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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: DB502399 is the fusion of parental proteins OSTM1, PROSC (from a repository: Sun Mar 12 02:46:55 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins16 (28.07 %)
The number (and %) of the tumor suppressors1 (1.75 %)
Total number of binary PPIs (saturation %)225 (14.10 %)
The number (and %) of affected PPIs56 (24.89 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI7.404
Assortativity coefficient-0.4058
The network average Clustering coefficient0.534
The number (and %) of a zero Clustering coefficients11 (19.30 %)
The number (and %) of a zero Betweenness Centrality19 (33.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: OSTM1,PROSC All fusions
: DB502399;
Proteins found in more fusions NDUFS3 (see 1 fusions); DDX17 (see 3 fusions); RPA1 (see 1 fusions); MCM2 (see 1 fusions); NAGK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB502399chimera560.1012305.701Ala_racemase_N (PF01168, IPR001608): Alanine racemase, N-terminal domain
2 ADI1interactor100ARD (PF03079, IPR004313): ARD/ARD' family
3 AHSA1interactor70.4299.500Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4 ANAPC15interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
5 ARFIP1interactor21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
6 ASB6interactor50.7001.086Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
7 ASNSoncoprotein130.61522.129Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
8 ATIConcoprotein110.60010.321AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
9 CAPN2interactor160.36755.448Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
10 CAPNS1interactor100.8891.355EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CARSoncoprotein30.6670.667tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
12 CDK5R1oncoprotein100CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
13 CHORDC1interactor70.4676.900CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
14 DDX17protein found in more fusions80.6675.567CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 EIF4Eoncoprotein21.0000IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
16 ELAVL1oncoprotein150.31953.600RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17 ENSAinteractor100Endosulfine (PF04667, IPR006760): cAMP-regulated phosphoprotein/endosulfine conserved region
18 FCGR2Ainteractor100DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
19 GRK2interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
20 GSRinteractor50.6671.067Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
21 GTF3C4interactor41.0000TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
22 HEXBinteractor60.7001.952Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
23 HK1interactor70.6674.900Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
24 HNRNPA1interactor130.33336.700RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
25 HNRNPA3oncoprotein51.0000IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
26 ISOC1interactor140.63714.467Isochorismatase (PF00857, IPR000868): Isochorismatase family
Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
27 MCM2oncoprotein130.34836.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
28 MCTS1interactor110.56411.255DUF1947 (PF09183, IPR015266): Domain of unknown function (DUF1947)
PUA (PF01472, IPR002478, SM00359): PUA domain
29 MYO1Einteractor110.6919.448IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 NAE1interactor90.6116.910ThiF (PF00899, IPR000594): ThiF family
31 NAGKprotein found in more fusions41.0000BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
32 NDUFS3protein found in more fusions200Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
33 NME4interactor200NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
34 OGFOD1interactor140.63715.689Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term
2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily
35 OXNAD1interactor100NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
36 PAFAH1B2oncoprotein60.6674.286Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
37 PAPOLAinteractor40.6672.000PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
38 PARD6Binteractor21.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
39 PCK2interactor100PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
40 PDIA4interactor180.48446.533Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
41 PHGDHinteractor40.6671.1672-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
42 PHPT1interactor100Ocnus (PF05005, IPR007702): Janus/Ocnus family (Ocnus)
43 PPP1R2interactor80.6076.086IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
44 PRCPinteractor50.9000.500Peptidase_S28 (PF05577, IPR008758): Serine carboxypeptidase S28
45 PTMAoncoprotein130.6679.508Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
46 RPA1suppressor90.5718.233Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
47 SBDSoncoprotein30.6670.667SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
48 SMSinteractor40.6672.000Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
49 SOX2oncoprotein31.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
50 STK26interactor160.64813.982DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
51 SUMO3interactor100Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
52 TATDN1interactor100.46717.156TatD_DNase (PF01026, IPR001130): TatD related DNase
53 TBCBinteractor110.8183.093CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
54 TUFMinteractor110.43623.500GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
55 TWF2interactor100.6448.043Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
56 UBXN1interactor100.52811.586Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
57 YARSinteractor30.6671.000tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATP6AP2interactorPhosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
2 BIRC7interactorBIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
3 FAM177A1interactorRibosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
4 GPSM1interactorGoLoco (PF02188, IPR003109, SM00390): GoLoco motif
TPR_12 (PF13424): Tetratricopeptide repeat
5 LGALS3oncoproteinGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
6 LGALS8interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
7 LGALS9interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
8 LIG4interactorAPG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
9 MYEF2interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 OSTM1parental proteinOSTMP1 (PF09777, IPR019172): Osteopetrosis-associated transmembrane protein 1 precursor
11 PROSCparental proteinAla_racemase_N (PF01168, IPR001608): Alanine racemase, N-terminal domain
12 RGS17interactorRGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
13 RGS19oncoproteinRGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
14 RGS20interactorRGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
15 SLC25A32interactorMito_carr (PF00153, IPR018108): Mitochondrial carrier protein
16 YWHAEoncoprotein14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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