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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DB080871 is the fusion of parental proteins BMS1, OSCP1 (from a repository: Wed Mar 29 06:19:11 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins4 (25.00 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)36 (30.00 %)
The number (and %) of affected PPIs15 (41.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient-0.2342
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients3 (18.75 %)
The number (and %) of a zero Betweenness Centrality6 (37.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: BMS1,OSCP1 All fusions
: DB080871;
Proteins found in more fusions GRK5 (see 4 fusions); CSNK2A1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB080871chimera150.162146.333AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
E7 (PF00527, IPR000148): E7 protein, Early protein
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
NOA36 (PF06524, IPR010531): NOA36 protein
2 CSNK2A1oncoprotein50.6671.500Pkinase (PF00069, IPR000719): Protein kinase domain
3 FOXM1oncoprotein100EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
4 GRK5protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
5 HDGFinteractor30.6671.000PWWP (PF00855, IPR000313, SM00293): PWWP domain
6 HIST1H3Einteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
7 IFI16suppressor40.6671.333HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
8 MEX3Cinteractor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 NIFKinteractor50.6003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
10 NXF1interactor80.33313.500NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
11 RNF2interactor50.5002.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
12 RPSAinteractor30.6670.500Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
13 RRS1interactor40.8330.500GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
14 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
15 SIRT7interactor60.4676.333DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
16 USP42interactor100TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BMS1parental proteinAARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
E7 (PF00527, IPR000148): E7 protein, Early protein
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
NOA36 (PF06524, IPR010531): NOA36 protein
2 OSCP1parental proteinOscp1 (PF10188, IPR019332): Organic solute transport protein 1
3 WDR54interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PQQ_3 (PF13570): PQQ-like domain
4 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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