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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: DB443041 is the fusion of parental proteins SPDYA, BIRC5 (from a repository: Thu Feb 8 08:25:55 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins14 (42.42 %)
The number (and %) of the tumor suppressors7 (21.21 %)
Total number of binary PPIs (saturation %)121 (22.92 %)
The number (and %) of affected PPIs32 (26.45 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI6.303
Assortativity coefficient-0.2575
The network average Clustering coefficient0.598
The number (and %) of a zero Clustering coefficients4 (12.12 %)
The number (and %) of a zero Betweenness Centrality10 (30.30 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SPDYA,BIRC5 All fusions
: DB443041;
Proteins found in more fusions USF2 (see 1 fusions); HSP90AA1 (see 2 fusions); PRKDC (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB443041chimera320.145682.067BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
2 AIPsuppressor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
3 AURKAoncoprotein100.52812.067Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
4 AURKBinteractor100.52811.733Pkinase (PF00069, IPR000719): Protein kinase domain
5 AURKCinteractor40.8330.500Pkinase (PF00069, IPR000719): Protein kinase domain
6 BECN1suppressor70.6004.067APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
7 BIRC2oncoprotein90.7144.833BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 BIRC3oncoprotein90.7144.833BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 CASP3interactor110.48921.833Peptidase_C14 (PF00656, IPR011600): Caspase domain
10 CASP7interactor71.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
11 CASP9oncoprotein61.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CDCA8interactor50.8330.500Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
13 CDK2suppressor80.4299.333Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
14 CDK4oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
15 DIABLOsuppressor51.0000Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
16 EVI5interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
17 F2RL1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
18 FBXL7oncoprotein100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
19 H2AFXsuppressor50.7001.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
20 HDAC6oncoprotein80.5716.000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
21 HSP90AA1oncoprotein140.32144.233HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
22 INCENPinteractor60.6003.667ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
INCENP_ARK-bind (PF03941, IPR005635): Inner centromere protein, ARK binding region
INCENP_N (PF12178, IPR022006): Chromosome passenger complex (CPC) protein INCENP N terminal
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
23 MDC1suppressor40.8330.667FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
24 PARK2suppressor70.6003.667IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 PPP1CConcoprotein40.6671.167Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
26 PRKDCprotein found in more fusions90.5717.167FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
27 RANoncoprotein30.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
28 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
29 USF2protein found in more fusions200DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
30 USP9Xinteractor60.6006.000DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
31 XIAPinteractor80.8571.500BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32 XPO1interactor90.47215.167CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
33 XRCC6oncoprotein70.4674.667Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BIRC5parental proteinBIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
2 CDKN1BsuppressorCDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
3 CLIP3interactorAnk (PF00023, IPR002110, SM00248): Ankyrin repeat
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
4 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 HIST1H2BGoncoproteinHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
6 HIST2H3CinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
7 HIST3H3interactorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
8 KCNJ6interactorIRK (PF01007, IPR016449): Inward rectifier potassium channel
9 SKP2suppressorLRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
10 SPDYAparental proteinSpy1 (PF11357, IPR020984): Cell cycle regulatory protein

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