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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA808828 is the fusion of parental proteins TMCC2 (from a repository: Sat Nov 12 09:32:36 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins4 (18.18 %)
The number (and %) of the tumor suppressors2 (9.09 %)
Total number of binary PPIs (saturation %)56 (24.24 %)
The number (and %) of affected PPIs21 (37.50 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient0.0057
The network average Clustering coefficient0.650
The number (and %) of a zero Clustering coefficients2 (9.09 %)
The number (and %) of a zero Betweenness Centrality10 (45.45 %)


List of the fusions

PPI for parental proteins: TMCC2 All fusions
: DA808828;
Proteins found in more fusions APP (see 4 fusions); KAT5 (see 3 fusions); AES (see 3 fusions); AMOTL2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 DA808828chimera210.110324.167RAP1 (PF07218, IPR009864): Rhoptry-associated protein 1 (RAP-1)
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
2 AESprotein found in more fusions80.33312.667TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 AMOTL2protein found in more fusions31.0000HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
4 APPprotein found in more fusions90.28619.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 CCDC33interactor60.4007.667C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
6 CDR2interactor40.6671.000DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
7 CFAP206interactor31.0000THP2 (PF09432, IPR018557): Tho complex subunit THP2
DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
8 DIP2Ainteractor30.6670.500AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
9 DPY30interactor200Dpy-30 (PF05186, IPR007858): Dpy-30 motif
10 FAM161Ainteractor40.6671.000YajC (PF02699, IPR003849): Preprotein translocase subunit
UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
11 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
12 FBF1interactor40.6671.333DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
13 HGSinteractor40.6671.167FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
14 HSPD1suppressor21.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 IQUBinteractor200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3664 (PF12406, IPR022131): Surface protein
Stc1 (PF12898, IPR024630): Stc1 domain
DUF4041 (PF13250, IPR025280): Domain of unknown function (DUF4041)
16 KAT5suppressor31.0000MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
17 PRPF31interactor50.5003.000Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
18 RHOXF2interactor50.6671.167DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 ZNF250interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
20 ZNF417interactor21.0000A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
21 ZNF581interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
22 ZNF587interactor30.6671.000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EIF4E2interactorIF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
2 FAM74A4interactorNA
3 TMCC2parental proteinTmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
4 WT1-ASinteractorNA

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