1 |
EC448406 | chimera | 169 | 0.086 | 16230.005 | DUF572 (PF04502, IPR007590): Family of unknown function (DUF572) HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein PHD_2 (PF13831): PHD-finger zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain SOBP (PF15279, IPR026092): Sine oculis-binding protein SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2 |
2 |
ADRB2 | interactor | 14 | 0.333 | 28.053 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
3 |
AIRE | interactor | 9 | 0.321 | 6.072 | PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain |
4 |
AKT1 | oncoprotein | 24 | 0.344 | 79.510 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
5 |
APP | protein found in more fusions | 42 | 0.167 | 387.310 | APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
6 |
ARL8B | interactor | 3 | 0.667 | 0.154 | Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family |
7 |
ARMC6 | interactor | 4 | 0.667 | 0.376 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain |
8 |
ATF2 | oncoprotein | 9 | 0.500 | 6.821 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type |
9 |
ATXN3 | interactor | 8 | 0.571 | 3.015 | Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
10 |
AURKA | oncoprotein | 25 | 0.399 | 50.594 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
11 |
AURKB | interactor | 20 | 0.433 | 34.519 | Pkinase (PF00069, IPR000719): Protein kinase domain |
12 |
BRCA1 | suppressor | 21 | 0.363 | 46.092 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
13 |
BUB1B | oncoprotein | 10 | 0.528 | 4.138 | Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2 Pkinase (PF00069, IPR000719): Protein kinase domain XhlA (PF10779, IPR019715): Haemolysin XhlA CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 |
14 |
CAND1 | interactor | 30 | 0.552 | 37.817 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
15 |
CASK | interactor | 7 | 0.476 | 5.647 | L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase |
16 |
CBL | suppressor | 21 | 0.342 | 68.923 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
17 |
CDC20 | oncoprotein | 14 | 0.500 | 11.109 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
18 |
CDC37 | protein found in more fusions | 24 | 0.391 | 55.133 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
19 |
CDC5L | interactor | 40 | 0.321 | 200.691 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
20 |
CDK13 | interactor | 7 | 0.857 | 0.662 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family |
21 |
CDKN2A | suppressor | 17 | 0.500 | 20.634 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
22 |
CEBPE | interactor | 4 | 0.667 | 0.667 | Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper |
23 |
CEBPG | interactor | 5 | 0.500 | 2.167 | bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 |
24 |
CEP250 | interactor | 12 | 0.394 | 11.524 | ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
25 |
CEP44 | interactor | 4 | 0.500 | 2.667 | DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Utp12 (PF04003, IPR007148): Dip2/Utp12 Family CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44 |
26 |
CLIP1 | oncoprotein | 4 | 0.500 | 2.250 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain CP12 (PF02672, IPR003823, SM01093): CP12 domain DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) FliJ (PF02050, IPR012823): Flagellar FliJ protein Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain SlyX (PF04102, IPR007236): SlyX ApoO (PF09769, IPR019166): Apolipoprotein O Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Leu_zip (PF15294): Leucine zipper CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
27 |
CNN1 | suppressor | 2 | 1.000 | 0 | Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain |
28 |
COPB2 | interactor | 10 | 0.583 | 5.810 | Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
29 |
COPS5 | protein found in more fusions | 39 | 0.408 | 126.507 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
30 |
COPS6 | interactor | 18 | 0.684 | 9.776 | DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function |
31 |
CRK | oncoprotein | 15 | 0.457 | 21.303 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
32 |
CRX | interactor | 3 | 0.667 | 1.000 | TF_Otx (PF03529, IPR013851): Otx1 transcription factor Homeobox (PF00046, IPR001356, SM00389): Homeobox domain SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
33 |
CRY1 | interactor | 16 | 0.390 | 20.483 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
34 |
CRYZ | interactor | 1 | 0 | 0 | ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase |
35 |
CUL1 | suppressor | 40 | 0.417 | 120.743 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
36 |
CUL2 | suppressor | 28 | 0.455 | 62.514 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
37 |
CUL3 | protein found in more fusions | 51 | 0.339 | 282.301 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
38 |
CUL4A | protein found in more fusions | 25 | 0.449 | 57.552 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
39 |
CUL4B | oncoprotein | 20 | 0.642 | 11.539 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
40 |
CUL5 | suppressor | 20 | 0.763 | 6.421 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
41 |
DISC1 | interactor | 8 | 0.607 | 3.317 | HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding |
42 |
DOT1L | oncoprotein | 6 | 0.400 | 7.733 | AT_hook (PF02178, IPR017956, SM00384): AT hook motif DivIC (PF04977, IPR007060): Septum formation initiator DOT1 (PF08123, IPR013110): Histone methylation protein DOT1 ZapB (PF06005, IPR009252): Cell division protein ZapB HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV) |
43 |
EEF1A1 | suppressor | 55 | 0.207 | 567.890 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
44 |
EEF2 | interactor | 40 | 0.299 | 232.768 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
45 |
EIF5 | interactor | 10 | 0.622 | 5.106 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon |
46 |
ELAVL1 | oncoprotein | 44 | 0.220 | 417.127 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
47 |
EMD | interactor | 15 | 0.462 | 18.485 | LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
48 |
ENOX2 | interactor | 1 | 0 | 0 | ABC_tran (PF00005, IPR003439): ABC transporter bZIP_1 (PF00170, IPR004827): bZIP transcription factor RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TMCO5 (PF14992, IPR026617): TMCO5 family |
49 |
EPRS | interactor | 24 | 0.319 | 70.021 | GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain |
50 |
EPS15 | oncoprotein | 13 | 0.455 | 13.404 | Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
51 |
ERBB3 | oncoprotein | 15 | 0.363 | 33.480 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
52 |
ERG | oncoprotein | 8 | 0.607 | 2.163 | Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
53 |
ERLIN2 | interactor | 8 | 0.536 | 2.943 | Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346) |
54 |
ESR1 | suppressor | 37 | 0.303 | 178.002 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
55 |
ESRRB | suppressor | 9 | 0.583 | 4.952 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
56 |
FN1 | oncoprotein | 32 | 0.270 | 121.885 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
57 |
FNBP1 | oncoprotein | 3 | 1.000 | 0 | FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat Laminin_II (PF06009, IPR010307): Laminin Domain II DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) SH3_9 (PF14604, IPR001452): Variant SH3 domain T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB |
58 |
FUS | suppressor | 37 | 0.419 | 134.776 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
59 |
GAN | protein found in more fusions | 6 | 1.000 | 0 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif |
60 |
HAUS1 | interactor | 9 | 0.357 | 10.578 | THP2 (PF09432, IPR018557): Tho complex subunit THP2 XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496) |
61 |
HAUS2 | interactor | 4 | 0.833 | 0.333 | DpnII (PF04556, IPR007637): DpnII restriction endonuclease HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2 |
62 |
HDAC5 | protein found in more fusions | 28 | 0.299 | 88.720 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
63 |
HGS | interactor | 14 | 0.253 | 46.153 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo |
64 |
HSP90AA1 | oncoprotein | 65 | 0.251 | 672.320 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
65 |
HSP90AB1 | oncoprotein | 57 | 0.249 | 488.699 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
66 |
HSPA4 | interactor | 35 | 0.296 | 187.997 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
67 |
HTRA2 | suppressor | 6 | 0.700 | 0.702 | Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32 PDZ_2 (PF13180, IPR001478): PDZ domain Trypsin_2 (PF13365): Trypsin-like peptidase domain |
68 |
HTT | protein found in more fusions | 11 | 0.489 | 12.896 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
69 |
HUWE1 | oncoprotein | 38 | 0.294 | 194.861 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
70 |
ID2 | oncoprotein | 4 | 1.000 | 0 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain |
71 |
IGSF8 | oncoprotein | 5 | 0.600 | 3.400 | V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
72 |
IKBKG | interactor | 21 | 0.358 | 54.276 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
73 |
INPPL1 | oncoprotein | 11 | 0.709 | 3.491 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
74 |
KAT2A | interactor | 8 | 0.524 | 5.849 | Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family |
75 |
KIAA0368 | interactor | 10 | 0.356 | 15.063 | HEAT (PF02985, IPR000357): HEAT repeat IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) CLASP_N (PF12348, IPR024395): CLASP N terminal MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal Ecm29 (PF13001, IPR024372): Proteasome stabiliser HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
76 |
KRTAP10-8 | interactor | 5 | 0.667 | 2.000 | Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein PMG (PF05287, IPR007951): PMG protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein |
77 |
LAMP2 | protein found in more fusions | 6 | 0.500 | 0.841 | Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) |
78 |
LGR4 | interactor | 8 | 0.381 | 4.820 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
79 |
LNX2 | interactor | 2 | 0 | 0 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DZR (PF12773, IPR025874): Double zinc ribbon zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
80 |
LRRK2 | oncoprotein | 15 | 0.473 | 15.195 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
81 |
MAGEA2B | interactor | 1 | 0 | 0 | MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal |
82 |
MAGED2 | interactor | 12 | 0.545 | 10.943 | CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 MAGE (PF01454, IPR002190): MAGE family SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) |
83 |
MAP1LC3A | interactor | 8 | 0.429 | 8.850 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
84 |
MAPK7 | oncoprotein | 14 | 0.590 | 11.266 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
85 |
MAPRE1 | oncoprotein | 18 | 0.338 | 45.841 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
86 |
MARK4 | oncoprotein | 3 | 0.667 | 0.400 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
87 |
MDM2 | oncoprotein | 32 | 0.331 | 137.873 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
88 |
MED15 | interactor | 1 | 0 | 0 | Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal |
89 |
MEOX2 | interactor | 6 | 0.400 | 7.015 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
90 |
MID1 | oncoprotein | 7 | 0.467 | 3.473 | Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SPRY (PF00622, IPR003877, SM00449): SPRY domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
91 |
MLLT1 | oncoprotein | 2 | 1.000 | 0 | DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DDRGK (PF09756, IPR019153, SM01128): DDRGK domain |
92 |
MYC | oncoprotein | 30 | 0.288 | 126.474 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
93 |
NANOG | interactor | 10 | 0.222 | 16.562 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
94 |
NCAM1 | interactor | 2 | 1.000 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Syndecan (PF01034, IPR027789): Syndecan domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
95 |
NCAPH2 | interactor | 4 | 0.667 | 0.077 | CNDH2_N (PF06278, IPR009378): Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_C (PF16858, IPR031737): Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_M (PF16869): PF16858 |
96 |
NEDD1 | interactor | 5 | 0.500 | 3.733 | NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A FliM (PF02154, IPR001689): Flagellar motor switch protein FliM WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
97 |
NEDD8 | interactor | 21 | 0.500 | 39.201 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
98 |
NOP56 | interactor | 14 | 0.560 | 12.680 | Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal |
99 |
NPHP1 | interactor | 4 | 0.667 | 0.500 | SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FAM176 (PF14851): FAM176 family Speriolin_N (PF15058, IPR029385): Speriolin N terminus DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) |
100 |
NTRK1 | oncoprotein | 68 | 0.207 | 932.121 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
101 |
OLA1 | interactor | 9 | 0.556 | 3.262 | Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933) |
102 |
PARK2 | suppressor | 31 | 0.244 | 192.166 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
103 |
PARP1 | suppressor | 25 | 0.279 | 90.496 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
104 |
PEX14 | protein found in more fusions | 2 | 0 | 0 | HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation |
105 |
PHB2 | interactor | 17 | 0.213 | 36.055 | DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family |
106 |
PIK3R2 | oncoprotein | 18 | 0.458 | 31.412 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
107 |
PINK1 | protein found in more fusions | 10 | 0.583 | 6.651 | Pkinase (PF00069, IPR000719): Protein kinase domain |
108 |
PKN1 | interactor | 7 | 0.667 | 1.839 | C2 (PF00168, IPR000008, SM00239): C2 domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
109 |
POLH | oncoprotein | 7 | 0.619 | 4.026 | IMS (PF00817, IPR001126): impB/mucB/samB family IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein |
110 |
POU5F1 | oncoprotein | 15 | 0.253 | 34.089 | Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
111 |
PPID | interactor | 9 | 0.583 | 2.501 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat |
112 |
PPP1CC | oncoprotein | 18 | 0.458 | 24.355 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
113 |
PSMC5 | protein found in more fusions | 22 | 0.319 | 49.483 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain |
114 |
PSTPIP1 | interactor | 1 | 0 | 0 | ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 |
115 |
RAB8B | oncoprotein | 5 | 0.500 | 2.486 | Ras (PF00071, IPR001806, SM00173): Ras family |
116 |
RANBP2 | oncoprotein | 15 | 0.407 | 22.019 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
117 |
RARS | interactor | 12 | 0.455 | 7.268 | Arg_tRNA_synt_N (PF03485, IPR005148, SM01016): Arginyl tRNA synthetase N terminal domain DALR_1 (PF05746, IPR008909, SM00836): DALR anticodon binding domain DivIC (PF04977, IPR007060): Septum formation initiator tRNA-synt_1d (PF00750, IPR015945): tRNA synthetases class I (R) Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region |
118 |
RASSF1 | suppressor | 11 | 0.533 | 5.550 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain |
119 |
RNF146 | interactor | 5 | 0.500 | 1.667 | WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
120 |
RPA1 | suppressor | 20 | 0.567 | 14.741 | Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain |
121 |
RPA2 | oncoprotein | 20 | 0.511 | 19.676 | RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2 |
122 |
RPA3 | interactor | 17 | 0.583 | 10.764 | Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3 |
123 |
RPL10 | suppressor | 17 | 0.368 | 24.550 | Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e |
124 |
RPS6KB2 | interactor | 11 | 0.527 | 9.615 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
125 |
RUFY1 | interactor | 4 | 1.000 | 0 | DM (PF00751, IPR001275, SM00301): DM DNA binding domain FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger RUN (PF02759, IPR004012, SM00593): RUN domain Tektin (PF03148, IPR000435): Tektin family |
126 |
SF3B3 | interactor | 28 | 0.384 | 104.654 | CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term |
127 |
SHC1 | oncoprotein | 16 | 0.524 | 16.158 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
128 |
SKI | oncoprotein | 7 | 0.733 | 0.776 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
129 |
SMC3 | oncoprotein | 20 | 0.358 | 54.117 | SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain |
130 |
SMURF1 | interactor | 14 | 0.551 | 7.390 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
131 |
SNW1 | protein found in more fusions | 31 | 0.407 | 89.064 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
132 |
SPP1 | oncoprotein | 7 | 0.476 | 7.188 | Osteopontin (PF00865, IPR002038, SM00017): Osteopontin |
133 |
SPRY2 | suppressor | 8 | 0.429 | 9.067 | KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9 Sprouty (PF05210, IPR007875): Sprouty protein (Spry) |
134 |
STAU1 | protein found in more fusions | 24 | 0.399 | 50.340 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
135 |
STK24 | interactor | 7 | 0.533 | 2.282 | DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain |
136 |
SUMO2 | interactor | 9 | 0.429 | 7.236 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
137 |
SYK | suppressor | 11 | 0.378 | 13.946 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
138 |
SYT9 | interactor | 1 | 0 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain |
139 |
TAOK2 | interactor | 2 | 1.000 | 0 | Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated Pkinase (PF00069, IPR000719): Protein kinase domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term |
140 |
TARDBP | interactor | 28 | 0.427 | 55.704 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
141 |
TBC1D3 | interactor | 1 | 0 | 0 | RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain |
142 |
TCF12 | oncoprotein | 8 | 0.667 | 5.233 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain |
143 |
TCF4 | suppressor | 8 | 0.321 | 11.414 | CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain |
144 |
TJP1 | interactor | 6 | 0.667 | 3.487 | DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal |
145 |
TNPO2 | interactor | 5 | 0.700 | 0.690 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Dopey_N (PF04118, IPR007249): Dopey, N-terminal IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain DUF2573 (PF10835, IPR020393): Protein of unknown function (DUF2573) DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
146 |
TP53 | suppressor | 41 | 0.274 | 246.015 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
147 |
TRAF3IP1 | interactor | 8 | 0.536 | 3.576 | MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 |
148 |
TRIM29 | protein found in more fusions | 8 | 0.381 | 6.988 | MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger |
149 |
TSGA10 | interactor | 4 | 0.667 | 1.000 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
150 |
U2AF2 | protein found in more fusions | 29 | 0.508 | 40.594 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
151 |
UBASH3B | interactor | 15 | 0.440 | 23.837 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain |
152 |
UBE2G2 | interactor | 7 | 0.333 | 5.419 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
153 |
UBL4A | interactor | 20 | 0.316 | 60.079 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
154 |
UBQLN1 | protein found in more fusions | 15 | 0.374 | 28.280 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X |
155 |
UBQLN4 | interactor | 10 | 0.333 | 19.533 | CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain |
156 |
UNK | interactor | 22 | 0.338 | 45.122 | MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain |
157 |
VAV1 | oncoprotein | 6 | 0.600 | 3.352 | PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain |
158 |
VCAM1 | interactor | 25 | 0.270 | 68.591 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
159 |
VCP | protein found in more fusions | 45 | 0.311 | 265.795 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
160 |
WHSC1L1 | suppressor | 5 | 0.500 | 2.498 | PHD (PF00628, IPR019787, SM00249): PHD-finger Presenilin (PF01080, IPR001108): Presenilin PWWP (PF00855, IPR000313, SM00293): PWWP domain SET (PF00856, IPR001214, SM00317): SET domain zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2 |
161 |
XPO1 | interactor | 49 | 0.180 | 610.513 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
162 |
YBX1 | oncoprotein | 29 | 0.360 | 87.853 | CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2 |
163 |
YEATS4 | interactor | 7 | 0.333 | 8.474 | YEATS (PF03366, IPR005033): YEATS family SOGA (PF11365, IPR027881): Protein SOGA |
164 |
YWHAB | interactor | 23 | 0.411 | 47.780 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
165 |
YWHAE | oncoprotein | 32 | 0.363 | 89.193 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
166 |
YWHAQ | interactor | 33 | 0.316 | 136.009 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
167 |
YWHAZ | protein found in more fusions | 34 | 0.348 | 101.319 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
168 |
ZAP70 | interactor | 9 | 0.607 | 4.508 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
169 |
ZBTB1 | interactor | 3 | 0.667 | 0.500 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |
170 |
ZBTB22 | interactor | 2 | 1.000 | 0 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256) Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |