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Visualization interactions

Powered by Cytoscape Web for: DB313344 is the fusion of parental proteins TNKS2, S100A11 (from a repository: Mon Sep 24 21:47:15 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins8 (42.11 %)
The number (and %) of the tumor suppressors3 (15.79 %)
Total number of binary PPIs (saturation %)46 (26.90 %)
The number (and %) of affected PPIs18 (39.13 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.895
Assortativity coefficient-0.4244
The network average Clustering coefficient0.473
The number (and %) of a zero Clustering coefficients5 (26.32 %)
The number (and %) of a zero Betweenness Centrality7 (36.84 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions
PPI for parental proteins: S100A11,TNKS2 All fusions
: DB313344;
Proteins found in more fusions MCM2 (see 1 fusions); PLP2 (see 2 fusions); NCL (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam, InterPro, SMART): description
1 DB313344chimera180.124237.233S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
2 AGO2interactor30.6671.000ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3 ANXA1suppressor70.4006.833Annexin (PF00191, IPR018502, SM00335): Annexin
4 ATF2oncoprotein40.6670.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
5 ATP6V1B1interactor100ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
6 CUL5suppressor70.42910.400Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 HDLBPoncoprotein100BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
8 IGBP1interactor30.6671.000TAP42 (PF04177, IPR007304): TAP42-like family
9 MCM2oncoprotein60.5004.067AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
10 MOV10interactor30.6670.400AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
11 NCLprotein found in more fusions50.8330.500DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
12 NPM1suppressor70.5334.833Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
13 NXF1interactor50.8330.400NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
14 PLP2protein found in more fusions200MARVEL (PF01284, IPR008253): Membrane-associating domain
15 S100Boncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
16 SHMT2interactor30.6670.667SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
17 STAMinteractor21.0000GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18 TACC1oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
19 TERF1interactor31.0000TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AP2M1interactorAdap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
2 BABAM1interactorVWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
3 EPN3interactorENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
4 FTCDinteractorFTCD (PF02971, IPR013802): Formiminotransferase domain
FTCD_C (PF04961, IPR007044): Formiminotransferase-cyclodeaminase
FTCD_N (PF07837, IPR012886): Formiminotransferase domain, N-terminal subdomain
5 GRB14interactorBPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
6 LNPEPoncoproteinPeptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
Dynactin (PF12455, IPR022157): Dynein associated protein
7 MAPK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
8 PTENsuppressorDSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
9 RNF166interactorzf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
10 S100A11parental proteinS_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 SH3BP2oncoproteinPH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
12 SLC35A5interactorNuc_sug_transp (PF04142, IPR007271): Nucleotide-sugar transporter
13 TNKS1BP1interactorTankyrase_bdg_C (PF15327, IPR032764): Tankyrase binding protein C terminal domain
14 TNKS2parental proteinAnk (PF00023, IPR002110, SM00248): Ankyrin repeat
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
15 UBE2FinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
16 ZNF512BinteractorYTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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