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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DB312529 is the fusion of parental proteins N4BP2L2, MBP (from a repository: Sat Mar 4 10:11:34 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins24 (48.00 %)
The number (and %) of the tumor suppressors6 (12.00 %)
Total number of binary PPIs (saturation %)126 (10.29 %)
The number (and %) of affected PPIs49 (38.89 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI3.720
Assortativity coefficient-0.3276
The network average Clustering coefficient0.478
The number (and %) of a zero Clustering coefficients16 (32.00 %)
The number (and %) of a zero Betweenness Centrality28 (56.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MBP,N4BP2L2 All fusions
: DB312529;
Proteins found in more fusions ULK1 (see 2 fusions); ATN1 (see 1 fusions); PRMT5 (see 2 fusions); STK3 (see 1 fusions); MAPK1 (see 1 fusions); MAPK14 (see 1 fusions); LIMK1 (see 1 fusions); ATXN1 (see 3 fusions); MAP3K5 (see 1 fusions); PRKDC (see 3 fusions); SQSTM1 (see 5 fusions); LRRK2 (see 1 fusions); TLK1 (see 1 fusions); HIPK2 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB312529chimera490.0372156.167Myelin_MBP (PF01669, IPR000548): Myelin basic protein
2 ABL1oncoprotein60.4005.333Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 APTXinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4 ATN1protein found in more fusions200Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
5 ATXN1protein found in more fusions200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 CDK1oncoprotein60.4005.167Pkinase (PF00069, IPR000719): Protein kinase domain
7 CDK5oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
8 CDK7oncoprotein50.5002.000Pkinase (PF00069, IPR000719): Protein kinase domain
9 CDK8interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
10 CDK9protein found in more fusions40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
11 CTDSP1interactor100NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
12 DDX58suppressor60.5005.000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
AAA_22 (PF13401, IPR003593): AAA domain
Syntaxin_2 (PF14523): Syntaxin-like protein
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
13 HIPK2suppressor31.0000Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
14 HLA-DRAinteractor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
15 IKBKEinteractor41.0000IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
16 IRAK4interactor100Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
17 LIMK1oncoprotein40.6671.000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
18 LIMK2interactor21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
19 LMO2oncoprotein200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
20 LRRK2oncoprotein50.5002.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
21 MAP3K3oncoprotein31.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
22 MAP3K5oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
23 MAPK1oncoprotein80.42910.667Pkinase (PF00069, IPR000719): Protein kinase domain
24 MAPK11interactor40.6672.000HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Pkinase (PF00069, IPR000719): Protein kinase domain
25 MAPK12oncoprotein40.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
26 MAPK13oncoprotein30.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
27 MAPK14oncoprotein90.39315.667Pkinase (PF00069, IPR000719): Protein kinase domain
28 MAPK3oncoprotein50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
29 MELKinteractor200KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
30 MUS81suppressor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
31 MYH6interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
32 PKN1interactor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
33 PLP1interactor100Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
34 PPP2R5Csuppressor21.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
35 PRKCAinteractor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
36 PRKCBsuppressor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
37 PRKCIinteractor40.6671.500PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
38 PRKCZinteractor60.5004.333PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
39 PRKDCprotein found in more fusions40.6670.667FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
40 PRMT5protein found in more fusions31.0000PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
41 RPS6KA5interactor40.8330.667Choline_kinase (PF01633): Choline/ethanolamine kinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
42 RPS6KA6suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
43 SQSTM1oncoprotein120.21841.333PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
44 STK3protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
45 STK39interactor31.0000BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein)
FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
46 TBK1interactor50.6672.000DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
47 TLK1protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
48 TRPM7interactor200Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Ion_trans (PF00520, IPR005821): Ion transport protein
DUF3893 (PF13032, IPR024996): Domain of unknown function (DUF3893)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
49 TSSK6interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
50 ULK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CGRRF1interactorzf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 HOXA1interactorHomeobox (PF00046, IPR001356, SM00389): Homeobox domain
3 LGR4interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
4 MBPparental proteinMyelin_MBP (PF01669, IPR000548): Myelin basic protein
5 N4BP2L2parental proteinDUF2897 (PF11446, IPR021550): Protein of unknown function (DUF2897)
AAA_33 (PF13671): AAA domain
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
6 NAA38interactorLSM (PF01423, IPR001163): LSM domain
7 PPIAinteractorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
8 PPIHinteractorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
9 PRG2interactorLectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
10 PRMT6interactorMethyltransf_25 (PF13649): Methyltransferase domain
11 PRPF4interactorPRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
12 TMPRSS5interactorTrypsin (PF00089, IPR001254, SM00020): Trypsin
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
13 WNT4interactorMEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family

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