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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DB146434 is the fusion of parental proteins PGGHG, RBCK1 (from a repository: Sun Feb 4 10:08:56 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins15 (48.39 %)
The number (and %) of the tumor suppressors3 (9.68 %)
Total number of binary PPIs (saturation %)114 (24.52 %)
The number (and %) of affected PPIs30 (26.32 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI6.000
Assortativity coefficient-0.3936
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients9 (29.03 %)
The number (and %) of a zero Betweenness Centrality13 (41.94 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RBCK1,PGGHG All fusions
: DB146434;
Proteins found in more fusions RIPK1 (see 1 fusions); TAB2 (see 1 fusions); HSP90AA1 (see 2 fusions); MAP3K1 (see 1 fusions); TRAF6 (see 1 fusions); MAP3K7 (see 7 fusions); MALT1 (see 1 fusions); TNF (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB146434chimera300.145620.105Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
2 ARNT2interactor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
3 BIRC3oncoprotein90.7504.036BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
4 DDX58suppressor60.5003.833DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
AAA_22 (PF13401, IPR003593): AAA domain
Syntaxin_2 (PF14523): Syntaxin-like protein
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
5 HSP90AA1oncoprotein100.47215.536HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
6 IKBKGinteractor170.45841.271CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
7 MALT1oncoprotein70.8670.536Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
8 MAP3K1oncoprotein200zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
9 MAP3K7oncoprotein110.6446.517Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
10 NAA10oncoprotein100Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
11 NOD2interactor90.7502.533CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
12 OTUD6Ainteractor100OTU (PF02338, IPR003323): OTU-like cysteine protease
FlxA (PF14282, IPR025577): FlxA-like protein
13 PAXIP1interactor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
14 PRKCAinteractor40.6670.500C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
15 PRKCBsuppressor50.8330.500C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
16 RIPK1protein found in more fusions110.6676.088Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
17 RNF181interactor200AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
18 SHARPINinteractor70.8001.019DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
19 TAB2oncoprotein100.6944.483CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
20 TAB3oncoprotein61.0000CUE (PF02845, IPR003892, SM00546): CUE domain
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
21 TNFoncoprotein80.7622.036TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
22 TNFAIP3suppressor120.6009.369OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
23 TRAF1oncoprotein90.6437.383HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
24 TRAF6protein found in more fusions120.56413.921SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
25 TRIM21interactor31.0000DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
26 TRIM65interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
27 TRIML1interactor100MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
28 TSSK3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
29 USP15oncoprotein60.5004.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
30 USP32oncoprotein100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
31 USP49interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
2 BACH1interactorBTB (PF00651, IPR013069, SM00225): BTB/POZ domain
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
3 ESR1suppressorOest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
4 FKBPLinteractorBTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
5 IREB2interactorAconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
6 LDLRAD4interactorLdl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
7 LTBRoncoproteinEphrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
8 MKRN2interactorRecR (PF02132, IPR023628): RecR protein
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
9 NDUFAF3interactorDUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
10 NEDD4suppressorRota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
11 NR1I2suppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
12 NR2C2suppressorFlagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
13 OTUB2interactorPeptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
14 OTULINinteractorPeptidase_C101 (PF16218, IPR023235): Peptidase family C101
15 PAN2interactorRNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
16 PARK2suppressorIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
17 PCGF2suppressorzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
18 PGGHGparental proteinGlyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
DUF2152 (PF10222, IPR018795): Uncharacterized conserved protein (DUF2152)
19 PMLsuppressorzf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
20 PSMD4interactorUIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
21 RBCK1parental proteinGAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
22 RNF31interactorAuto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
PUB (PF09409, IPR018997): PUB domain
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
23 SYCE1interactorCENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
24 TRIM25interactorFes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
25 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 UBE2D1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
27 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 UBE2D3interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
29 UBE2D4interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30 UBE2G1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 UBE2KinteractorUBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
32 UBE2L3interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
33 UBE2L6interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2NinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UBE2SinteractorALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 UBE2UinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
37 UCHL5oncoproteinPeptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
38 UHRF2suppressorPHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
39 USP2interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
40 USP21interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
41 USP7oncoproteinMATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

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