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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DB012755 is the fusion of parental proteins PKN1, ARL6IP6 (from a repository: Tue Mar 21 13:49:24 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)62
The number (and %) of the onco-proteins21 (33.87 %)
The number (and %) of the tumor suppressors6 (9.68 %)
Total number of binary PPIs (saturation %)189 (9.99 %)
The number (and %) of affected PPIs61 (32.28 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.226
Assortativity coefficient-0.2917
The network average Clustering coefficient0.559
The number (and %) of a zero Clustering coefficients9 (14.52 %)
The number (and %) of a zero Betweenness Centrality22 (35.48 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PKN1,ARL6IP6 All fusions
: DB012755;
Proteins found in more fusions ACTN1 (see 3 fusions); HDAC5 (see 1 fusions); APP (see 4 fusions); KMT2A (see 16 fusions); MAPK9 (see 3 fusions); HSP90AA1 (see 2 fusions); CEP57L1 (see 1 fusions); MYC (see 1 fusions); HOMER3 (see 1 fusions); MAPT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DB012755chimera610.0553130.167HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
2 ACTN1protein found in more fusions70.6672.833CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 AKAP9oncoprotein100ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Hema_stalk (PF08720, IPR014831): Influenza C hemagglutinin stalk
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Macoilin (PF09726, IPR019130): Transmembrane protein
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
4 APPprotein found in more fusions150.23164.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ASH2Linteractor51.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
6 C1orf186interactor21.0000DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
7 CASP3interactor60.5004.667Peptidase_C14 (PF00656, IPR011600): Caspase domain
8 CCDC85Binteractor100CCDC85 (PF10226, IPR019359): CCDC85 family
9 CCNT2interactor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
10 CD81interactor70.4677.067Tetraspannin (PF00335, IPR018499): Tetraspanin family
11 CDC25Concoprotein30.6671.000M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
12 CDR2interactor40.6671.000DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
13 CEP57L1protein found in more fusions60.4006.000Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
XhlA (PF10779, IPR019715): Haemolysin XhlA
YqzE (PF14038, IPR025622): YqzE-like protein
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
14 DUSP3interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
15 GOLGA2interactor30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
16 HDAC5protein found in more fusions70.5333.800Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
17 HDAC6oncoprotein70.8001.667Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
18 HIST1H1Ainteractor40.5002.400Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
19 HIST2H3Cinteractor40.6671.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
20 HOMER3protein found in more fusions31.0000COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
21 HSP90AA1oncoprotein130.42427.867HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
22 KMT2Aoncoprotein60.8001.333AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
23 KRT15interactor30.6671.000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 KRT31interactor30.6671.000Filament (PF00038, IPR001664): Intermediate filament protein
25 MAGEA10interactor100MAGE (PF01454, IPR002190): MAGE family
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
26 MAP2K3interactor50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
27 MAP2K6interactor30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
28 MAPK11interactor50.5005.000HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Pkinase (PF00069, IPR000719): Protein kinase domain
29 MAPK12oncoprotein30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
30 MAPK9suppressor60.4005.667Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
31 MAPTprotein found in more fusions60.6002.900Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
32 MARCKSsuppressor31.0000MARCKS (PF02063, IPR002101): MARCKS family
33 MBPinteractor30.6671.000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
34 MID1oncoprotein41.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
35 MYConcoprotein100.47217.067HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
36 NEFHinteractor21.0000DUF1388 (PF07142, IPR010790): Repeat of unknown function (DUF1388)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Filament (PF00038, IPR001664): Intermediate filament protein
37 NEFLinteractor50.5005.000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
NOA36 (PF06524, IPR010531): NOA36 protein
BORG_CEP (PF14957, IPR029273): Cdc42 effector
38 NEUROD2interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SipA (PF09052, IPR015138): Salmonella invasion protein A
Neuro_bHLH (PF12533, IPR022575): Neuronal helix-loop-helix transcription factor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
39 NTRK1oncoprotein140.32143.933I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
40 PA2G4interactor60.4006.333Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
41 PDK1interactor31.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
42 PDPK1interactor50.6671.067Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
43 PLAURoncoprotein21.0000Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
44 PLD1suppressor30.6671.000PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
45 PPM1Asuppressor21.0000PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
46 PPM1Ginteractor40.5003.000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
47 RBBP5oncoprotein70.6004.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
48 RHOAsuppressor30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
49 SNX3interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
50 SPRR2Dinteractor100SPRR2 (PF14820, IPR029142): Small proline-rich 2
51 SSX2IPinteractor70.4008.067ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
52 TBXA2Rinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
53 TNFRSF1Boncoprotein41.0000TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
54 TOM1L1interactor100GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
55 TRAF1oncoprotein50.6671.667HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
56 TRAF2interactor60.5004.667MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
57 TUBA1Aoncoprotein130.37238.300Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
58 TUBBinteractor100.53312.467Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
59 VIMsuppressor70.5335.667Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
60 WBSCR22interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
WBS_methylT (PF12589, IPR022238): Methyltransferase involved in Williams-Beuren syndrome
61 WDR5interactor100.28926.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
62 ZNF282interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3669 (PF12417, IPR022137): Zinc finger protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARL6interactorArf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
2 ARL6IP6parental proteinDUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
3 BLVRBinteractorNAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
4 CBFBsuppressorCBF_beta (PF02312, IPR003417): Core binding factor beta subunit
5 GSTM1oncoproteinGST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
6 NAA50interactorAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
7 NME2P1interactorNA
8 PKN1parental proteinC2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
9 PMVKinteractorP-mevalo_kinase (PF04275, IPR005919): Phosphomevalonate kinase
10 PNPOinteractorPyridox_oxidase (PF01243, IPR011576): Pyridoxamine 5'-phosphate oxidase
PNPOx_C (PF10590, IPR019576): Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
11 PYGBinteractorPhosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
12 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
13 YKT6interactorSynaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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