Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: DB108304 is the fusion of parental proteins GAPDHS, NOP16 (from a repository: Mon May 22 19:17:26 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins5 (21.74 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)42 (16.60 %)
The number (and %) of affected PPIs22 (52.38 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.957
Assortativity coefficient-0.5814
The network average Clustering coefficient0.349
The number (and %) of a zero Clustering coefficients12 (52.17 %)
The number (and %) of a zero Betweenness Centrality17 (73.91 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NOP16,GAPDHS All fusions
: DB108304;
Proteins found in more fusions SH3BP4 (see 2 fusions); APP (see 4 fusions); COPS5 (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB108304chimera220.052414.833Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
2 APPprotein found in more fusions80.33313.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 CAND1interactor50.6671.333Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
4 COPS5protein found in more fusions70.4677.500JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
5 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
6 GAPDHoncoprotein50.8330.500Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
7 GDE1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
8 GPX8interactor100GSHPx (PF00255, IPR000889): Glutathione peroxidase
SCO1-SenC (PF02630, IPR003782): SCO1/SenC
9 INSL3interactor100Insulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
10 KLRF1interactor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
Furin-like_2 (PF15913, IPR006212): Furin-like repeat, cysteine-rich
11 MAFFinteractor200bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
12 MEIOBinteractor100Pox_H7 (PF04787, IPR006872): Late protein H7
Spt4 (PF06093, IPR022800): Spt4/RpoE2 zinc finger
DZR (PF12773, IPR025874): Double zinc ribbon
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
13 NTHL1interactor100HhH-GPD (PF00730, IPR003265): HhH-GPD superfamily base excision DNA repair protein
14 NUSAP1interactor21.0000GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
15 PSG11interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
16 SH3BP4protein found in more fusions200SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
17 SLC45A2interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
MFS_2 (PF13347): MFS/sugar transport protein
18 SLC5A2interactor100SSF (PF00474, IPR001734): Sodium:solute symporter family
19 SPZ1interactor21.0000GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PCRF (PF03462, IPR005139, SM00937): PCRF domain
DUF3150 (PF11348, IPR021496): Protein of unknown function (DUF3150)
DUF4410 (PF14366, IPR025522): Domain of unknown function (DUF4410)
20 TARDBPinteractor40.6670.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 THAP1interactor31.0000THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
22 TRA2Ainteractor21.0000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
23 TRIP6interactor21.0000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADARB1suppressordsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
2 ADARB2oncoproteindsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
3 EPB41L1interactor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
4 GAPDHSparental proteinGp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
5 HP1BP3interactorRXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
6 IFI16suppressorHIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
7 MYBBP1AsuppressorDNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
8 NAP1L1interactorNAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
9 NCSTNinteractorNicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
10 NOLC1interactorDTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
11 NOP16parental proteinNop16 (PF09420, IPR019002): Ribosome biogenesis protein Nop16
12 NOP56interactorCytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
13 NPM1suppressorNucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
14 PRKRAinteractordsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
15 PRR11interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 RBM4BinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
17 SAMD7interactorSAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
18 SNU13interactorRibosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
19 SRPK1interactorFYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
20 SRPK2oncoproteinDUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
21 ZC3H3interactorzf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family

B a c k    t o    T o p ⇑