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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DL056055 is the fusion of parental proteins HMG20A (from a repository: Sun Dec 25 05:49:42 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins13 (23.64 %)
The number (and %) of the tumor suppressors8 (14.55 %)
Total number of binary PPIs (saturation %)204 (13.74 %)
The number (and %) of affected PPIs54 (26.47 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI6.800
Assortativity coefficient-0.4186
The network average Clustering coefficient0.511
The number (and %) of a zero Clustering coefficients16 (29.09 %)
The number (and %) of a zero Betweenness Centrality24 (43.64 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: HMG20A All fusions
: DL056055;
Proteins found in more fusions KDM1A (see 2 fusions); FMNL1 (see 1 fusions); GSE1 (see 1 fusions); SMAD4 (see 2 fusions); MBD2 (see 1 fusions); RCOR1 (see 2 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DL056055chimera540.0932229.187DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
2 ADD1interactor21.0000Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
3 BCORoncoprotein60.7001.667Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
4 BRAPinteractor200BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
5 CCDC136suppressor30.6670.400Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Sec34 (PF04136, IPR007265): Sec34-like family
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
FlxA (PF14282, IPR025577): FlxA-like protein
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
6 CCNKinteractor31.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
7 CDK2AP1suppressor150.53333.467CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
8 CFAP53interactor100Rsc14 (PF08586, IPR013895): RSC complex, Rsc14/Ldb7 subunit
YtxH (PF12732, IPR024623): YtxH-like protein
TPH (PF13868): Trichohyalin-plectin-homology domain
9 DOK4interactor60.7331.094IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
10 DTNBinteractor200EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
SOGA (PF11365, IPR027881): Protein SOGA
11 ELAVL1oncoprotein130.45526.119RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 FGF1oncoprotein60.8000.444FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
13 FMNL1protein found in more fusions200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
14 GATAD2Ainteractor110.8732.067DUF2299 (PF10061, IPR018747): Uncharacterized conserved protein (DUF2299)
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
15 GATAD2Binteractor110.8552.711DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
16 GSE1oncoprotein120.6916.489CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DUF3736 (PF12540, IPR022207): Protein of unknown function (DUF3736)
AAA_11 (PF13086): AAA domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
17 GTF2A1Linteractor100TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
18 HDAC1suppressor250.362125.482FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
19 HDAC2suppressor200.49747.176Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
20 HECW2interactor60.5004.667C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
21 HEMGNinteractor100BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
22 HIST1H2BAinteractor50.8000.622Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
23 HMG20Binteractor110.7099.980IncA (PF04156, IPR007285): IncA protein
NEMP (PF10225, IPR019358): NEMP family
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
24 HP1BP3interactor21.0000RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
25 HPCAL1interactor100DUF2554 (PF10829, IPR020117): Protein of unknown function (DUF2554)
26 HSPD1suppressor40.6671.500Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
27 HTTprotein found in more fusions200HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
28 KDM1Aprotein found in more fusions160.58120.580Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
29 KPNA2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
30 MAGOHBinteractor100Mago_nashi (PF02792, IPR004023): Mago nashi protein
31 MBD2oncoprotein120.8183.624API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
32 MOV10interactor40.5001.733AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
33 MTA2interactor120.8183.574BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
34 MTA3oncoprotein160.63317.252BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
35 PAWRsuppressor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
36 PHF14interactor60.6673.233Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
C1_2 (PF03107, IPR004146): C1 domain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
LicD (PF04991, IPR007074): LicD family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Rrp15p (PF07890, IPR012459): Rrp15p
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
37 PHF21Ainteractor70.8101.206AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
PHD (PF00628, IPR019787, SM00249): PHD-finger
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
38 PTH2Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
39 RAD51interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
40 RAI1interactor50.5004.667Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
41 RBBP7suppressor110.8911.702WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
42 RBM7interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43 RCOR1protein found in more fusions110.6446.302DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
44 RCOR3interactor120.60612.722ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
45 RPP30interactor100RNase_P_p30 (PF01876, IPR002738): RNase P subunit p30
46 RSPH9interactor21.0000Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein
47 SCNM1interactor21.0000zf-SCNM1 (PF15803, IPR031622): Zinc-finger of sodium channel modifier 1
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
48 SHMT2interactor30.6671.000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
49 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
50 SNAI1oncoprotein80.9290.444zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
51 SYTL4interactor100AreA_N (PF07573, IPR011420): Nitrogen regulatory protein AreA N terminus
C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
52 TCF20interactor120.59115.267tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
53 TESCinteractor21.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
54 TRIM27oncoprotein90.5009.622IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
55 UHRF1BP1interactor100Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 HMG20Aparental proteinDUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box

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