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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DR423509 is the fusion of parental proteins VANGL1, PARP12 (from a repository: Fri Jan 13 04:04:24 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins5 (45.45 %)
The number (and %) of the tumor suppressors2 (18.18 %)
Total number of binary PPIs (saturation %)29 (52.73 %)
The number (and %) of affected PPIs10 (34.48 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.182
Assortativity coefficient-0.5121
The network average Clustering coefficient0.663
The number (and %) of a zero Clustering coefficients2 (18.18 %)
The number (and %) of a zero Betweenness Centrality7 (63.64 %)


List of the fusions

PPI for parental proteins: VANGL1,PARP12 All fusions
: DR423509;
Proteins found in more fusions BCL6 (see 2 fusions); RPA1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 DR423509chimera100.28952.000PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
WWE (PF02825, IPR004170, SM00678): WWE domain
2 BCL6oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
3 CBX2interactor31.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
CBX7_C (PF17218): CBX family C-terminal motif
4 CBX4oncoprotein41.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
5 ELAVL1oncoprotein70.6674.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 MLH1suppressor100DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
7 RNF2interactor70.5336.667zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
8 RPA1suppressor60.8001.333Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
9 RPA2oncoprotein41.0000RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
10 RPA3interactor51.0000Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
11 XPO1interactor31.0000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CCDC8interactorBorrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
2 EPB41L3suppressor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
3 EVC2interactorHBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
4 FBXW11interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 GMFGinteractorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
6 KBTBD7interactorBACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
7 KRASoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
8 LUC7LinteractorLUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
9 NAF1interactorAF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
10 NT5C3AinteractorUMPH-1 (PF05822, IPR006434): Pyrimidine 5'-nucleotidase (UMPH-1)
DUF3180 (PF11377, IPR021517): Protein of unknown function (DUF3180)
11 PARP12parental proteinPARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
WWE (PF02825, IPR004170, SM00678): WWE domain
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
12 RAPGEF5interactorDEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
13 RASSF10suppressorDUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
14 RASSF9interactorRA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
DUF3087 (PF11286, IPR021438): Protein of unknown function (DUF3087)
15 SMYD3oncoproteinSET (PF00856, IPR001214, SM00317): SET domain
16 SPRY2suppressorKAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
17 SRPK1interactorFYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
18 TCTN3interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
19 THAP2interactorTHAP (PF05485, IPR006612, SM00980): THAP domain
20 TMEM17interactorTransmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
21 TMEM216interactorTransmemb_17 (PF09799, IPR019184): Predicted membrane protein
22 VANGL1parental proteinStrabismus (PF06638, IPR009539): Strabismus protein
23 ZRANB2interactorRRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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