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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA824273 is the fusion of parental proteins RFWD2, PRKAB2 (from a repository: Sat May 27 00:33:58 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)127
The number (and %) of the onco-proteins39 (30.71 %)
The number (and %) of the tumor suppressors18 (14.17 %)
Total number of binary PPIs (saturation %)688 (8.60 %)
The number (and %) of affected PPIs126 (18.31 %)
The number of possible different fusions19
PPI diameter2
PPI radius1
The average degree of PPI10.205
Assortativity coefficient-0.3118
The network average Clustering coefficient0.612
The number (and %) of a zero Clustering coefficients11 (8.66 %)
The number (and %) of a zero Betweenness Centrality35 (27.56 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RFWD2,PRKAB2 All fusions
: DA824273;
Proteins found in more fusions PTPN11 (see 1 fusions); CUL4A (see 4 fusions); MAGED1 (see 1 fusions); FOXO1 (see 1 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); RBPMS (see 2 fusions); MDM4 (see 2 fusions); PIAS2 (see 2 fusions); PSME3 (see 2 fusions); PRKDC (see 3 fusions); YWHAZ (see 1 fusions); RACK1 (see 3 fusions); FOS (see 4 fusions); COPS5 (see 1 fusions); DDB1 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA824273chimera1260.06611983.366IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
WD40_like (PF17005, IPR031544): WD40-like domain
2 ADAMTSL4interactor60.4674.900ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
3 AGLinteractor60.8670.230GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
4 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
5 BAIAP2L1interactor31.0000IMD (PF08397, IPR013606): IRSp53/MIM homology domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
SH3_9 (PF14604, IPR001452): Variant SH3 domain
6 BEND5interactor100LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
T4SS (PF07996, IPR014158): Type IV secretion system proteins
BEN (PF10523, IPR018379, SM01025): BEN domain
7 BLZF1interactor21.0000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
ZapB (PF06005, IPR009252): Cell division protein ZapB
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
8 BTBD2interactor90.8890.556BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
9 CALCOCO2interactor90.35715.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
10 CCDC33interactor80.32117.667C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
11 CCT2interactor130.8213.383Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT3interactor110.9450.300Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CCT4interactor130.8213.383Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CCT5interactor120.8482.690Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 CCT6Ainteractor120.8185.600Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16 CCT7interactor110.9450.300Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CCT8interactor140.7259.683Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CDKN1Bsuppressor140.52720.831CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
19 COPS2suppressor220.68820.316YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
20 COPS3interactor260.61538.463RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
21 COPS4interactor270.59850.244DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
22 COPS5protein found in more fusions440.354275.201JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
23 COPS6interactor320.473125.712DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
24 COPS7Ainteractor220.76610.439PCI (PF01399, IPR000717, SM00088): PCI domain
25 COPS7Binteractor200.75810.988PCI (PF01399, IPR000717, SM00088): PCI domain
26 COPS8interactor200.8424.441CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
27 CRTC2oncoprotein30.6670.333TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
28 CRXinteractor21.0000TF_Otx (PF03529, IPR013851): Otx1 transcription factor
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
29 CUL1suppressor290.40298.502Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
30 CUL2suppressor190.62619.031Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
31 CUL3protein found in more fusions410.297330.205Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
32 CUL4Aprotein found in more fusions290.55065.039Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
33 CUL4Boncoprotein260.59439.901Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
34 DCAF1protein found in more fusions170.8175.305DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
35 DCAF11interactor111.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
36 DDA1interactor200.72116.123DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
37 DDB1protein found in more fusions260.60053.511CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
38 DDB2suppressor240.56152.255WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
39 DET1interactor120.37928.605Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
40 DICER1suppressor50.6671.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
41 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
42 DSToncoprotein100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Phasin (PF05597, IPR008769): Poly(hydroxyalcanoate) granule associated protein (phasin)
Spectrin (PF00435, IPR002017): Spectrin repeat
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
XhlA (PF10779, IPR019715): Haemolysin XhlA
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
NYD-SP28 (PF14772): Sperm tail
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
43 ELAVL1oncoprotein260.250173.457RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
44 ERCC8oncoprotein160.8583.581WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
45 ETS1oncoprotein50.7001.152Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
46 ETS2suppressor60.6003.117Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
47 ETV1oncoprotein50.4002.683Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
48 ETV4oncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
49 ETV5oncoprotein40.5001.467Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
50 FANCIinteractor31.0000DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
51 FLNCinteractor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
52 FOSoncoprotein100.33316.019bZIP_1 (PF00170, IPR004827): bZIP transcription factor
53 FOSL2oncoprotein70.3817.567bZIP_1 (PF00170, IPR004827): bZIP transcription factor
54 FOXO1suppressor40.6670.286K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
55 GATA1oncoprotein21.0000GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
56 GATAD2Binteractor40.5002.000DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
57 GCN1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
58 GFPT1interactor50.6001.519SIS (PF01380, IPR001347): SIS domain
GATase_6 (PF13522): Glutamine amidotransferase domain
59 GOLGA2interactor50.4004.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
60 GRNoncoprotein40.5003.000Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
61 HSPA2interactor40.6671.500HSP70 (PF00012, IPR013126): Hsp70 protein
62 HSPA6interactor50.9000.111HSP70 (PF00012, IPR013126): Hsp70 protein
63 HSPA8oncoprotein160.53325.519HSP70 (PF00012, IPR013126): Hsp70 protein
64 JUNoncoprotein170.25864.075bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
65 JUNBoncoprotein30.6670.286bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
66 JUNDoncoprotein70.5714.405bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
67 KLF15interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
68 KLHL42interactor70.7624.333BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
69 KRTAP10-3interactor70.7331.733Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
70 KRTAP10-5interactor70.5335.333Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
71 KRTAP10-7interactor60.6003.400Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
72 KRTAP10-8interactor60.7001.333Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
73 LRR1interactor130.9101.325LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
74 LZTS2suppressor40.6671.667CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
75 MAGED1protein found in more fusions90.32117.667MAGE (PF01454, IPR002190): MAGE family
76 MAP3K15interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
MCM_N (PF14551, IPR027925): MCM N-terminal domain
77 MAP3K6oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3618 (PF12277, IPR022062): Protein of unknown function (DUF3618)
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
78 MAST3interactor21.0000DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
79 MDFIinteractor60.5004.000MDFI (PF15316, IPR026134): MyoD family inhibitor
80 MDM2oncoprotein190.35964.503Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
81 MDM4oncoprotein80.6673.952zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
82 MEOX2interactor90.27821.067Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
83 MVPoncoprotein160.16281.333Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
84 NEBLinteractor40.6671.500Bac_small_YrzI (PF09501, IPR012655): Probable sporulation protein (Bac_small_yrzI)
Annexin (PF00191, IPR018502, SM00335): Annexin
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
85 NET1oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
86 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
87 PIAS2protein found in more fusions60.5002.700SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
88 PRKAB1oncoprotein21.0000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
89 PRKDCprotein found in more fusions100.6393.446FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
90 PSMD11interactor50.6001.954DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
91 PSME3protein found in more fusions70.6673.000PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
92 PTPN1suppressor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
93 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
94 RACK1suppressor110.5569.527WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
95 RB1CC1suppressor40.6671.000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
96 RBPMSprotein found in more fusions70.4007.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
97 RBX1oncoprotein260.56746.775zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
98 RCHY1suppressor80.4298.486C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
99 REG1Ainteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
100 RELoncoprotein21.0000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
101 RHEBL1interactor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
102 RIMBP3interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
103 SFNsuppressor90.5007.24414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
104 SH3PXD2Ainteractor31.0000DUF1604 (PF07713, IPR011666): Protein of unknown function (DUF1604)
PX (PF00787, IPR001683, SM00312): PX domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
105 SIPA1oncoprotein100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
106 SKP1oncoprotein120.8182.097Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
107 STIM2interactor100DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
MAGSP (PF03082, IPR004315): Male accessory gland secretory protein
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
108 STK40interactor100.26729.619Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
109 STX11interactor60.4004.667KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
110 STX19interactor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
111 TADA2Ainteractor50.7001.417SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
112 TCEB2interactor100.8891.638ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
113 TCF4suppressor40.6671.333CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
114 TCP1interactor120.8941.272Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
115 TP53suppressor450.168607.587DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
116 TP53BP2suppressor40.8330.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
117 TRAF2interactor160.24870.852MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
118 TRIB1interactor50.6002.286Pkinase (PF00069, IPR000719): Protein kinase domain
119 TRIB2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
120 TRIB3interactor40.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
121 TRIM10interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
122 UBXN11interactor21.0000DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
123 WDR5interactor80.7143.137WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
124 YWHABinteractor90.41714.72214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
125 YWHAZprotein found in more fusions140.41027.34814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
126 ZBTB32interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
127 ZNF397interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BANPsuppressorDUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
2 CASP6interactorPeptidase_C14 (PF00656, IPR011600): Caspase domain
3 CCDC36interactorDUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
4 CDX4interactorCaudal_act (PF04731, IPR006820): Caudal like protein activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
5 CREB3L1suppressorbZIP_1 (PF00170, IPR004827): bZIP transcription factor
ELP6 (PF09807, IPR018627): Elongation complex protein 6
6 CSNK2BinteractorCK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
7 DAOinteractorDAO (PF01266, IPR006076): FAD dependent oxidoreductase
8 DCLRE1CinteractorDRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase
DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290)
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
9 DDIT4LinteractorRTP801_C (PF07809, IPR012918): RTP801 C-terminal region
10 EPM2AinteractorCBM_20 (PF00686, IPR002044): Starch binding domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
11 FAM208BinteractorDUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
12 FDX1interactorFer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
13 GET4interactorDUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
14 GYG1interactorGlyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
15 GYS1interactorGlycogen_syn (PF05693, IPR008631): Glycogen synthase
16 IKZF1suppressorDesulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
17 IKZF3suppressorC1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
18 KCTD5interactorBTB_2 (PF02214, IPR003131): BTB/POZ domain
19 KRT40interactorFilament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
20 KRTAP10-9interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
21 KRTAP4-12interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
22 KRTAP4-2interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
23 KRTAP5-9interactorEry_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
24 KRTAP9-2interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
25 KRTAP9-4interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
26 MAP3K5oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
27 MCL1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
28 PRDM14interactorDesulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
29 PRKAA1suppressorPkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
30 PRKAA2suppressorPkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
31 PRKAB2parental proteinAMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
32 PRKAG1interactorCBS (PF00571, IPR000644, SM00116): CBS domain
33 PRKAG2interactorCBS (PF00571, IPR000644, SM00116): CBS domain
34 PRKAG3interactorCBS (PF00571, IPR000644, SM00116): CBS domain
35 PYGMinteractorPhosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
36 RFWD2parental proteinHerpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
37 SPRY2suppressorKAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
38 TRAK2interactorZapB (PF06005, IPR009252): Cell division protein ZapB
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Milton (PF12448, IPR022154): Kinesin associated protein
39 UBE2D1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
40 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
41 ULK1interactorPkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
42 YY1AP1interactorCtnDOT_TraJ (PF07863, IPR012424): Homologues of TraJ from Bacteroides conjugative transposon
JAKMIP_CC3 (PF16034, IPR031994): JAKMIP CC3 domain

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