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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: DB219427 is the fusion of parental proteins DNAJC10, SNCAIP (from a repository: Thu Dec 22 05:05:27 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins15 (42.86 %)
The number (and %) of the tumor suppressors9 (25.71 %)
Total number of binary PPIs (saturation %)166 (27.90 %)
The number (and %) of affected PPIs34 (20.48 %)
The number of possible different fusions15
PPI diameter2
PPI radius1
The average degree of PPI8.286
Assortativity coefficient-0.3720
The network average Clustering coefficient0.639
The number (and %) of a zero Clustering coefficients6 (17.14 %)
The number (and %) of a zero Betweenness Centrality13 (37.14 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: DNAJC10,SNCAIP All fusions
: DB219427;
Proteins found in more fusions CSNK2A1 (see 1 fusions); COPS5 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); CUL4A (see 4 fusions); SFTPC (see 1 fusions); SMURF2 (see 1 fusions); VCP (see 4 fusions); PINK1 (see 3 fusions); TCF3 (see 4 fusions); GAN (see 1 fusions); MCM2 (see 1 fusions); YWHAH (see 2 fusions); GSK3B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB219427chimera340.198711.960Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
2 CAND1interactor140.8462.730Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
3 CDC42oncoprotein50.6671.667Ras (PF00071, IPR001806, SM00173): Ras family
4 COPS5protein found in more fusions170.68324.194JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
5 CSNK2A1oncoprotein60.6003.222Pkinase (PF00069, IPR000719): Protein kinase domain
6 CUL1suppressor140.7955.064Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 CUL2suppressor120.8941.430Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
8 CUL3protein found in more fusions170.70017.761Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
9 CUL4Aprotein found in more fusions140.70513.570Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 CUL4Boncoprotein130.8462.884Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
11 CUL5suppressor140.8682.361Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 DCUN1D1interactor120.9240.912Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
13 EDEM1interactor100Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
14 ESRRBsuppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 FOXRED2interactor100Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
16 FUSsuppressor160.7509.393Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 GANprotein found in more fusions41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
18 GSK3Bsuppressor40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
19 HNRNPA1interactor180.61029.993RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
20 IFI16suppressor30.6670.667HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
21 MAGEA11interactor31.0000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
22 MCM2oncoprotein120.56412.748AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
23 NEDD8interactor120.9270.730ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
24 NTRK1oncoprotein160.61924.411I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
25 PARK2suppressor90.50012.067IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 PCSK9interactor100Peptidase_S8 (PF00082, IPR000209): Subtilase family
Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
27 PINK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
28 SFTPCprotein found in more fusions31.0000BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
29 SMURF2protein found in more fusions31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30 TCF3suppressor200CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
31 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
32 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
33 TXNL1interactor21.0000PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
34 VCPprotein found in more fusions150.61519.948AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
35 YWHAHprotein found in more fusions70.7331.28914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARIH1interactorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
2 C11orf58interactorDUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
3 DNAJC10parental proteinDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
4 GET4interactorDUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
5 HERPUD1oncoproteinNeisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
6 HSPA4interactorHerpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
7 HSPA4LinteractorHSP70 (PF00012, IPR013126): Hsp70 protein
8 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
9 KALRNoncoproteinfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spectrin (PF00435, IPR002017): Spectrin repeat
UPF0302 (PF08864, IPR014963): UPF0302 domain
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
10 NUB1interactorGlyphos_transf (PF04464, IPR007554): CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
TPR_12 (PF13424): Tetratricopeptide repeat
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
11 NUDT21interactorNUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
12 PIN1suppressorRotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
13 PPHLN1interactorLge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
14 PPP1CAsuppressorMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
15 PPP1CConcoproteinMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PSMC4interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
17 PTNoncoproteinPTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
18 RNF19AinteractorIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
19 SH2D3CinteractorRasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
20 SIAH1suppressorSina (PF03145, IPR018121): Seven in absentia protein family
21 SIAH2oncoproteinSina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
22 SNCAinteractorSynuclein (PF01387, IPR001058): Synuclein
23 SNCAIPparental proteinAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain

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