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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: DL057417 is the fusion of parental proteins SIAH1 (from a repository: Mon Dec 26 05:29:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)150
The number (and %) of the onco-proteins45 (30.00 %)
The number (and %) of the tumor suppressors20 (13.33 %)
Total number of binary PPIs (saturation %)513 (4.59 %)
The number (and %) of affected PPIs149 (29.04 %)
The number of possible different fusions35
PPI diameter2
PPI radius1
The average degree of PPI5.893
Assortativity coefficient-0.4015
The network average Clustering coefficient0.485
The number (and %) of a zero Clustering coefficients33 (22.00 %)
The number (and %) of a zero Betweenness Centrality66 (44.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SIAH1 All fusions
: DL057417;
Proteins found in more fusions AFF1 (see 2 fusions); RARA/PML (see 21 fusions); PUF60 (see 2 fusions); PKD1 (see 1 fusions); HIPK2 (see 1 fusions); NPM1 (see 1 fusions); BCL6 (see 2 fusions); RBBP8 (see 1 fusions); UBE2N (see 1 fusions); EEF1D (see 3 fusions); PIAS2 (see 2 fusions); RUNX1 (see 1 fusions); STAT3 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2L6 (see 2 fusions); SH3RF1 (see 1 fusions); UBE2E2 (see 1 fusions); RARA/NPM1 (see 1 fusions); PIAS1 (see 2 fusions); SNCAIP (see 1 fusions); RARA (see 4 fusions); MCM2 (see 1 fusions); APC (see 1 fusions); HTT (see 1 fusions); COPS5 (see 1 fusions); SIAH2 (see 1 fusions); ATN1 (see 1 fusions); PFKM (see 1 fusions); PYGB (see 1 fusions); MAP3K5 (see 1 fusions); PML (see 4 fusions); TBL1X (see 2 fusions); PSMC5 (see 2 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DL057417chimera1490.02719420.418Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
2 AASDHPPTinteractor21.0000ACPS (PF01648, IPR008278): 4'-phosphopantetheinyl transferase superfamily
3 AFF1oncoprotein60.5004.400AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4 AFF4oncoprotein31.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
5 APCsuppressor60.6003.000APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
6 AQP1interactor40.6671.000MIP (PF00230, IPR000425): Major intrinsic protein
7 ARMC9interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
AP3D1 (PF06375): AP-3 complex subunit delta-1
8 ATN1protein found in more fusions60.4004.000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
9 ATXN7interactor80.46412.067DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
10 BAG1oncoprotein60.4008.333BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
11 BCL6oncoprotein60.5004.667BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
12 C14orf105interactor21.0000DUF4619 (PF15398, IPR029235): Domain of unknown function (DUF4619)
13 CACYBPinteractor60.6003.000CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
14 CAPGsuppressor100Gelsolin (PF00626, IPR007123): Gelsolin repeat
15 CDC23interactor31.0000ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
16 CDC34oncoprotein40.6671.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
17 CDK5R1oncoprotein21.0000CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
18 COPS5protein found in more fusions130.22745.000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
19 CTNNB1oncoprotein140.23163.452Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
20 DAB1interactor40.6672.000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
21 DCCsuppressor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
22 DDX41interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
zf-CCHC (PF00098, IPR001878): Zinc knuckle
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DLDinteractor21.0000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
24 DNAJC15interactor200DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3918 (PF13056, IPR025029): Protein of unknown function (DUF3918)
25 DNALI1interactor31.0000Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
26 EEF1Dprotein found in more fusions70.4674.936EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
27 ELL2interactor31.0000Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
28 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
29 FLI1oncoprotein41.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
30 FLT3suppressor31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
31 FZD9interactor100Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region
Fz (PF01392, IPR020067, SM00063): Fz domain
32 GAPDHoncoprotein100.38917.286Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
33 GDPD5interactor100DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
MgtE (PF01769, IPR006667): Divalent cation transporter
GDPD_2 (PF13653): Glycerophosphoryl diester phosphodiesterase family
34 GRM5interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
35 HERPUD1oncoprotein50.5004.333Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
36 HIPK1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
37 HIPK2suppressor60.8001.167Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
38 HIPK3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
39 HIST4H4interactor40.5001.536CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
40 HTTprotein found in more fusions100.27820.667HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
41 INHAoncoprotein100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
42 JSRP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
43 KATNAL1interactor200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_24 (PF13479): AAA domain
44 KCNJ10interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
45 KHDRBS3interactor31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
46 KIAA0319Linteractor100EGF_2 (PF07974, IPR013111): EGF-like domain
PKD (PF00801, IPR000601, SM00089): PKD domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
DUF4625 (PF15418, IPR027829): Domain of unknown function (DUF4625)
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
47 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
48 KIAA1683interactor30.6670.500IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
49 KIF1Bsuppressor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
KIF1B (PF12423, IPR022140): Kinesin protein 1B
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
DUF3694 (PF12473, IPR022164): Kinesin protein
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
50 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
51 KIFC3oncoprotein60.5004.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
52 KLF10suppressor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
AAA_33 (PF13671): AAA domain
53 LACTB2interactor100E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
54 LATS2suppressor70.5335.167Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
55 MAP3K5oncoprotein50.6671.167Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
56 MAPK12oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
57 MAPKBP1interactor21.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
58 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
59 MCM2oncoprotein170.23369.039AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
60 MTIF3interactor100IF3_C (PF00707, IPR019815): Translation initiation factor IF-3, C-terminal domain
IF3_N (PF05198, IPR019814): Translation initiation factor IF-3, N-terminal domain
61 MX1interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
62 MYD88oncoprotein40.6670.500Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
63 NECTIN2interactor200C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
64 NELFAinteractor100CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
65 NOL6interactor40.5001.667Nrap (PF03813, IPR005554): Nrap protein
66 NPM1suppressor130.30338.619Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
67 NUMBsuppressor21.0000NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
68 NUMBLinteractor100DUF1932 (PF09130, IPR015814): Domain of unknown function (DUF1932)
NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
69 OPRD1interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
70 OPRK1interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
71 OPRM1interactor40.6671.6677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
DMRT-like (PF15791, IPR031577): Doublesex-and mab-3-related transcription factor C1 and C2
72 OTUB2interactor50.5003.250Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
73 PARD3interactor40.8330.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
74 PEG10oncoprotein60.3338.952CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
Asp_protease_2 (PF13650): Aspartyl protease
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
PRIMA1 (PF16101): Proline-rich membrane anchor 1
DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
75 PEG3suppressor31.0000C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_10 (PF13237, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-Mss51 (PF13824, IPR032717): Zinc-finger of mitochondrial splicing suppressor 51
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
76 PFKMprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
77 PHC1interactor60.6003.000GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
FSA_C (PF10479, IPR018863): Fragile site-associated protein C-terminus
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
78 PHC2interactor90.28615.417SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
79 PIAS1suppressor130.42424.167Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
80 PIAS2protein found in more fusions100.6117.433SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
81 PIAS3oncoprotein60.5333.450SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
82 PKD1suppressor31.0000Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
83 PLCE1suppressor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
84 PMLsuppressor150.34146.667zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
85 POU2AF1oncoprotein100PD-C2-AF1 (PF09310, IPR015389): POU domain, class 2, associating factor 1
86 PRPF31interactor80.28612.667Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
87 PSMC5protein found in more fusions80.38111.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
88 PSMC6interactor50.6671.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
89 PTPMT1interactor40.6670.667DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
90 PUF60protein found in more fusions80.28612.452RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
91 PYGBprotein found in more fusions41.0000Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
92 QRICH1interactor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
93 RAB33Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
94 RAD51AP1interactor100RAD51_interact (PF15696, IPR031419): RAD51 interacting motif
95 RAD54L2interactor40.6671.000SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
96 RAPH1oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
FAM76 (PF16046, IPR032017): FAM76 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
97 RARAoncoprotein70.5335.833zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
98 RBBP8suppressor40.6671.000ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
99 RLIMinteractor80.3335.972DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
100 RNF2interactor200.164115.972zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
101 RPS19BP1interactor21.0000AROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
102 RUNX1suppressor60.6002.833Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
103 SDCBPinteractor80.25019.167PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
104 SEPT4suppressor30.6671.000Septin (PF00735, IPR000038): Septin
105 SH3RF1protein found in more fusions70.4675.682zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
106 SIAH2oncoprotein350.100471.434Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
107 SNCAinteractor70.4677.000Synuclein (PF01387, IPR001058): Synuclein
108 SNCAIPprotein found in more fusions50.8330.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
109 SPATA4interactor100CH_2 (PF06294, IPR010441): CH-like domain in sperm protein
110 SPATC1Linteractor30.6670.333Speriolin_N (PF15058, IPR029385): Speriolin N terminus
Speriolin_C (PF15059, IPR029384): Speriolin C-terminus
111 STAT3suppressor60.6002.567SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
112 SYT7interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
SCIMP (PF15050, IPR028181): SCIMP protein
113 TBC1D22Binteractor40.6671.000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
114 TBL1Xprotein found in more fusions80.4299.286K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
115 TERF2interactor60.5004.000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
116 TFDP1oncoprotein30.6670.500DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
117 TMEM43interactor100TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
118 TNK2interactor40.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
119 TOLLIPinteractor80.38111.952C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
120 TP53BP2suppressor80.28616.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
121 TRIB3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
122 TRIM23interactor150.29746.368Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
123 TRIM27oncoprotein340.121402.558IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
124 TRIM7oncoprotein50.6670.382IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
TMPIT (PF07851, IPR012926): TMPIT-like protein
YojJ (PF10372, IPR019457): Bacterial membrane-spanning protein N-terminus
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
125 TRIM8interactor100.38910.539dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
126 TXNoncoprotein90.44416.119Thioredoxin (PF00085, IPR013766): Thioredoxin
127 UBE2D1interactor150.31934.774UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
128 UBE2D2oncoprotein160.34342.726UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
129 UBE2D3interactor120.27316.940UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
130 UBE2D4interactor80.3814.102UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
131 UBE2E2protein found in more fusions70.4672.469UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
132 UBE2E3interactor60.5002.900UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
133 UBE2Iinteractor260.187206.519UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
134 UBE2Kinteractor80.5009.067UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
135 UBE2L6protein found in more fusions90.32112.436UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
136 UBE2Nprotein found in more fusions80.4298.367UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
137 UBE2V2interactor40.6670.750UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138 UPP2interactor200PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
139 USP19interactor50.4003.155CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
140 VAV1oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
141 WDYHV1interactor60.4676.867Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
142 XIAPinteractor160.21956.891BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
143 ZBP1interactor100z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
144 ZCCHC10interactor30.6671.000Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
145 ZCCHC13interactor100DUF1815 (PF08844, IPR014943): Domain of unknown function (DUF1815)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
146 ZFYVE21interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
ZFYVE21_C (PF16696, IPR032031): Zinc finger FYVE domain-containing protein 21 C-terminus
147 ZMAT3interactor100zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
148 ZNF148interactor100DUF680 (PF05079, IPR007771): Protein of unknown function (DUF680)
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
149 ZNF512Binteractor30.6671.000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
150 ZNF671interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EXOC3-AS1interactorNA
2 HIF1ANinteractorCupin_8 (PF13621): Cupin-like domain
3 MAB21L1interactorMab-21 (PF03281, IPR024810): Mab-21 protein
4 MOB3CinteractorMob1_phocein (PF03637, IPR005301): Mob1/phocein family
5 PRR20AinteractorPRR20 (PF15708, IPR031439): Proline-rich protein family 20
6 RPL27AinteractorRibosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
7 SIAH1parental proteinSina (PF03145, IPR018121): Seven in absentia protein family
8 SYPinteractorMARVEL (PF01284, IPR008253): Membrane-associating domain
9 UXTinteractorPrefoldin (PF02996, IPR004127): Prefoldin subunit

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