NR1H2	oncoprotein	16	0.367	43.344	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
79	NR2E3	interactor	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
80	NRBF2	interactor	2	1.000	0	NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
81	NRIP1	oncoprotein	10	0.378	12.371	ALMT (PF11744, IPR020966): Aluminium activated malate transporter NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3 NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
82	NSD1	oncoprotein	2	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain SET (PF00856, IPR001214, SM00317): SET domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
83	NUAK1	suppressor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
84	PALM2-AKAP2	interactor	2	1.000	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
85	PARP1	suppressor	26	0.353	88.990	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
86	PATZ1	oncoprotein	2	0	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
87	PHF8	interactor	3	0.667	0.400	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase PHD (PF00628, IPR019787, SM00249): PHD-finger TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1 AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
88	PIN1	suppressor	15	0.343	40.569	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
89	PJA2	protein found in more fusions	5	0.833	0.167	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
90	PLEKHF2	interactor	2	1.000	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger PH (PF00169, IPR001849, SM00233): PH domain
91	PML	suppressor	42	0.204	413.710	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
92	POU2F1	protein found in more fusions	9	0.643	4.947	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
93	PPP1CA	suppressor	18	0.255	57.140	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
94	PRAM1	interactor	5	0.600	2.452	hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
95	PRAME	interactor	4	0.667	0.333	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
96	PRDX6	protein found in more fusions	5	0.833	0.222	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
97	PRKACA	interactor	12	0.258	39.689	Pkinase (PF00069, IPR000719): Protein kinase domain
98	PRKACB	interactor	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
99	PRKACG	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
100	PRKX	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
101	PRPF40A	protein found in more fusions	7	0.600	3.367	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
102	PSMC5	protein found in more fusions	15	0.396	21.806	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain
103	RAF1	oncoprotein	11	0.400	18.287	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
104	RFC2	interactor	7	0.714	2.405	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_16 (PF13191): AAA ATPase domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
105	RFC4	interactor	8	0.500	8.475	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
106	RUNX1	suppressor	15	0.549	16.011	Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
107	RUVBL1	oncoprotein	15	0.407	24.955	TIP49 (PF06068, IPR010339): TIP49 C-terminus
108	RXRA	oncoprotein	43	0.175	510.617	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
109	RXRB	interactor	4	0.833	0.500	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
110	RXRG	interactor	6	0.533	5.036	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
111	SAFB	suppressor	6	0.533	2.383	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
112	SAP130	interactor	4	1.000	0	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
113	SET	oncoprotein	8	0.571	2.460	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
114	SETD7	protein found in more fusions	7	0.667	1.637	MORN (PF02493, IPR003409, SM00698): MORN repeat MORN_2 (PF07661, IPR011652): MORN repeat variant SET (PF00856, IPR001214, SM00317): SET domain
115	SIAH1	suppressor	7	0.533	5.250	Sina (PF03145, IPR018121): Seven in absentia protein family
116	SIRT1	suppressor	25	0.304	92.500	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
117	SKI	oncoprotein	13	0.439	17.782	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
118	SMAD2	suppressor	23	0.364	65.736	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
119	SMARCD3	interactor	4	0.500	1.467	SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
120	SMURF1	interactor	9	0.500	4.777	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
121	SNRNP40	interactor	6	0.667	1.287	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
122	SNW1	protein found in more fusions	28	0.234	165.450	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
123	SP1	protein found in more fusions	24	0.447	57.403	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
124	SPI1	suppressor	7	0.667	2.989	Ets (PF00178, IPR000418, SM00413): Ets-domain p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
125	SQSTM1	oncoprotein	14	0.333	33.097	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
126	SRC	oncoprotein	12	0.400	15.135	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
127	SRF	interactor	13	0.591	11.253	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
128	SUMO2	interactor	15	0.363	35.338	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
129	SUV39H1	protein found in more fusions	14	0.385	26.519	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain
130	SUZ12	suppressor	16	0.410	35.158	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
131	TAB1	interactor	7	0.762	1.218	PP2C (PF00481, IPR001932): Protein phosphatase 2C
132	TADA3	interactor	4	0.833	0.200	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
133	TBL1XR1	oncoprotein	9	0.444	9.420	LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
134	TDG	interactor	6	0.733	0.928	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
135	TEKT4	interactor	2	1.000	0	Tektin (PF03148, IPR000435): Tektin family
136	TMEM54	interactor	3	0.667	0.143	BCLP (PF12304, IPR020977): Beta-casein like protein
137	TNIP1	interactor	7	0.400	3.519	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
138	TOP2B	oncoprotein	8	0.714	2.545	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DASH_Spc19 (PF08287, IPR013251): Spc19 DNA_gyraseB (PF00204, IPR013506): DNA gyrase B DTHCT (PF08070, IPR012542): DTHCT (NUC029) region HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim (PF01751, IPR006171, SM00493): Toprim domain Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
139	TRIM24	suppressor	5	0.833	0.222	PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Siva (PF05458, IPR022773): Cd27 binding protein (Siva) zf-MYND (PF01753, IPR002893): MYND finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 Imm68 (PF15583, IPR028276): Immunity protein 68 SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
140	TRIM32	suppressor	7	0.467	4.867	NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
141	TRIP4	interactor	9	0.556	6.589	ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
142	UBC	protein found in more fusions	27	0.234	167.791	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
143	UBE2M	interactor	8	0.381	3.633	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
144	UBE3A	oncoprotein	10	0.333	14.891	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
145	UBQLN1	protein found in more fusions	10	0.333	16.117	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
146	USP7	oncoprotein	12	0.418	17.848	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
147	WTIP	interactor	1	0	0	DUF983 (PF06170, IPR009325): Protein of unknown function (DUF983) LIM (PF00412, IPR001781, SM00132): LIM domain
148	WWOX	suppressor	6	0.533	2.611	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
149	XPO1	interactor	35	0.160	365.591	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
150	ZBTB16	suppressor	16	0.476	26.418	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	AGO2	interactor	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
2	AGO3	interactor	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3	AKAP1	interactor	TUDOR (PF00567, IPR002999, SM00333): Tudor domain RII_binding_1 (PF10522, IPR018459): RII binding domain KH_1 (PF00013, IPR004088, SM00322): KH domain
4	AKAP11	interactor	E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
5	AKAP3	interactor	AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110) RII_binding_1 (PF10522, IPR018459): RII binding domain
6	AKAP4	interactor	AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110) RII_binding_1 (PF10522, IPR018459): RII binding domain
7	ANKRD26	interactor	DUF1269 (PF06897, IPR009200): Protein of unknown function (DUF1269) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) FlxA (PF14282, IPR025577): FlxA-like protein CCDC144C (PF14915): CCDC144C protein coiled-coil region PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
8	ARFGEF1	interactor	DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
9	ARFGEF2	interactor	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
10	ARPC3	interactor	P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
11	BTRC	oncoprotein	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
12	C2orf88	interactor	SmAKAP (PF15127, IPR027969): Small membrane A-kinase anchor protein
13	CBS	interactor	CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
14	CUL7	interactor	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
15	GABARAPL1	interactor	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
16	GPR161	oncoprotein	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
17	IFI16	suppressor	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
18	MAPT	interactor	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
19	MCRS1	interactor	FHA (PF00498, IPR000253, SM00240): FHA domain MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
20	MEN1	suppressor	Menin (PF05053, IPR007747): Menin
21	NELL2	interactor	EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like TILa (PF12714, IPR025615): TILa domain EGF_3 (PF12947, IPR024731): EGF domain
22	NPRL2	suppressor	NPR2 (PF06218, IPR009348): Nitrogen permease regulator 2
23	PFDN5	interactor	Prefoldin (PF02996, IPR004127): Prefoldin subunit UPF0693 (PF16088, IPR032143): UPF0693 family
24	PRKAR1A	parental protein	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
25	PRKAR1B	interactor	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
26	PRPF31	interactor	Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
27	PYCARD	suppressor	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
28	RARA	parental protein	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
29	SLC2A4	interactor	Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
30	SLC38A5	interactor	Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
31	SOX2	oncoprotein	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
32	STOML2	oncoprotein	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769) Band_7_C (PF16200, IPR032435): C-terminal region of band_7
33	VAPA	interactor	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
34	WDCP	interactor	DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
35	WNK1	interactor	SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
36	ZBED1	interactor	Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region zf-BED (PF02892, IPR003656, SM00614): BED zinc finger DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)

B a c k t o T o p ⇑

Fusion ID: Protein names:	EF428111
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