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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DB356740 is the fusion of parental proteins SLC33A1 (from a repository: Wed Dec 11 19:38:24 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins11 (21.15 %)
The number (and %) of the tumor suppressors6 (11.54 %)
Total number of binary PPIs (saturation %)80 (6.03 %)
The number (and %) of affected PPIs51 (63.75 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI2.692
Assortativity coefficient-0.3447
The network average Clustering coefficient0.437
The number (and %) of a zero Clustering coefficients25 (48.08 %)
The number (and %) of a zero Betweenness Centrality43 (82.69 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SLC33A1 All fusions
: DB356740;
Proteins found in more fusions NF2 (see 1 fusions); IMMT (see 4 fusions); CKAP4 (see 5 fusions); EEF1D (see 3 fusions); HSP90AB1 (see 1 fusions); EEF1G (see 1 fusions); ATP5A1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB356740chimera510.0152496.333Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
2 ARHGEF7interactor21.0000Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
3 ATP2A2interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 ATP5A1protein found in more fusions60.4006.000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
5 ATP5Einteractor21.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
6 ATP5Ointeractor21.0000OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
7 CANXinteractor30.6671.000Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
8 CEPT1interactor100CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase
9 CKAP2interactor100Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
CKAP2_C (PF15297, IPR029197): Cytoskeleton-associated protein 2 C-terminus
10 CKAP4protein found in more fusions50.5002.667DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
11 CLCN7interactor30.6670.667CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
12 CLIC1interactor100GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
13 DOCK6interactor100DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
14 EEF1Dprotein found in more fusions40.6671.000EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
15 EEF1Gprotein found in more fusions31.0000EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
16 ELMO3interactor100ELMO_CED12 (PF04727, IPR006816): ELMO/CED-12 family
DnaB_bind (PF10410, IPR019475): DnaB-helicase binding domain of primase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
17 EVC2interactor21.0000HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
18 GIT1interactor31.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
19 HAX1interactor21.0000Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
20 HSP90AB1oncoprotein40.6671.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
21 HSP90B1suppressor21.0000CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
22 IMMTprotein found in more fusions31.0000Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
23 KIAA0368interactor21.0000HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
24 MAT2Asuppressor200S-AdoMet_synt_C (PF02773, IPR022630): S-adenosylmethionine synthetase, C-terminal domain
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
25 MCATinteractor21.0000Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
26 METTL8interactor100Methyltransf_28 (PF02636, IPR003788): Putative S-adenosyl-L-methionine-dependent methyltransferase
Methyltransf_25 (PF13649): Methyltransferase domain
27 MKI67interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
K167R (PF08065, IPR012568): K167R (NUC007) repeat
PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
AROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
28 MSL1interactor100Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
PEHE (PF15275, IPR029332): PEHE domain
MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
29 MST1Rsuppressor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
30 MYO1Einteractor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 NCLNinteractor21.0000Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
32 NF2suppressor200ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
33 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
34 PATJoncoprotein100L27_2 (PF09045, IPR015132): L27_2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
35 PDFinteractor100Pep_deformylase (PF01327, IPR023635): Polypeptide deformylase
36 PFN1suppressor21.0000Profilin (PF00235, IPR005455, SM00392): Profilin
37 PHGDHinteractor1002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
38 RAD50interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
YscO (PF07321, IPR009929): Type III secretion protein YscO
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2703 (PF10865, IPR021219): Domain of unknown function (DUF2703)
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
AAA_13 (PF13166, IPR026866): AAA domain
AAA_23 (PF13476): AAA domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
39 RAD51interactor31.0000Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
40 SEMA3Bsuppressor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
41 SLC27A2interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
42 SLC7A1interactor21.0000AA_permease_2 (PF13520, IPR002293): Amino acid permease
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
43 SNUPNinteractor100mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain
Snurportin1 (PF11538, IPR024721): Snurportin1
44 TAGLN2interactor100Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
45 TAP1oncoprotein21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
46 TCEB2interactor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
47 TMEM17interactor40.5002.667Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
48 TMEM216interactor30.6670.667Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
49 TPM4oncoprotein100Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
50 USP24oncoprotein100Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
GRP (PF07172, IPR010800): Glycine rich protein family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
51 ZNF598interactor100Arc_trans_TRASH (PF08394, IPR013603): Archaeal TRASH domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
52 ZW10interactor21.0000Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 C19orf43interactorNA
2 RAB14oncoproteinRas (PF00071, IPR001806, SM00173): Ras family
3 SLC33A1parental proteinAcatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
4 TCTN2interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
5 TCTN3interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
6 TMEM57interactorMacoilin (PF09726, IPR019130): Transmembrane protein

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